Biobank Collecting Samples for Liver Bile Duct Disease Research
Collects blood and tissue samples from adults with bile duct liver diseases for future research.
Plain-language title generated from the registry record
Registry title: Biobank for Cholestatic Liver Diseases.
Key facts
- Where
- Rochester, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT03445585, who can take part
Where in United States
- Mayo ClinicRochester, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Mayo Clinic
- Trial code
- NCT03445585
- Record updated
- 17 February 2026
- Original description
This study is a biobank of specimens and clinical data for use in current and future research to better understand the cholestatic liver diseases primary biliary cirrhosis/cholangitis (PBC) and primary sclerosing cholangitis (PSC).Read full original descriptionShow less
A Resource of Blood and Other Biospecimens of Patients With Cholestatic Liver Disease and Unaffected Individuals
This study is a biobank of specimens and clinical data for use in current and future research to better understand the cholestatic liver diseases primary biliary cirrhosis/cholangitis (PBC) and primary sclerosing cholangitis (PSC).
Inclusion: PSC; Patients diagnosed with PSC and who are between the age of 18 and 85 at time of enrollment in the study; The diagnosis of PSC will be based on standard PSC criteria including clinical and biochemical evidence of chronic cholestasis of at least six months duration, positive cholangiographic findings, and compatible liver biopsies if available; Patients with PSC who have undergone orthotopic liver transplantation will be offered enrollment except for collection of bile - please see below under Exclusion Criteria; Women with PSC of childbearing potential and pregnant women will be offered enrollment because there is no risk to an unborn child in this investigation; PBC; Patients diagnosed with PBC and who are between the age of 18 and 85 at time of enrollment in the study; The diagnosis of PBC will be based on standard PBC criteria including clinical and biochemical evidence of chronic cholestasis of at least six month duration, positive anti-mitochondrial antibodies in serum and compatible liver biopsies, if available; Patients with PBC who have undergone orthotopic liver transplantation will be offered enrollment except for collection of bile - please see below under Exclusion Criteria; Women with PBC of childbearing potential and pregnant women will be offered enrollment because there is no risk to an unborn child in this investigation; Controls; Controls without history of PBC, PSC, or evidence of other chronic liver disease of either gender that participate in this study will be between the ages of 18 and 85; Liver Disease Controls; Patients without history of PBC or PSC but do have evidence of other chronic liver disease of either gender will be offered participation in this study if between the ages of 18 and 85.
Exclusion: PSC with orthotopic liver transplantation; PBC or PSC patients with known and overlapping other chronic liver diseases; History of Roux en Y; Patients unable to provide informed consent; Prisoners and institutionalized individuals.