Unicompartmental Knee Arthroplasty (UKA) Versus Total Knee Arthroplasty (TKA) of Medial Osteoarthritis
Key facts
- Who runs it
- Ottawa Hospital Research Institute
- Where
- Canada1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Withdrawn
- Started
- Jan 2021
- Ended
- Sept 2025
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Total Knee Arthroplasty (TKA)
- Unicompartmental Knee Arthroplasty (UKA)
- Record updated
- 2 July 2021
- Why it stopped
- Lack of study funding
Who can take part
- Age
- 50 years to 80 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
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Who can take part
- Who report that most of their pain (greater than 75%) is located in the medial part of the knee on a regular basis
- With active range of motion from 10° of extension to 100° of flexion
- With an intact, competent, anterior cruciate ligament
- With overall limb alignment correctable to neutral, indicating a competent medial collateral ligament
- With radiographs showing primarily bone-on-bone disease in the medial compartment with minimal wear in both the lateral and patellofemoral compartments of the knee
- 50 to 80 years of age
- With a Body Mass Index (BMI) less than 40; For the secondary outcome of motion analysis, only patients exhibiting the following characteristics will be suitable for assessment:
- BMI of 35 or less
- No other ipsilateral or contralateral lower limb joint disorders
Who cannot take part
- Those with inflammatory arthritis
- Those with no fixed address
- Those unable to commit to study requirements and follow-ups
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
This study allows patients to take part of the decision making between a unicompartment knee (partial ) or a total Knee replacement . Using the measures of a decision aid questionnaire which explicitly details the risks and benefits of both procedures.The study will use subjective (reported by patient) and objective data (which will be measured) to allow the determination if one option is superior to the other. Information gathered from this study will be used to assist future patients in selecting the surgical option that best fits their life style.
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A feasibility pilot study of a randomized clinical trial will help to evaluate the outcomes of both procedures and help shape a multicentre Canadian study.
The 2 groups in the trial
- Total Knee Arthroplasty (TKA)Existing treatment, for comparison
In total (complete) knee arthroplasty (TKA), the orthopaedic surgeon removes the damaged areas of the knee and replaces the components with an artificial joint that is made of plastic or metal.
- Unicompartmental Knee Arthroplasty (UKA)Treatment being tested
Unicompartment (partial) knee arthroplasty (UKA) has been available for over 40 years and differs from TKA in that only the most affected and symptomatic compartment (most commonly medial, but occasionally lateral and patella femoral) are replaced
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- A Randomized Trial Comparing Outcomes of Unicompartmental and Total Knee Replacement for Isolated Medial Osteoarthritis: A Feasibility Study
- Record updated
- 2 July 2021