Tracking bone damage in rheumatoid arthritis using a high-resolution CT scanner
Studies bone damage in hand and wrist joints of adults with rheumatoid arthritis using scans.
Plain-language title generated from the registry record
Registry title: Progression of Bone Erosions in Rheumatoid Arthritis Assessed by HR-pQCT and Conventional X-ray
Key facts
- Where
- Aarhus, DenmarkSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with rheumatoid arthritis for 5 years or more. It also looks for adults with early signs of arthritis (pre-rheumatoid arthritis) and healthy adults without joint complaints.
- Age
- Over 18 years
- Sex
- All sexes
- Disease stage
- Rheumatoid arthritis for 5 years or more; or joint pain with a high anti-CCP result (pre-rheumatoid arthritis); or healthy people with no joint complaints.
- Earlier treatment
- People with rheumatoid arthritis are treated as outpatients. Anyone who has had a fracture or dislocation of the hand cannot join.
- Biomarker or test result
- Pre-rheumatoid arthritis group: anti-CCP 3 times the upper limit of the reference interval. Healthy group: anti-CCP must be negative.
Main reasons for not taking part
- Earlier fracture or dislocation of the hand
- Active or past cancer
- Underactive or overactive thyroid
- Low blood calcium
- Pregnancy
Read by machine on 9 November 2026.
Where in Denmark
- Department of Rheumatology, Aarhus University HospitalAarhus, DenmarkNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Aarhus University Hospital
- Trial code
- NCT03429426
- Record updated
- 13 January 2021
- Original description
Today, regular X-ray examination is not sufficiently sensitive for detecting progression of bone destruction in rheumatoid arthritis, but a new type of high-resolution CT scanner, the High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) can detect very early and minor joint injuries.Read full original descriptionShow less
An Observational Study of Bone Erosion Determination and Progression in Rheumatoid Arthritis Assessed by HR-pQCT and Conventional X-ray
Today, regular X-ray examination is not sufficiently sensitive for detecting progression of bone destruction in rheumatoid arthritis, but a new type of high-resolution CT scanner, the High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) can detect very early and minor joint injuries.
The purpose of this study is to use HR-pQCT techniques to look at the damage and disease activity progression in the hand and wrist joints of patients with rheumatoid arthritis.
Exclusion: Patients who have previously suffered trauma in the form of fracture or luxation of the hand are excluded; Patients who have previously suffered trauma in the form of fracture or luxation of the hand are excluded; Patients who have previously suffered trauma in the form of fracture or luxation of the hand are excluded; Evidence of active malignant disease; Evidence of malignant disease; Evidence of malignant disease; Earlier or present rheumatological disease or bone metabolic disease; Impaired renal function (eGFR <35ml/min); Impaired renal function (eGFR <35ml/min); Age over 18 years; Age over 18 years; Hypo- or hyperthyroidism; Hypocalcaemia; Pregnancy. Pre-rheumatoid arthritis patients Inclusion criteria; Anti-CCP 3 times the upper limit of the reference interval; Arthralgia; Ability and willingness to give written informed consent and to meet the requirements of the trial protocol; Pregnancy; Swelling of joints. Verified by clinical ultrasound; Hypo- or hyperthyroidism; Hypocalcaemia. Healthy subjects Inclusion criteria; No joint complaints; Ability and willingness to give written informed consent and to meet the requirements of the trial protocol; Hypo- or hyperthyroidism; Hypocalcaemia; Positive anti-CCP; Pregnancy.
Rheumatoid arthritis patients Inclusion criteria; Patients (> 18 years) with rheumatoid arthritis ≥5 years according to the ACR/EULAR (2010) classification criteria or American Rheumatism Association 1987 revised criteria for the patients who were diagnosed before 2010; Patients who are receiving treatment on an outpatient basis; Ability and willingness to give written informed consent and to meet the requirements of the trial protocol.