Progression of Bone Erosions in Rheumatoid Arthritis Assessed by HR-pQCT and Conventional X-ray
Key facts
- Where
- Aarhus, DenmarkSee the site
Where in Denmark
- Department of Rheumatology, Aarhus University HospitalAarhus, DenmarkNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Aarhus University Hospital
- Trial code
- NCT03429426
- Record updated
- 13 January 2021
- Original description
Today, regular X-ray examination is not sufficiently sensitive for detecting progression of bone destruction in rheumatoid arthritis, but a new type of high-resolution CT scanner, the High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) can detect very early and minor joint injuries.Read full original descriptionShow less
An Observational Study of Bone Erosion Determination and Progression in Rheumatoid Arthritis Assessed by HR-pQCT and Conventional X-ray
Today, regular X-ray examination is not sufficiently sensitive for detecting progression of bone destruction in rheumatoid arthritis, but a new type of high-resolution CT scanner, the High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) can detect very early and minor joint injuries.
The purpose of this study is to use HR-pQCT techniques to look at the damage and disease activity progression in the hand and wrist joints of patients with rheumatoid arthritis.
Exclusion: Patients who have previously suffered trauma in the form of fracture or luxation of the hand are excluded; Patients who have previously suffered trauma in the form of fracture or luxation of the hand are excluded; Patients who have previously suffered trauma in the form of fracture or luxation of the hand are excluded; Evidence of active malignant disease; Evidence of malignant disease; Evidence of malignant disease; Earlier or present rheumatological disease or bone metabolic disease; Impaired renal function (eGFR <35ml/min); Impaired renal function (eGFR <35ml/min); Age over 18 years; Age over 18 years; Hypo- or hyperthyroidism; Hypocalcaemia; Pregnancy. Pre-rheumatoid arthritis patients Inclusion criteria; Anti-CCP 3 times the upper limit of the reference interval; Arthralgia; Ability and willingness to give written informed consent and to meet the requirements of the trial protocol; Pregnancy; Swelling of joints. Verified by clinical ultrasound; Hypo- or hyperthyroidism; Hypocalcaemia. Healthy subjects Inclusion criteria; No joint complaints; Ability and willingness to give written informed consent and to meet the requirements of the trial protocol; Hypo- or hyperthyroidism; Hypocalcaemia; Positive anti-CCP; Pregnancy.
Rheumatoid arthritis patients Inclusion criteria; Patients (> 18 years) with rheumatoid arthritis ≥5 years according to the ACR/EULAR (2010) classification criteria or American Rheumatism Association 1987 revised criteria for the patients who were diagnosed before 2010; Patients who are receiving treatment on an outpatient basis; Ability and willingness to give written informed consent and to meet the requirements of the trial protocol.