A Causative Role for Amylin in Diabetic Peripheral Neuropathy
Key facts
- Who runs it
- Zabeen Mahuwala, MD
- Where
- Lexington, United StatesSee the 2 sites
- Trial code
- Status
- Recruiting
- People taking part
- 40 people, planned
- Started
- 5 Feb 2018
- Expected to end
- Jan 2029
- Type of study
- Observational
- Record updated
- 30 January 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 4 criteriaShow less
Who can take part
- Subject has been diagnosed with Type-2 Diabetes
- Subject shows mild-to-severe peripheral neuropathy, as determined by Nerve Conduction Velocity (NCV) tests
Who cannot take part
- Subject has not been diagnosed with Type-2 Diabetes
- Subject shows average, or above average performance on Nerve Conduction Velocity (NCV) tests
Where in United States
- University of Kentucky - Kentucky Neuroscience InstituteLexington, United StatesContact: Rani Priyanka Vasireddy, MBBS, MHATaking people
- UK Robert Straus Behavioral Science LaboratoryLexington, United StatesContact: Rani Priyanka Vasireddy, MBBS, MHANo longer taking part
About the trial
What the trial wants to find out
Three pieces of information lead to the basis for this study:
Read full original descriptionShow less
1. Individuals with Type-2 diabetes commonly develop peripheral neuropathy. 2. Increased production of the hormone amylin occurs in individuals who have Type-2 diabetes. 3. Aggregations of amylin was found in the peripheral vasculature of rats that overexpressed human amylin.
The purpose of this study is to determine whether a correlation exists between the amount of amylin present in the upper extremities of human subjects with Type-2 diabetes and the extent to which symptoms of peripheral neuropathy are expressed in those subjects. The investigators will be testing this by initially collecting blood and skin biopsy samples from subjects, followed by measuring patient sensation and pain responses to heat, cold, and pressure in the upper extremities.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 30 January 2026