Imaging Heart Changes With a Radioactive Tracer in Heart Disease
Tests a radioactive tracer scan of the heart in adults with aortic stenosis or diabetes.
Plain-language title generated from the registry record
Registry title: Imaging Histone Deacetylase in the Heart
Key facts
- Where
- Boston, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT03549559, who can take part
Where in United States
- Massachusetts General HospitalBoston, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Massachusetts General Hospital
- Trial code
- NCT03549559
- Record updated
- 22 December 2025
- Original description
The overall goal of this PET-MR imaging trial is to evaluate 11C-Martinostat, a histone deacetylase targeted radioligand, in patients with aortic stenosis, individuals with diabetes, and healthy volunteers.Read full original descriptionShow less
Imaging of Histone Deacetylase in the Heart
The overall goal of this PET-MR imaging trial is to evaluate 11C-Martinostat, a histone deacetylase targeted radioligand, in patients with aortic stenosis, individuals with diabetes, and healthy volunteers.
Inclusion: Group 1: Healthy Volunteers (n = 30); Healthy adults with no known history of medical disease; Age 18-85 years; No history cardiovascular disease; Ability to provide informed consent; Group 2: Patients with Diabetes (n = 16); Age 18-85 years; Diagnosis of diabetes; Echocardiogram within last 12 months showing no evidence of left ventricular hypertrophy or hemodynamic findings consistent with heart failure with preserved ejection fraction; Ability to provide informed consent; Group 3: Patients with Aortic Stenosis (n = 50); Age 18-85 years; Echocardiogram or cardiac MRI scan within last 12 months documenting left ventricular hypertrophy and degenerative calcific aortic stenosis; Ability to provide informed consent.
Exclusion: Known contraindication to MRI.