NCT03516279Active, not recruitingPhase 2
Pembrolizumab and Dasatinib, Imatinib Mesylate, or Nilotinib in Treating Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease
Phase II Study of Adding the Anti-PD-1 Pembrolizumab to Tyrosine Kinase Inhibitors in Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease
Source: ClinicalTrials.gov · Last updated 15 Sept 2026
Brief summary (registry, in English)
This phase II trial studies how well pembrolizumab and dasatinib, imatinib mesylate, or nilotinib work in treating patients with chronic myeloid leukemia and persistent detection of minimal residual disease, defined as the levels of a gene product called bcr-abl in the blood. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of cancer cells to grow and spread. Dasatinib, imatinib mesylate, and nilotinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving pembrolizumab and dasatinib, imatinib mesylate, or nilotinib may work better in treating patients with chronic myeloid leukemia.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 24 Apr 2018
- Start date
- 26 Jun 2019
- Primary completion date
- 31 Aug 2028
- Lead sponsor
- ECOG-ACRIN Cancer Research Group
- Diseases
- Chronic myeloid leukaemia
- NCT number
- NCT03516279
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 40
- From 26 Jun 2019 to the primary completion date, 31 Aug 2028
- 291 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- PREREGISTRATION (STEP 0): Patient has pathologically-confirmed chronic phase-CML on a first line TKI and must meet the following criteria:
- The patient has to be on first-line TKI therapy (the same TKI) for at least 2 years prior to pre-registration
- Has been in MMR (i.e. MR\^3) but still have detectable BCR-ABL transcript by a standard real-time quantitative polymerase chain reaction (RQ-PCR) assay with a limit of detection (sensitivity) of 4.5 for at least 12 months from the first documentation of the MMR
- Patient has not achieved MR\^4.5 (complete molecular remission \[CMR\]) within the time of initiation of TKI therapy and pre-registration
- PREREGISTRATION (STEP 0): Patient must be scheduled to undergo a standard of care bone marrow biopsy within 7 days of step 0 registration
- PREREGISTRATION (STEP 0): Peripheral blood must be collected for submission to Fred Hutchinson Cancer Research Center for central assessment of the establishment of BCR/ABL status to confirm patient?s eligibility for registration to Step 1; Fred Hutchinson will forward results within 1-2 business days of receipt of the peripheral blood to the submitting institution
- REGISTRATION TO TREATMENT (STEP 1): Institution has received central BCR-ABL test results confirming MRD positive status
- REGISTRATION TO TREATMENT (STEP 1): Patients have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1
- REGISTRATION TO TREATMENT (STEP 1): No active hemolytic anemia requiring immunosuppressive therapy or other pharmacologic treatment; patients who have a positive Coombs test but no evidence of hemolysis are NOT excluded from participation
- REGISTRATION TO TREATMENT (STEP 1): No current use of corticosteroids; EXCEPTION: Low doses of steroids (\< 10 mg of prednisone or equivalent dose of other steroid) used for treatment of non-hematologic medical condition (e.g. chronic adrenal insufficiency) is permitted
- REGISTRATION TO TREATMENT (STEP 1): No other active primary malignancy (other than non-melanomatous skin cancer or carcinoma in situ of the cervix) requiring treatment or limiting expected survival to =\< 2 years
- NOTE: If there is a history of prior malignancy, they must not be receiving other specific treatment (other than hormonal therapy for their cancer)
- REGISTRATION TO TREATMENT (STEP 1): Women must not be pregnant or breastfeeding; patients must also not expect to conceive or father children from the time of registration, while on study treatment, and continue for 120 days after the last dose of study treatment; all females of childbearing potential must have a negative urine or serum pregnancy within 72 hours prior to receiving the first dose of pembrolizumab; if the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- REGISTRATION TO TREATMENT (STEP 1): Women of childbearing potential and sexually active males must use an accepted and effective method of contraception or to abstain from sexual from time of registration, while on study treatment, and continue for 120 days after the last dose of study treatment
- REGISTRATION TO TREATMENT (STEP 1): Patients must have been on a stable dose of the TKI for the last 3 months prior to pre-registration
- REGISTRATION TO TREATMENT (STEP 1): Patient may not be currently participating and receiving study therapy or have participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment
- REGISTRATION TO TREATMENT (STEP 1): Patient must not have a diagnosis of immunodeficiency or be receiving systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of treatment
- REGISTRATION TO TREATMENT (STEP 1): Patient must not have a known history of active TB (Bacillus Tuberculosis)
- REGISTRATION TO TREATMENT (STEP 1): Patient must not have a history of hypersensitivity to pembrolizumab or any of its excipients
- REGISTRATION TO TREATMENT (STEP 1): Patient must not have received a prior anti-cancer monoclonal antibody (mAb) within 4 weeks prior to study registration or have not recovered (i.e., =\< grade 1 or at baseline) from adverse events due to agents administered more than 4 weeks earlier
- REGISTRATION TO TREATMENT (STEP 1): Patient must not have had prior chemotherapy, targeted small molecule therapy (aside from imatinib, dasatinib, or nilotinib), or radiation therapy within 2 weeks prior to study registration; patients also must have recovered from all adverse events due to a previously administered agent
- Note: Patients with =\< grade 2 neuropathy are an exception to this criterion and may qualify for the study
- REGISTRATION TO TREATMENT (STEP 1): Patients who have received major surgery must have recovered adequately from the toxicity and/or complications from the intervention prior to starting therapy
- REGISTRATION TO TREATMENT (STEP 1): Patient must not have a known additional malignancy that is progressing or requires active treatment; exceptions include basal cell carcinoma of the skin or squamous cell carcinoma of the skin that has undergone potentially curative therapy or in situ cervical cancer
- REGISTRATION TO TREATMENT (STEP 1): Patient must not have known active central nervous system (CNS) metastases and/or carcinomatous meningitis; subjects with previously treated brain metastases may participate provided they are stable (without evidence of progression by imaging for at least four weeks prior to the first dose of protocol treatment and any neurologic symptoms have returned to baseline), have no evidence of new or enlarging brain metastases, and are not using steroids for at least 7 days prior to protocol treatment; this exception does not include carcinomatous meningitis which is excluded regardless of clinical stability
- REGISTRATION TO TREATMENT (STEP 1): Patient must not have active autoimmune disease that has required systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs); replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment
- REGISTRATION TO TREATMENT (STEP 1): Patient must not have known history of, or any evidence of active, non-infectious pneumonitis
- REGISTRATION TO TREATMENT (STEP 1): Patient must not have an active infection requiring systemic therapy
- REGISTRATION TO TREATMENT (STEP 1): Patient must not have a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate, in the opinion of the treating investigator
- REGISTRATION TO TREATMENT (STEP 1): Patient must not have known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial
- REGISTRATION TO TREATMENT (STEP 1): Patient must not have received prior therapy with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent
- REGISTRATION TO TREATMENT (STEP 1): Patients who are Human Immunodeficiency Virus (HIV) positive are eligible if they have undetectable HIV viral load and CD4+ T-cell count ≥ 250/mm3.
- REGISTRATION TO TREATMENT (STEP 1): Patients with a known positive test for Hepatitis C virus ribonucleic acid (HCV antibody) indicating acute or chronic infection might be enrolled if the viral load by PCR is undetectable with/without active treatment.
- REGISTRATION TO TREATMENT (STEP 1): Patients must not have known history of hepatitis B (defined as Hepatitis B surface antigen \[HBsAg\] reactive).
- REGISTRATION TO TREATMENT (STEP 1): Patient must not have received a live vaccine within 30 days of planned start of study therapy
- NOTE: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed
- REGISTRATION TO TREATMENT (STEP 1): Absolute neutrophil count (ANC) \>= 1,500 /mcL, within 14 days prior to first dose of pembrolizumab
- REGISTRATION TO TREATMENT (STEP 1): Platelet count \>= 100,000 /mcL, within 14 days prior to first dose of pembrolizumab
- REGISTRATION TO TREATMENT (STEP 1): Hemoglobin (Hgb) \>= 9 g/dL OR \>= 5.6 mmol/L without transfusion of erythropoietin (EPO) dependency, within 14 days prior to first dose of pembrolizumab
- REGISTRATION TO TREATMENT (STEP 1): Serum creatinine =\< 1.5 X upper limit of normal (ULN) OR creatinine clearance (per institutional standards) \>= 60 mL/min for patient with creatinine levels \> 1.5 X ULN, within 14 days prior to first dose of pembrolizumab
- REGISTRATION TO TREATMENT (STEP 1): Serum total bilirubin =\< 1.5 X ULN OR direct bilirubin
- =\< ULN for subjects with total bilirubin levels \> 1.5 X ULN, within 14 days prior to first dose of pembrolizumab
- REGISTRATION TO TREATMENT (STEP 1): Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \[SGOT\]) and alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase \[SGPT\]) =\< 2.5 X ULN OR =\< 5 X ULN for subjects with liver metastases, within 14 days prior to first dose of pembrolizumab
- REGISTRATION TO TREATMENT (STEP 1): Patients should not be receiving concomitant strong CYP3A4 inducers or inhibitors ≤ 7 days prior to registration due to their potential to effect the activity or pharmacokinetics of study agents and/or QT interval prolongation toxicity. Should treatment with any of these agents be required, consult with study chair.
- REGISTRATION TO TREATMENT (STEP 1): Patients should not have received prior allogeneic transplant.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (291)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hickman Cancer Center Coordinator of this site? Confirm its status | Adrian | United States | Unknown status |
| Saint Anthony's Health Coordinator of this site? Confirm its status | Alton | United States | Unknown status |
| McFarland Clinic - Ames Coordinator of this site? Confirm its status | Ames | United States | Unknown status |
| Mary Greeley Medical Center Coordinator of this site? Confirm its status | Ames | United States | Unknown status |
| Community Hospital of Anaconda Coordinator of this site? Confirm its status | Anaconda | United States | Unknown status |
| Mission Cancer and Blood - Ankeny Coordinator of this site? Confirm its status | Ankeny | United States | Unknown status |
| ThedaCare Regional Cancer Center Coordinator of this site? Confirm its status | Appleton | United States | Unknown status |
| Mission Hope Medical Oncology - Arroyo Grande Coordinator of this site? Confirm its status | Arroyo Grande | United States | Unknown status |
| Rocky Mountain Cancer Centers-Aurora Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Rush-Copley Medical Center Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Baker City Coordinator of this site? Confirm its status | Baker City | United States | Unknown status |
| Saint Louis Cancer and Breast Institute-Ballwin Coordinator of this site? Confirm its status | Ballwin | United States | Unknown status |
| Saint Agnes Hospital Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Flaget Memorial Hospital Coordinator of this site? Confirm its status | Bardstown | United States | Unknown status |
| Nebraska Medicine-Bellevue Coordinator of this site? Confirm its status | Bellevue | United States | Unknown status |
| Billings Clinic Cancer Center Coordinator of this site? Confirm its status | Billings | United States | Unknown status |
| Illinois CancerCare-Bloomington Coordinator of this site? Confirm its status | Bloomington | United States | Unknown status |
| Prisma Health Cancer Institute - Spartanburg Coordinator of this site? Confirm its status | Boiling Springs | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Boise Coordinator of this site? Confirm its status | Boise | United States | Unknown status |
| Central Care Cancer Center - Bolivar Coordinator of this site? Confirm its status | Bolivar | United States | Unknown status |
| Parkland Health Center-Bonne Terre Coordinator of this site? Confirm its status | Bonne Terre | United States | Unknown status |
| McFarland Clinic - Boone Coordinator of this site? Confirm its status | Boone | United States | Unknown status |
| Rocky Mountain Cancer Centers-Boulder Coordinator of this site? Confirm its status | Boulder | United States | Unknown status |
| Boulder Community Foothills Hospital Coordinator of this site? Confirm its status | Boulder | United States | Unknown status |
| Bozeman Health Deaconess Hospital Coordinator of this site? Confirm its status | Bozeman | United States | Unknown status |
| Cox Cancer Center Branson Coordinator of this site? Confirm its status | Branson | United States | Unknown status |
| Harrison HealthPartners Hematology and Oncology-Bremerton Coordinator of this site? Confirm its status | Bremerton | United States | Unknown status |
| Saint Joseph Regional Cancer Center Coordinator of this site? Confirm its status | Bryan | United States | Unknown status |
| Highline Medical Center-Main Campus Coordinator of this site? Confirm its status | Burien | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Caldwell Coordinator of this site? Confirm its status | Caldwell | United States | Unknown status |
| Illinois CancerCare-Canton Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Saint Francis Medical Center Coordinator of this site? Confirm its status | Cape Girardeau | United States | Unknown status |
| Southeast Cancer Center Coordinator of this site? Confirm its status | Cape Girardeau | United States | Unknown status |
| Memorial Hospital of Carbondale Coordinator of this site? Confirm its status | Carbondale | United States | Unknown status |
| Mercy Cancer Center - Carmichael Coordinator of this site? Confirm its status | Carmichael | United States | Unknown status |
| Mercy San Juan Medical Center Coordinator of this site? Confirm its status | Carmichael | United States | Unknown status |
| Saint Anthony Regional Hospital Coordinator of this site? Confirm its status | Carroll | United States | Unknown status |
| SIH Cancer Institute Coordinator of this site? Confirm its status | Carterville | United States | Unknown status |
| Illinois CancerCare-Carthage Coordinator of this site? Confirm its status | Carthage | United States | Unknown status |
| Rocky Mountain Cancer Centers - Centennial Coordinator of this site? Confirm its status | Centennial | United States | Unknown status |
| Centralia Oncology Clinic Coordinator of this site? Confirm its status | Centralia | United States | Unknown status |
| Saint Mary's Hospital Coordinator of this site? Confirm its status | Centralia | United States | Unknown status |
| Christiana Care Health System-Concord Health Center Coordinator of this site? Confirm its status | Chadds Ford | United States | Unknown status |
| Memorial Hospital Coordinator of this site? Confirm its status | Chattanooga | United States | Unknown status |
| Saint Luke's Hospital Coordinator of this site? Confirm its status | Chesterfield | United States | Unknown status |
| Cheyenne Regional Medical Center-West Coordinator of this site? Confirm its status | Cheyenne | United States | Unknown status |
| University of Illinois Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Northwestern University Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Good Samaritan Hospital - Cincinnati Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| TriHealth Cancer Institute-Anderson Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Bethesda North Hospital Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| TriHealth Cancer Institute-Westside Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| MetroHealth Medical Center Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| Prisma Health Cancer Institute - Laurens Coordinator of this site? Confirm its status | Clinton | United States | Unknown status |
| Southeastern Medical Oncology Center-Clinton Coordinator of this site? Confirm its status | Clinton | United States | Unknown status |
| Mercy Cancer Center-West Lakes Coordinator of this site? Confirm its status | Clive | United States | Unknown status |
| Mission Cancer and Blood - West Des Moines Coordinator of this site? Confirm its status | Clive | United States | Unknown status |
| Billings Clinic-Cody Coordinator of this site? Confirm its status | Cody | United States | Unknown status |
| Kootenai Health - Coeur d'Alene Coordinator of this site? Confirm its status | Coeur d'Alene | United States | Unknown status |
| Rocky Mountain Cancer Centers-Penrose Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| Saint Francis Cancer Center Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| Penrose-Saint Francis Healthcare Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| Commonwealth Cancer Center-Corbin Coordinator of this site? Confirm its status | Corbin | United States | Unknown status |
| Alegent Health Mercy Hospital Coordinator of this site? Confirm its status | Council Bluffs | United States | Unknown status |
| Greater Regional Medical Center Coordinator of this site? Confirm its status | Creston | United States | Unknown status |
| Geisinger Medical Center Coordinator of this site? Confirm its status | Danville | United States | Unknown status |
| Carle at The Riverfront Coordinator of this site? Confirm its status | Danville | United States | Unknown status |
| Decatur Memorial Hospital Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Cancer Care Specialists of Illinois - Decatur Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Colorado Blood Cancer Institute Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Rocky Mountain Cancer Centers-Rose Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| The Women's Imaging Center Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Porter Adventist Hospital Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Rose Medical Center Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Presbyterian - Saint Lukes Medical Center - Health One Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Rocky Mountain Cancer Centers-Midtown Coordinator of this site? Confirm its status | Denver | United States | Unknown status |
| Smilow Cancer Hospital-Derby Care Center Coordinator of this site? Confirm its status | Derby | United States | Unknown status |
| Broadlawns Medical Center Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Mission Cancer and Blood - Laurel Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Iowa Methodist Medical Center Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Mission Cancer and Blood - Des Moines Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Mercy Medical Center - Des Moines Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Iowa Lutheran Hospital Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Illinois CancerCare-Dixon Coordinator of this site? Confirm its status | Dixon | United States | Unknown status |
| Southwest Oncology PC Coordinator of this site? Confirm its status | Durango | United States | Unknown status |
| Mercy Medical Center Coordinator of this site? Confirm its status | Durango | United States | Unknown status |
| Prisma Health Cancer Institute - Easley Coordinator of this site? Confirm its status | Easley | United States | Unknown status |
| Mayo Clinic Health System Eau Claire Hospital-Luther Campus Coordinator of this site? Confirm its status | Eau Claire | United States | Unknown status |
| Mayo Clinic Health System-Eau Claire Clinic Coordinator of this site? Confirm its status | Eau Claire | United States | Unknown status |
| Marshfield Medical Center-EC Cancer Center Coordinator of this site? Confirm its status | Eau Claire | United States | Unknown status |
| Crossroads Cancer Center Coordinator of this site? Confirm its status | Effingham | United States | Unknown status |
| Carle Physician Group-Effingham Coordinator of this site? Confirm its status | Effingham | United States | Unknown status |
| Mercy Cancer Center - Elk Grove Coordinator of this site? Confirm its status | Elk Grove | United States | Unknown status |
| Walter Knox Memorial Hospital Coordinator of this site? Confirm its status | Emmett | United States | Unknown status |
| Rocky Mountain Cancer Centers - Swedish Coordinator of this site? Confirm its status | Englewood | United States | Unknown status |
| Swedish Medical Center Coordinator of this site? Confirm its status | Englewood | United States | Unknown status |
| Mountain Blue Cancer Care Center - Swedish Coordinator of this site? Confirm its status | Englewood | United States | Unknown status |
| The Melanoma and Skin Cancer Institute Coordinator of this site? Confirm its status | Englewood | United States | Unknown status |
| Saint Elizabeth Hospital Coordinator of this site? Confirm its status | Enumclaw | United States | Unknown status |
| Illinois CancerCare-Eureka Coordinator of this site? Confirm its status | Eureka | United States | Unknown status |
| Fairbanks Memorial Hospital Coordinator of this site? Confirm its status | Fairbanks | United States | Unknown status |
| Smilow Cancer Hospital Care Center-Fairfield Coordinator of this site? Confirm its status | Fairfield | United States | Unknown status |
| Parkland Health Center - Farmington Coordinator of this site? Confirm its status | Farmington | United States | Unknown status |
| Saint Francis Hospital Coordinator of this site? Confirm its status | Federal Way | United States | Unknown status |
| McFarland Clinic - Trinity Cancer Center Coordinator of this site? Confirm its status | Fort Dodge | United States | Unknown status |
| Trinity Regional Medical Center Coordinator of this site? Confirm its status | Fort Dodge | United States | Unknown status |
| Mercy Hospital Fort Smith Coordinator of this site? Confirm its status | Fort Smith | United States | Unknown status |
| Beebe South Coastal Health Campus Coordinator of this site? Confirm its status | Frankford | United States | Unknown status |
| Vanderbilt-Ingram Cancer Center Cool Springs Coordinator of this site? Confirm its status | Franklin | United States | Unknown status |
| Illinois CancerCare-Galesburg Coordinator of this site? Confirm its status | Galesburg | United States | Unknown status |
| Western Illinois Cancer Treatment Center Coordinator of this site? Confirm its status | Galesburg | United States | Unknown status |
| Central Care Cancer Center - Garden City Coordinator of this site? Confirm its status | Garden City | United States | Unknown status |
| Smilow Cancer Hospital Care Center at Glastonbury Coordinator of this site? Confirm its status | Glastonbury | United States | Unknown status |
| Mountain Blue Cancer Care Center Coordinator of this site? Confirm its status | Golden | United States | Unknown status |
| Southeastern Medical Oncology Center-Goldsboro Coordinator of this site? Confirm its status | Goldsboro | United States | Unknown status |
| Wayne Memorial Hospital Coordinator of this site? Confirm its status | Goldsboro | United States | Unknown status |
| CTCA at Western Regional Medical Center Coordinator of this site? Confirm its status | Goodyear | United States | Unknown status |
| Nebraska Cancer Specialists/Oncology Hematology West PC Coordinator of this site? Confirm its status | Grand Island | United States | Unknown status |
| Central Care Cancer Center - Great Bend Coordinator of this site? Confirm its status | Great Bend | United States | Unknown status |
| Benefis Sletten Cancer Institute Coordinator of this site? Confirm its status | Great Falls | United States | Unknown status |
| Great Falls Clinic Coordinator of this site? Confirm its status | Great Falls | United States | Unknown status |
| Prisma Health Cancer Institute - Faris Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Prisma Health Cancer Institute - Butternut Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| BI-LO Charities Children's Cancer Center Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Prisma Health Cancer Institute - Eastside Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Prisma Health Greenville Memorial Hospital Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Prisma Health Cancer Institute - Greer Coordinator of this site? Confirm its status | Greer | United States | Unknown status |
| Smilow Cancer Hospital Care Center - Guilford Coordinator of this site? Confirm its status | Guilford | United States | Unknown status |
| Smilow Cancer Hospital Care Center at Saint Francis Coordinator of this site? Confirm its status | Hartford | United States | Unknown status |
| Geisinger Medical Center-Cancer Center Hazleton Coordinator of this site? Confirm its status | Hazleton | United States | Unknown status |
| Saint Peter's Community Hospital Coordinator of this site? Confirm its status | Helena | United States | Unknown status |
| Pulmonary Medicine Center of Chattanooga-Hixson Coordinator of this site? Confirm its status | Hixson | United States | Unknown status |
| CHI Saint Vincent Cancer Center Hot Springs Coordinator of this site? Confirm its status | Hot Springs | United States | Unknown status |
| Southeastern Medical Oncology Center-Jacksonville Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Onslow Memorial Hospital Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| McFarland Clinic - Jefferson Coordinator of this site? Confirm its status | Jefferson | United States | Unknown status |
| MU Health Care Goldschmidt Cancer Center Coordinator of this site? Confirm its status | Jefferson City | United States | Unknown status |
| Freeman Health System Coordinator of this site? Confirm its status | Joplin | United States | Unknown status |
| Mercy Hospital Joplin Coordinator of this site? Confirm its status | Joplin | United States | Unknown status |
| Kalispell Regional Medical Center Coordinator of this site? Confirm its status | Kalispell | United States | Unknown status |
| Heartland Hematology and Oncology Coordinator of this site? Confirm its status | Kearney | United States | Unknown status |
| CHI Health Good Samaritan Coordinator of this site? Confirm its status | Kearney | United States | Unknown status |
| Illinois CancerCare-Kewanee Clinic Coordinator of this site? Confirm its status | Kewanee | United States | Unknown status |
| Marshfield Medical Center - Ladysmith Coordinator of this site? Confirm its status | Ladysmith | United States | Unknown status |
| Northwestern Medicine Lake Forest Hospital Coordinator of this site? Confirm its status | Lake Forest | United States | Unknown status |
| Saint Clare Hospital Coordinator of this site? Confirm its status | Lakewood | United States | Unknown status |
| Rocky Mountain Cancer Centers-Lakewood Coordinator of this site? Confirm its status | Lakewood | United States | Unknown status |
| Saint Anthony Hospital Coordinator of this site? Confirm its status | Lakewood | United States | Unknown status |
| Lawrence Memorial Hospital Coordinator of this site? Confirm its status | Lawrence | United States | Unknown status |
| Cancer Centers of Southwest Oklahoma Research Coordinator of this site? Confirm its status | Lawton | United States | Unknown status |
| Beebe Medical Center Coordinator of this site? Confirm its status | Lewes | United States | Unknown status |
| Geisinger Medical Oncology-Lewisburg Coordinator of this site? Confirm its status | Lewisburg | United States | Unknown status |
| Lewistown Hospital Coordinator of this site? Confirm its status | Lewistown | United States | Unknown status |
| Saint Joseph Hospital East Coordinator of this site? Confirm its status | Lexington | United States | Unknown status |
| Saint Joseph Hospital Coordinator of this site? Confirm its status | Lexington | United States | Unknown status |
| Saint Joseph Radiation Oncology Resource Center Coordinator of this site? Confirm its status | Lexington | United States | Unknown status |
| Saint Elizabeth Regional Medical Center Coordinator of this site? Confirm its status | Lincoln | United States | Unknown status |
| CARTI Cancer Center Coordinator of this site? Confirm its status | Little Rock | United States | Unknown status |
| Rocky Mountain Cancer Centers-Littleton Coordinator of this site? Confirm its status | Littleton | United States | Unknown status |
| Littleton Adventist Hospital Coordinator of this site? Confirm its status | Littleton | United States | Unknown status |
| Saint Joseph London Coordinator of this site? Confirm its status | London | United States | Unknown status |
| Rocky Mountain Cancer Centers-Sky Ridge Coordinator of this site? Confirm its status | Lone Tree | United States | Unknown status |
| Longmont United Hospital Coordinator of this site? Confirm its status | Longmont | United States | Unknown status |
| Rocky Mountain Cancer Centers-Longmont Coordinator of this site? Confirm its status | Longmont | United States | Unknown status |
| UofL Health Medical Center Northeast Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Jewish Hospital Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Saints Mary and Elizabeth Hospital Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| Illinois CancerCare-Macomb Coordinator of this site? Confirm its status | Macomb | United States | Unknown status |
| McFarland Clinic - Marshalltown Coordinator of this site? Confirm its status | Marshalltown | United States | Unknown status |
| Marshfield Medical Center-Marshfield Coordinator of this site? Confirm its status | Marshfield | United States | Unknown status |
| Contra Costa Regional Medical Center Coordinator of this site? Confirm its status | Martinez | United States | Unknown status |
| Sovah Health Martinsville Coordinator of this site? Confirm its status | Martinsville | United States | Unknown status |
| Carle Physician Group-Mattoon/Charleston Coordinator of this site? Confirm its status | Mattoon | United States | Unknown status |
| Toledo Clinic Cancer Centers-Maumee Coordinator of this site? Confirm its status | Maumee | United States | Unknown status |
| Mercy Cancer Center Coordinator of this site? Confirm its status | Merced | United States | Unknown status |
| Idaho Urologic Institute-Meridian Coordinator of this site? Confirm its status | Meridian | United States | Unknown status |
| Garnet Health Medical Center Coordinator of this site? Confirm its status | Middletown | United States | Unknown status |
| Medical College of Wisconsin Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
| Marshfield Clinic-Minocqua Center Coordinator of this site? Confirm its status | Minocqua | United States | Unknown status |
| Community Medical Center Coordinator of this site? Confirm its status | Missoula | United States | Unknown status |
| Toledo Clinic Cancer Centers-Monroe Coordinator of this site? Confirm its status | Monroe | United States | Unknown status |
| West Virginia University Healthcare Coordinator of this site? Confirm its status | Morgantown | United States | Unknown status |
| Morristown Medical Center Coordinator of this site? Confirm its status | Morristown | United States | Unknown status |
| Saint Joseph Mount Sterling Coordinator of this site? Confirm its status | Mount Sterling | United States | Unknown status |
| Good Samaritan Regional Health Center Coordinator of this site? Confirm its status | Mount Vernon | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Nampa Coordinator of this site? Confirm its status | Nampa | United States | Unknown status |
| Vanderbilt University/Ingram Cancer Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| Vanderbilt Breast Center at One Hundred Oaks Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| Christiana Care Health System-Christiana Hospital Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
| Delaware Clinical and Laboratory Physicians PA Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
| Medical Oncology Hematology Consultants PA Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
| Helen F Graham Cancer Center Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
| Froedtert and MCW Moorland Reserve Health Center Coordinator of this site? Confirm its status | New Berlin | United States | Unknown status |
| Yale University Coordinator of this site? Confirm its status | New Haven | United States | Unknown status |
| Smilow Cancer Center/Yale-New Haven Hospital Coordinator of this site? Confirm its status | New Haven | United States | Unknown status |
| Yale-New Haven Hospital North Haven Medical Center Coordinator of this site? Confirm its status | North Haven | United States | Unknown status |
| Cancer Care Center of O'Fallon Coordinator of this site? Confirm its status | O'Fallon | United States | Unknown status |
| Mercy Hospital Oklahoma City Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| University of Oklahoma Health Sciences Center Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| Alegent Health Immanuel Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Alegent Health Bergan Mercy Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| University of Nebraska Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Creighton University Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Hematology and Oncology Consultants PC Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Alegent Health Lakeside Hospital Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Nebraska Medicine-Village Pointe Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Ontario Coordinator of this site? Confirm its status | Ontario | United States | Unknown status |
| Memorial GYN Plus Coordinator of this site? Confirm its status | Ooltewah | United States | Unknown status |
| Lake Regional Hospital Coordinator of this site? Confirm its status | Osage Beach | United States | Unknown status |
| Illinois CancerCare-Ottawa Clinic Coordinator of this site? Confirm its status | Ottawa | United States | Unknown status |
| Mercy Health-Paducah Medical Oncology and Hematology Coordinator of this site? Confirm its status | Paducah | United States | Unknown status |
| Midlands Community Hospital Coordinator of this site? Confirm its status | Papillion | United States | Unknown status |
| Rocky Mountain Cancer Centers-Parker Coordinator of this site? Confirm its status | Parker | United States | Unknown status |
| Parker Adventist Hospital Coordinator of this site? Confirm its status | Parker | United States | Unknown status |
| Illinois CancerCare-Pekin Coordinator of this site? Confirm its status | Pekin | United States | Unknown status |
| Methodist Medical Center of Illinois Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Illinois CancerCare-Peoria Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Mercy Health Perrysburg Cancer Center Coordinator of this site? Confirm its status | Perrysburg | United States | Unknown status |
| Valley Radiation Oncology Coordinator of this site? Confirm its status | Peru | United States | Unknown status |
| Illinois CancerCare-Peru Coordinator of this site? Confirm its status | Peru | United States | Unknown status |
| Cancer Center at Saint Joseph's Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Jefferson Healthcare Coordinator of this site? Confirm its status | Port Townsend | United States | Unknown status |
| Kootenai Clinic Cancer Services - Post Falls Coordinator of this site? Confirm its status | Post Falls | United States | Unknown status |
| Geisinger Cancer Services-Pottsville Coordinator of this site? Confirm its status | Pottsville | United States | Unknown status |
| Harrison HealthPartners Hematology and Oncology-Poulsbo Coordinator of this site? Confirm its status | Poulsbo | United States | Unknown status |
| Illinois CancerCare-Princeton Coordinator of this site? Confirm its status | Princeton | United States | Unknown status |
| Saint Mary Corwin Medical Center Coordinator of this site? Confirm its status | Pueblo | United States | Unknown status |
| Rocky Mountain Cancer Centers - Pueblo Coordinator of this site? Confirm its status | Pueblo | United States | Unknown status |
| Beebe Health Campus Coordinator of this site? Confirm its status | Rehoboth Beach | United States | Unknown status |
| Marshfield Medical Center-Rice Lake Coordinator of this site? Confirm its status | Rice Lake | United States | Unknown status |
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Mercy Cancer Center - Rocklin Coordinator of this site? Confirm its status | Rocklin | United States | Unknown status |
| Mercy Clinic-Rolla-Cancer and Hematology Coordinator of this site? Confirm its status | Rolla | United States | Unknown status |
| Delbert Day Cancer Institute at PCRMC Coordinator of this site? Confirm its status | Rolla | United States | Unknown status |
| Mercy Cancer Center - Sacramento Coordinator of this site? Confirm its status | Sacramento | United States | Unknown status |
| Coborn Cancer Center at Saint Cloud Hospital Coordinator of this site? Confirm its status | Saint Cloud | United States | Unknown status |
| Sainte Genevieve County Memorial Hospital Coordinator of this site? Confirm its status | Sainte Genevieve | United States | Unknown status |
| Heartland Regional Medical Center Coordinator of this site? Confirm its status | Saint Joseph | United States | Unknown status |
| Kootenai Clinic Cancer Services - Sandpoint Coordinator of this site? Confirm its status | Sandpoint | United States | Unknown status |
| Pacific Central Coast Health Center-San Luis Obispo Coordinator of this site? Confirm its status | San Luis Obispo | United States | Unknown status |
| Mission Hope Medical Oncology - Santa Maria Coordinator of this site? Confirm its status | Santa Maria | United States | Unknown status |
| Community Medical Center Coordinator of this site? Confirm its status | Scranton | United States | Unknown status |
| TidalHealth Nanticoke / Allen Cancer Center Coordinator of this site? Confirm its status | Seaford | United States | Unknown status |
| Geisinger Medical Oncology-Selinsgrove Coordinator of this site? Confirm its status | Selinsgrove | United States | Unknown status |
| Prisma Health Cancer Institute - Seneca Coordinator of this site? Confirm its status | Seneca | United States | Unknown status |
| Jewish Hospital Medical Center South Coordinator of this site? Confirm its status | Shepherdsville | United States | Unknown status |
| Welch Cancer Center Coordinator of this site? Confirm its status | Sheridan | United States | Unknown status |
| Saint Michael Cancer Center Coordinator of this site? Confirm its status | Silverdale | United States | Unknown status |
| Springfield Clinic Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Memorial Medical Center Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Mercy Hospital Springfield Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Southern Illinois University School of Medicine Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| CoxHealth South Hospital Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Geisinger Medical Group Coordinator of this site? Confirm its status | State College | United States | Unknown status |
| Marshfield Medical Center-River Region at Stevens Point Coordinator of this site? Confirm its status | Stevens Point | United States | Unknown status |
| Mercy Hospital Saint Louis Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Mercy Hospital South Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Saint Louis Cancer and Breast Institute-South City Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Missouri Baptist Medical Center Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Missouri Baptist Sullivan Hospital Coordinator of this site? Confirm its status | Sullivan | United States | Unknown status |
| Overlook Hospital Coordinator of this site? Confirm its status | Summit | United States | Unknown status |
| BJC Outpatient Center at Sunset Hills Coordinator of this site? Confirm its status | Sunset Hills | United States | Unknown status |
| Southwest Illinois Health Services LLP Coordinator of this site? Confirm its status | Swansea | United States | Unknown status |
| Franciscan Research Center-Northwest Medical Plaza Coordinator of this site? Confirm its status | Tacoma | United States | Unknown status |
| Northwest Medical Specialties PLLC Coordinator of this site? Confirm its status | Tacoma | United States | Unknown status |
| Rocky Mountain Cancer Centers-Thornton Coordinator of this site? Confirm its status | Thornton | United States | Unknown status |
| Mercy Health - Saint Anne Hospital Coordinator of this site? Confirm its status | Toledo | United States | Unknown status |
| Toledo Clinic Cancer Centers-Toledo Coordinator of this site? Confirm its status | Toledo | United States | Unknown status |
| Smilow Cancer Hospital-Torrington Care Center Coordinator of this site? Confirm its status | Torrington | United States | Unknown status |
| Smilow Cancer Hospital Care Center-Trumbull Coordinator of this site? Confirm its status | Trumbull | United States | Unknown status |
| Oklahoma Cancer Specialists and Research Institute-Tulsa Coordinator of this site? Confirm its status | Tulsa | United States | Unknown status |
| Carle Cancer Center Coordinator of this site? Confirm its status | Urbana | United States | Unknown status |
| The Carle Foundation Hospital Coordinator of this site? Confirm its status | Urbana | United States | Unknown status |
| BASS Medical Group - Lennon Coordinator of this site? Confirm its status | Walnut Creek | United States | Unknown status |
| Illinois CancerCare - Washington Coordinator of this site? Confirm its status | Washington | United States | Unknown status |
| Mercy Hospital Washington Coordinator of this site? Confirm its status | Washington | United States | Unknown status |
| Smilow Cancer Hospital-Waterbury Care Center Coordinator of this site? Confirm its status | Waterbury | United States | Unknown status |
| Smilow Cancer Hospital Care Center - Waterford Coordinator of this site? Confirm its status | Waterford | United States | Unknown status |
| Marshfield Clinic-Wausau Center Coordinator of this site? Confirm its status | Wausau | United States | Unknown status |
| Methodist West Hospital Coordinator of this site? Confirm its status | West Des Moines | United States | Unknown status |
| Mercy Medical Center-West Lakes Coordinator of this site? Confirm its status | West Des Moines | United States | Unknown status |
| Marshfield Medical Center - Weston Coordinator of this site? Confirm its status | Weston | United States | Unknown status |
| Cancer Center of Kansas - Wichita Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
| Wesley Medical Center Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
| Cancer Center of Kansas-Wichita Medical Arts Tower Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
| Ascension Via Christi Hospitals Wichita Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
| Geisinger Wyoming Valley/Henry Cancer Center Coordinator of this site? Confirm its status | Wilkes-Barre | United States | Unknown status |
| Christiana Care Health System-Wilmington Hospital Coordinator of this site? Confirm its status | Wilmington | United States | Unknown status |
| Marshfield Clinic - Wisconsin Rapids Center Coordinator of this site? Confirm its status | Wisconsin Rapids | United States | Unknown status |
| Woodland Memorial Hospital Coordinator of this site? Confirm its status | Woodland | United States | Unknown status |
| Rush-Copley Healthcare Center Coordinator of this site? Confirm its status | Yorkville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.