Under construction – not a live service
Sign in
Taking people in United StatesNo phase

Registry of an AI tool used to search for cancer trials

Looks at an AI trial-search tool for people with advanced cancer.

Plain-language title generated from the registry record
Registry title: SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

Key facts

Where
Albuquerque, Ann Arbor, Atlanta, Aurora, Baltimore, Bethesda, Billings, Birmingham, Boise, Buffalo, Chapel Hill, Charlottesville, Chicago, Cincinnati, Columbus, Dallas, Denver, Duarte, Duluth, Fargo, Greenville, Hartford, Hattiesburg, Hempstead, Houston, Iowa City, Irvine, Jacksonville, Kansas City, La Jolla, Lansing, Little Rock, Littleton, Manhasset, Mayfield Heights, Memphis, Miami, Milwaukee, Mobile, Morgantown, Nashville, New Brunswick, New Orleans, New York, Newark, Norwalk, Omaha, Orange, Philadelphia, Portland, Providence, Salt Lake City, San Francisco, Savannah, Scarborough, Scottsdale, Seattle, Silver Spring, St Louis, Stanford, Staten Island, Tampa, Temple, Towson, Tulsa, Winston-Salem, and Worcester, United StatesSee the 67 sites

AI summary: who the study is looking for

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The registry is looking for people with solid or blood cancers whose tumour has a tested biomarker or gene change, and who are considering joining a clinical trial.

Sex
All sexes can join.
Disease stage
Solid and hematological (blood) cancers. The record also describes the registry as for advanced cancer.
Biomarker or test result
A cancer-related biomarker, gene variant, fusion or rearrangement found by immunohistochemistry, PCR, FISH or NGS. Examples: PD-L1, MSI, HER2/Neu, TMB, BRAF, KRAS, EGFR, ALK.

Main reasons for not taking part

  • ECOG PS > 2
  • Abnormal organ function
  • Hospice enrollment

Read by machine on 12 November 2026.

Where in United States

  • Albuquerque, New MexicoHospital not named in the registryContact: Fiona EvansTaking people
  • Ann Arbor, MichiganHospital not named in the registryContact: Fiona EvansTaking people
  • Atlanta, GeorgiaHospital not named in the registryContact: Fiona EvansTaking people
  • Aurora, ColoradoHospital not named in the registryContact: Fiona EvansTaking people
  • Baltimore, MarylandHospital not named in the registryContact: Fiona EvansTaking people
  • Bethesda, MarylandHospital not named in the registryContact: Fiona EvansTaking people
  • Billings, MontanaHospital not named in the registryContact: Fiona EvansTaking people
  • Birmingham, AlabamaHospital not named in the registryContact: Fiona EvansTaking people
  • Boise, IdahoHospital not named in the registryContact: Fiona EvansTaking people
  • Buffalo, New YorkHospital not named in the registryContact: Fiona EvansTaking people
  • Chapel Hill, North CarolinaHospital not named in the registryContact: Fiona EvansTaking people
  • Charlottesville, VirginiaHospital not named in the registryContact: Fiona EvansTaking people
  • Chicago, IllinoisHospital not named in the registryContact: Fiona EvansTaking people
  • Cincinnati, OhioHospital not named in the registryContact: Fiona EvansTaking people
  • Columbus, OhioHospital not named in the registryContact: Fiona EvansTaking people
  • Dallas, TexasHospital not named in the registryContact: Fiona EvansTaking people
  • Denver, ColoradoHospital not named in the registryContact: Fiona EvansTaking people
  • Duarte, CaliforniaHospital not named in the registryContact: Fiona EvansTaking people
  • Duluth, MinnesotaHospital not named in the registryContact: Fiona EvansTaking people
  • Fargo, North DakotaHospital not named in the registryContact: Fiona EvansTaking people
  • Greenville, South CarolinaHospital not named in the registryContact: Fiona EvansTaking people
  • Hartford, ConnecticutHospital not named in the registryContact: Fiona EvansTaking people
  • Hattiesburg, MississippiHospital not named in the registryContact: Fiona EvansTaking people
  • Hempstead, New YorkHospital not named in the registryContact: Fiona EvansTaking people
  • Houston, TexasHospital not named in the registryContact: Fiona EvansTaking people
  • Iowa City, IowaHospital not named in the registryContact: Fiona EvansTaking people
  • Irvine, CaliforniaHospital not named in the registryContact: Fiona EvansTaking people
  • Jacksonville, FloridaHospital not named in the registryContact: Fiona EvansTaking people
  • Kansas City, MissouriHospital not named in the registryContact: Fiona EvansTaking people
  • La Jolla, CaliforniaHospital not named in the registryContact: Fiona EvansTaking people
  • Lansing, MichiganHospital not named in the registryContact: Fiona EvansTaking people
  • Little Rock, ArkansasHospital not named in the registryContact: Fiona EvansTaking people
  • Littleton, ColoradoHospital not named in the registryContact: Fiona EvansTaking people
  • Manhasset, New YorkHospital not named in the registryContact: Fiona EvansTaking people
  • Mayfield Heights, OhioHospital not named in the registryContact: Fiona EvansTaking people
  • Memphis, TennesseeHospital not named in the registryContact: Fiona EvansTaking people
  • Miami, FloridaHospital not named in the registryContact: Fiona EvansTaking people
  • Milwaukee, WisconsinHospital not named in the registryContact: Fiona EvansTaking people
  • Mobile, AlabamaHospital not named in the registryContact: Fiona EvansTaking people
  • Morgantown, West VirginiaHospital not named in the registryContact: Fiona EvansTaking people
  • Nashville, TennesseeHospital not named in the registryContact: Fiona EvansTaking people
  • New Brunswick, New JerseyHospital not named in the registryContact: Fiona EvansTaking people
  • New Orleans, LouisianaHospital not named in the registryContact: Fiona EvansTaking people
  • New YorkHospital not named in the registryContact: Fiona EvansTaking people
  • Newark, DelawareHospital not named in the registryContact: Fiona EvansTaking people
  • Norwalk, ConnecticutHospital not named in the registryContact: Fiona EvansTaking people
  • Omaha, NebraskaHospital not named in the registryContact: Fiona EvansTaking people
  • Orange, CaliforniaHospital not named in the registryContact: Fiona EvansTaking people
  • Philadelphia, PennsylvaniaHospital not named in the registryContact: Fiona EvansTaking people
  • Portland, OregonHospital not named in the registryContact: Fiona EvansTaking people
  • Providence, Rhode IslandHospital not named in the registryContact: Fiona EvansTaking people
  • Salt Lake City, UtahHospital not named in the registryContact: Fiona EvansTaking people
  • San Francisco, CaliforniaHospital not named in the registryContact: Fiona EvansTaking people
  • Savannah, GeorgiaHospital not named in the registryContact: Fiona EvansTaking people
  • Scarborough, MaineHospital not named in the registryContact: Fiona EvansTaking people
  • Scottsdale, ArizonaHospital not named in the registryContact: Fiona EvansTaking people
  • Seattle, WashingtonHospital not named in the registryContact: Fiona EvansTaking people
  • Silver Spring, MarylandHospital not named in the registryContact: Fiona EvansTaking people
  • St Louis, MissouriHospital not named in the registryContact: Fiona EvansTaking people
  • Stanford, CaliforniaHospital not named in the registryContact: Fiona EvansTaking people
  • Staten Island, New YorkHospital not named in the registryContact: Fiona EvansTaking people
  • Tampa, FloridaHospital not named in the registryContact: Fiona EvansTaking people
  • Temple, TexasHospital not named in the registryContact: Fiona EvansTaking people
  • Towson, MarylandHospital not named in the registryContact: Fiona EvansTaking people
  • Tulsa, OklahomaHospital not named in the registryContact: Fiona EvansTaking people
  • Winston-Salem, North CarolinaHospital not named in the registryContact: Fiona EvansTaking people
  • Worcester, MassachusettsHospital not named in the registryContact: Fiona EvansTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it
Massive Bio, Inc.
Trial code
NCT03452774
Record updated
28 October 2025
Original description
International registry for cancer patients evaluating the feasibility and clinical utility of an Artificial Intelligence-based precision oncology clinical trial matching tool, powered by a virtual tumor boards (VTB) program, and its clinical impact on pts with advanced cancer to facilitate clinical trial enrollment (CTE), as well as the financial impact, and potential outcomes of the intervention.Read full original descriptionShow less

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

International registry for cancer patients evaluating the feasibility and clinical utility of an Artificial Intelligence-based precision oncology clinical trial matching tool, powered by a virtual tumor boards (VTB) program, and its clinical impact on pts with advanced cancer to facilitate clinical trial enrollment (CTE), as well as the financial impact, and potential outcomes of the intervention.

Inclusion: Pts with solid and hematological malignancies; Pts cancer-related biomarkers, gene variants, fusion and rearrangements (by immunohistochemistry, PCR, FISH or NGS): PD-L1, MSI (MMR), Claudin18.2, HER2/Neu, Tumor mutational burden/load (TMB), ABL1, ACVR1B, AKT1, AKT2, AKT3, ALK, APC, AR, ATM, ATRX, AURKA, AURKB, BAP1, BCL2, BCL6, BRAF, BRCA1, BRCA2, BTK, CCND1, CCND2, CCND3, CDK4, CDK6, CDKN1A/B, CEBPA, CHEK1, CHEK2, CSF1R, CTNNB1, DAXX, DDR1/2, DNMT3A, EGFR, ERBB2, ERBB3, ERBB4, ERCC4, ER, ESR1, FANCA, FAS, FBXW7, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, GATA3, GATA6, GNAS, HDAC1, HGF, HRAS, IDH1, IDH2, IGF1R, JAK1, JAK2, JAK3, KDR (VEGFR2), KIT, KRAS, MAP2K2 (MEK2), MAP3K1, MCL1, MDM2, MDM4, MEN1, MET, MSH2, MSH3, MSH6, MTOR, MUTYH, MYC, MYCL (MYCL1), NF1, NF2, NOTCH1, NPM1, NRAS, NTRK1, NTRK2, NTRK3, PALB2, PARP1, PARP2, PARP3, PBRM1, PDCD1 (PD1), PDCD1LG2 (PD-L2), PDGFRA, PDGFRB, PIK3C, PMS2, POLD1, POLE, PRDM1, PTCH1, PTEN, RAF1, RB1, RET, RICTOR, ROS1, RPTOR, SDHA/B/C, SMAD, SMARC, SMO, STK11, TGFBR2, TP53, TSC1, TSC2, VEGFA, VHL, WT1, ZNF217, ZNF703, CEACAM, NRG1, among others; These biomarkers should be determined by local laboratory, external vendor, or next generation sequencing platform; Decision to consider clinical trial pre-screening enrollment (CTE) by primary provider and/or patient.

Exclusion: ECOG PS > 2; Abnormal organ function; Hospice enrollment.

ClinicalTrials.gov NCT03452774