Ovarian tissue transplant for infertility after cancer treatment
Tests transplanting a woman's own frozen ovarian tissue after chemotherapy or radiation caused ovarian failure.
Key facts
- Who runs it
- University of Pittsburgh
- Where
- Pittsburgh, United StatesSee the site
- Trial code
- Registry title
- Autologous Ovarian Tissue Transplantation
- Status
- Recruiting
- People taking part
- 5 people, planned
- Started
- 1 Mar 2021
- Expected to end
- 1 Sept 2030
- Type of study
- Interventional
- Treatments tested
- Ovarian tissue transplant
- Record updated
- 9 July 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for women who froze their own ovarian tissue earlier. They now have ovaries that stopped working after chemotherapy and/or radiation, or they want to become pregnant. The trial puts this tissue back into the body.
- Age
- 18 Years to 45 Years
- Sex
- Women only
- Disease stage
- Ovaries that do not work well enough (ovarian insufficiency), and/or wanting to become pregnant. People must be in good health.
- Earlier treatment
- Must have ovarian tissue that was frozen earlier. Must have clearance from their cancer doctor (oncologist).
- Biomarker or test result
- Women with BRCA mutations cannot join.
Main reasons for not taking part
- High risk of problems from surgery
- A medical reason not to become pregnant, if the goal is pregnancy
- Past leukemia, ovarian cancer, or a cancer that likely reached the ovaries when the tissue was collected
- A condition that stops the person from giving fully informed consent
- Being pregnant now
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Previously cryopreserved ovarian tissue
- Ovarian insufficiency and/or candidate for pregnancy
- Good health
- Oncologist's clearance
Who cannot take part
- Patients considered to be high risk for surgical complications
- Women with a history of leukemia, ovarian cancer or a cancer that likely involved ovaries at the time of ovarian tissue collection
- Women with psychological, psychiatric, or other conditions which prevent giving fully informed consent
- Women with contraindication for pregnancy if goal is to achieve pregnancy
- Women positive for the BRCA mutations
- Current pregnancy
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 45 years old?
Where in United States
- Magee-Womens HospitalPittsburgh, United StatesContact: Jennifer AnglinTaking people
About the trial
What the trial wants to find out
Chemotherapy and radiation for cancer and other conditions can cause infertility. Several centers around the world are cryopreserving ovarian tissue from these patients though an experimental protocol, including the Fertility Preservation Program in Pittsburgh (protocol PRO08050491). The objective of this study is to study the efficacy and safety of autologous tissue transplantation in patients diagnosed with primary ovarian insufficiency after chemotherapy and/or radiation treatments.
The group in the trial
- Ovarian tissue transplantTreatment being tested
Transplantation of ovarian tissue into the abdomen. Only for patients who have previously frozen ovarian tissue
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Autologous Ovarian Tissue Transplantation
- Plain-language title
- Ovarian tissue transplant for infertility after cancer treatmentGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 15 November 2026.
- Fit questions
- Built from NCT03496636, who can take part
- Record updated
- 9 July 2026