Tests mevrometostat with enzalutamide in men with castration resistant prostate cancer
Tests mevrometostat, alone or with enzalutamide, in men whose prostate cancer kept growing after treatment.
Plain-language title generated from the registry record
Registry title: A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma
Key facts
- Where
- Haskovo, Plovdiv, Ruse, and Vratsa, BulgariaSee the 4 sites
- Phase
- Phase 1
Where in Bulgaria
- Specialized Hospital for Active Treatment of Oncology - Haskovo EOODHaskovo, BulgariaNo longer taking part
- Complex Oncological Center - Plovdiv, EOODPlovdiv, BulgariaNo longer taking part
- Complex Oncology Center Ruse EOODRuse, BulgariaNo longer taking part
- Complex Oncology Center Vratsa EOODVratsa, BulgariaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Pfizer
- Trial code
- NCT03460977EU 2023-509179-18-00
- Record updated
- 15 October 2026
- Original description
The purpose of this study is to learn about the safety and effects of the study medicine (called Mevrometostat) for the possible treatment of Relapsed/ Refractory Small Cell Lung Cancer (SCLC), Castration Resistant Prostate Cancer (CRPC) and Follicular Lymphoma (FL). The study consists of 3 parts; Part 1 and 2 enrolled participants with SCLC, metastatic CRPC, and FL are closed for enrollment.Read full original descriptionShow less
A PHASE I DOSE ESCALATION AND EXPANDED COHORT STUDY OF PF 06821497 (MEVROMETOSTAT) IN THE TREATMENT OF ADULT PATIENTS WITH RELAPSED/REFRACTORY SMALL CELL LUNG CANCER (SCLC), CASTRATION RESISTANT PROSTATE CANCER (CRPC) AND FOLLICULAR LYMPHOMA (FL)
The purpose of this study is to learn about the safety and effects of the study medicine (called Mevrometostat) for the possible treatment of Relapsed/ Refractory Small Cell Lung Cancer (SCLC), Castration Resistant Prostate Cancer (CRPC) and Follicular Lymphoma (FL). The study consists of 3 parts; Part 1 and 2 enrolled participants with SCLC, metastatic CRPC, and FL are closed for enrollment.
Part 3, which is open for enrollment is seeking men who:
* have Castration Resistant Prostate Cancer (CRPC) and * have previously received treatment for CRPC and have progressed from the last treatment
All participants in Part 3 of this study will receive mevrometostat and/ or enzalutamide. Part 3 consists of 2 sub studies each has an assessment phase and a maintenance phase. The Part 3 DDI substudy consist of 2 cohorts, Cohort 1 (monotherapy cohort) and Cohort 2 (Combination cohort).
In the assessment phase:
* participants in the BE substudy will take 3 single doses of mevrometostat by mouth over 3 periods. * participants in the DDI substudy Cohort 1 (monotherapy cohort) will take mevrometostat 2 times a day and/or itraconazole 1 time a day based on a present schedule. * participants in the DDI substudy Cohort 2 (combination cohort) will take mevrometostat 2 times a day, enzalutamide 1 time a day, and/or itraconazole 1 time a day based on a present schedule.
After completion of the assessment phase, participants will enter the maintenance phase where they will receive mevrometostat 2 times a day and enzalutamide 1 time a day by mouth until their cancer is no longer responding.
The study will look at the experiences of participanrs receiving the study medicine. This will help see if the study medicine is safe and effective.
Part 1 and Part 2 (Closed for enrollment); Part 3 Key Inclusion Criteria:; Histological or cytological diagnosis of castration resistant prostate cancer; Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0-2 with expected life expectancy of at least 6 months; Adequate bone marrow, renal, and liver function; Part 3 Key Exclusion Criteria:; Prior irradiation to >25% of the bone marrow; QTcF interval >480 msec at screening; Hypertension that cannot be controlled by medications (>150/90 mmHg despite optimal medical therapy); Known or suspected hypersensitivity to PF 06821497 or any components or enzalutamide (CRPC); Active inflammatory gastrointestinal disease, chronic diarrhea, known diverticular disease or previous gastric resection or lap band surgery; Current use or anticipated need for food or drugs that are known strong and moderate CYP3A4/5 inducers or inhibitors; Prior enzalutamide within the last 4 weeks; DDI SUBSTUDY:; history of CHF or evidence of ventricular dysfunction; fructose intolerance; coadministration of CYP3A4 substrates.