Studies how bariatric surgery affects how the body processes hydrochlorothiazide
Observes how weight-loss surgery changes the body's handling of hydrochlorothiazide in adults with severe obesity.
Plain-language title generated from the registry record
Registry title: Bariatric Surgery and Pharmacokinetics of Hydrochlorothiazide
Key facts
- Where
- Trondheim, NorwaySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT03476551, who can take part
Where in Norway
- St. Olavs University HospitalTrondheim, NorwayTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Norwegian University of Science and Technology
- Trial code
- NCT03476551
- Record updated
- 8 July 2026
- Original description
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on hydrochlorothiazide are investigated.Read full original descriptionShow less
Bariatric Surgery and Pharmacokinetics Hydrochlorothiazide: BAR-MEDS Hydrochlorothiazide
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on hydrochlorothiazide are investigated.
Inclusion: Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway; Being a Norwegian citizen.
Exclusion: Having previously undergone resections in the GI-tract.