Collects tissue samples to study head and neck disorders
Gathers tissue samples and data from people with head or neck conditions.
Plain-language title generated from the registry record
Registry title: Biospecimen Procurement for Head and Neck Disorders
Key facts
- Where
- Baltimore, Bethesda, and Washington D.C., United StatesSee the 9 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 3 and 120 years old?
Source: NCT03429036, who can take part
Where in United States
- Johns Hopkins Hospital BayviewBaltimore, United StatesTaking people
- Johns Hopkins Hospital Broadway BaltimoreBaltimore, United StatesTaking people
- Johns Hopkins Hospital GreenspringBaltimore, United StatesTaking people
- Johns Hopkins Otolaryngology ClinicBethesda, United StatesTaking people
- Johns Hopkins Suburban HospitalBethesda, United StatesTaking people
- National Institutes of Health Clinical CenterBethesda, United StatesTaking people
- George Washington University HospitalWashington D.C., United StatesTaking people
- Johns Hopkins Hospital Sibley Memorial HospitalWashington D.C., United StatesTaking people
- MedStar Georgetown University HospitalWashington D.C., United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Cancer Institute (NCI)
- Trial code
- NCT03429036
- Record updated
- 9 November 2026
- Original description
Background:Read full original descriptionShow less
Biospecimen Procurement for the Study of Head and Neck Disorders
Background:
Researchers want to learn more about head and neck disorders. Understanding these disorders could help them find better treatments. To do this, they are collecting tissue samples for research.
Objective:
To create a repository of tissue samples and data to better study conditions of the head and neck.
Eligibility:
People who had or will have tissue samples taken because of a head or neck disorder. They must be ages 3 and older and not pregnant to join Part 2.
Design:
Participants will be screened with a questionnaire, medical history, and physical exam.
Part 1. Participants will give permission for any of their tissue samples leftover from private care or other research protocols to be used.
If participants tissue did not contain normal tissue or if they have a condition that suggests a genetic issue, they will be invited to join Part 2.
Part 2: Participants will have additional samples collected. These could be:
* Blood: Blood is drawn through a needle in the arm. * Cheek swab or brushing: A cotton swab or small brush is rubbed inside the cheek. * Saliva: They rinse their mouth with water and spit into a tube or cup. * Skin biopsy: They are injected with a numbing drug. A biopsy tool removes a small piece of skin. * Mucosal biopsy: They are injected in the mouth with a numbing medication. A small piece of tissue from the inside of the cheek is removed.
Participants samples will be used for future research, including genetic testing.
Exclusion: Part 2: Additional exclusion criteria for the Part 2 prospective sample collection part of this protocol these criteria may be assessed prior to collection of the samples but will not affect overall eligibility for the trial (i.e., Part 1):; have active symptomatic major organ disorders that would increase the risk of biopsy for research, including but not limited to bleeding disorders, ischemic heart disease, a recent myocardial infarction, active congestive heart failure or severe pulmonary dysfunction; have specific medical condition, such as a bleeding tendency where additional biopsies or phlebotomy procedures may increase the participants' risk in participating. This will be determined at the discretion of the principal investigator; Individuals under the age of 18 are excluded from oral mucosal biopsies and skin biopsies; Part 1:; --Are unwilling to share waste specimens for research purposes.
INCLUSION CRITERIA:; Age 3 and older; Able to provide their own consent, or for minors, a parent or guardian is able to consent on their behalf; Diagnosis of a condition of the head and neck for which removal of biological specimens was indicated for clinical care or for research purposes under a separate Review Board (IRB) approved protocol; Ability of subject (or Legally Authorized Representative (LAR)) to understand and the willingness to sign a written informed consent document.