Under construction – not a live service
Sign in
SuspendedPhase 2/3

Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery

Reason given: End of Initial Phase of Multi-phase protocol

Key facts

Where
‘Aiea, Aberdeen, Albuquerque, Allentown, Altamonte Springs, Altoona, Anchorage, Ann Arbor, Appleton, Arroyo Grande, Ashland, Atlanta, Aventura, Ballwin, Bangor, Bath, Beaver, Beavercreek, Bellevue, Bellingham, Bemidji, Bend, Berlin Corners, Bethlehem, Biddeford, Bismarck, Bloomington, Boardman, Boise, Bolivar, Boston, Brainerd, Brewer, Brick, Bridgeport, Brighton, Bryan, Burbank, Burien, Burlington, Burnsville, Butler, Camp Hill, Canandaigua, Canton, Cape Girardeau, Carbondale, Carlisle, Carmel, Caro, Carterville, Carthage, Centerville, Centralia, Chadds Ford, Charleston, Charlotte, Charlottesville, Chelsea, Chicago, Cincinnati, City of Saint Peters, Clackamas, Cleveland, Clive, Clovis, Collierville, Colorado Springs, Columbus, Coon Rapids, Coos Bay, Creston, Creve Coeur, Dallas, Dansville, Danville, Dayton, Decatur, Deer River, Denver, Des Moines, Detroit, Detroit Lakes, Dixon, Duluth, East Greenwich, East Stroudsburg, Easton, Eau Claire, Edina, Edmonds, Effingham, Erie, Eureka, Everett, Fargo, Farmington, Farrell, Fergus Falls, Findlay, Flint, Fond du Lac, Fort Lauderdale, Fort Myers, Fort Smith, Fort Worth, Fosston, Franklin, Fridley, Fruitland, Gainesville, Galesburg, Garden City, Germantown, Glens Falls, Grafton, Grand Island, Great Bend, Green Bay, Greensburg, Greenville, Grenada, Grosse Pointe Woods, Harrisburg, Hayward, Henderson, Hershey, Hibbing, Hines, Honolulu, Hot Springs, Huntersville, Independence, Indiana, Indianapolis, Issaquah, Jamestown, Jefferson City, Jefferson Hills, Johnson Creek, Johnstown, Jonesboro, Joplin, Kearney, Kenner, Kenosha, Kernersville, Kettering, Kewanee, Kissimmee, Lacey, Lake Forest, Lake Success, Lakewood, Lansing, Las Vegas, Lebanon, Lewes, Lewisburg, Lexington, Lihue, Littleton, Livonia, Long Branch, Longmont, Longview, Los Angeles, Louisville, Lowell, Macomb, Madison, Manahawkin, Mansfield, Maple Grove, Maplewood, Marinette, Marlette, Marshfield, Matthews, Mayfield Heights, Maywood, McKeesport, Memphis, Meridian, Miami Beach, Middletown, Millville, Milwaukee, Minneapolis, Minocqua, Missoula, Monroeville, Monticello, Moon Township, Mooresville, Morgantown, Mount Airy, Mount Pleasant, Mount Vernon, N. Huntingdon, Nampa, Nashville, Natrona Heights, Neptune City, New Albany, New Brunswick, New Castle, New Orleans, New Richmond, New York, Newark, Newberg, Newport, North Wilkesboro, Novi, O'Fallon, Oklahoma City, Omaha, Orlando, Oshkosh, Ottawa, Oxford, Palo Alto, Park Rapids, Parker, Parkersburg, Pekin, Peoria, Peru, Philadelphia, Phoenix, Pittsburgh, Pontiac, Portland, Pottstown, Princeton, Providence, Pueblo, Racine, Red Bank, Rehoboth Beach, Reno, Renton, Rice Lake, Richardson, Richmond, Rio Rancho, Robbinsdale, Rochester, Rolla, Sacramento, Saginaw, Saint Johnsbury, Saint Joseph, Saint Louis Park, Saint Paul, Sainte Genevieve, Salisbury, Salt Lake City, San Luis Obispo, Sandstone, Sandusky, Sanford, Santa Maria, Savannah, Scarborough, Seaford, Seattle, Sedro-Woolley, Seneca, Shakopee, Sheboygan, Silverdale, Sioux Falls, South Hill, South Portland, Southfield, Southhaven, Spooner, Springfield, St Louis, St. Helena, Statesville, Stevens Point, Stillwater, Strongsville, Sturgeon Bay, Sullivan, Summit, Superior, Sylvania, Syracuse, Tacoma, Tawas City, The Bronx, Thomasville, Toledo, Toms River, Troy, Twin Falls, Two Rivers, Uniontown, Vancouver, Virginia, Waconia, Walla Walla, Warren, Warrensville Heights, Washington, Washington D.C., Wauwatosa, West Allis, West Branch, West Chester, West Des Moines, West Mifflin, West Reading, Weston, Wexford, Whittier, Willmar, Winston-Salem, Woodbury, Woodland, Wooster, Yakima, York, Youngstown, and Ypsilanti, United StatesSee the 488 sites
Phase
Phase 2/3

Where in United States

  • Hawaii Cancer Care - Westridge‘Aiea, United StatesNo longer taking part
  • Pali Momi Medical Center‘Aiea, United StatesNo longer taking part
  • Queen's Cancer Center - Pearlridge‘Aiea, United StatesNo longer taking part
  • The Cancer Center of Hawaii-Pali Momi‘Aiea, United StatesNo longer taking part
  • Providence Regional Cancer System-AberdeenAberdeen, United StatesNo longer taking part
  • Lovelace Medical Center-Saint Joseph SquareAlbuquerque, United StatesNo longer taking part
  • New Mexico Oncology Hematology ConsultantsAlbuquerque, United StatesNo longer taking part
  • Presbyterian Kaseman HospitalAlbuquerque, United StatesNo longer taking part
  • University of New Mexico Cancer CenterAlbuquerque, United StatesNo longer taking part
  • Lehigh Valley Hospital-Cedar CrestAllentown, United StatesNo longer taking part
  • Saint Luke's Cancer Center - AllentownAllentown, United StatesNo longer taking part
  • AdventHealth AltamonteAltamonte Springs, United StatesNo longer taking part
  • UPMC AltoonaAltoona, United StatesNo longer taking part
  • Alaska Breast Care and Surgery LLCAnchorage, United StatesNo longer taking part
  • Alaska Oncology and Hematology LLCAnchorage, United StatesNo longer taking part
  • Alaska Women's Cancer CareAnchorage, United StatesNo longer taking part
  • Anchorage Associates in Radiation MedicineAnchorage, United StatesNo longer taking part
  • Anchorage Oncology CentreAnchorage, United StatesNo longer taking part
  • Katmai Oncology GroupAnchorage, United StatesNo longer taking part
  • Providence Alaska Medical CenterAnchorage, United StatesNo longer taking part
  • Trinity Health Saint Joseph Mercy Hospital Ann ArborAnn Arbor, United StatesNo longer taking part
  • ThedaCare Regional Cancer CenterAppleton, United StatesNo longer taking part
  • PCR OncologyArroyo Grande, United StatesNo longer taking part
  • Duluth Clinic AshlandAshland, United StatesNo longer taking part
  • Northwest Wisconsin Cancer CenterAshland, United StatesNo longer taking part
  • Emory Proton Therapy CenterAtlanta, United StatesNo longer taking part
  • Emory Saint Joseph's HospitalAtlanta, United StatesNo longer taking part
  • Emory University Hospital MidtownAtlanta, United StatesNo longer taking part
  • Emory University Hospital/Winship Cancer InstituteAtlanta, United StatesNo longer taking part
  • Mount Sinai Comprehensive Cancer Center at AventuraAventura, United StatesNo longer taking part
  • Mercy Oncology and Hematology - Clayton-ClarksonBallwin, United StatesNo longer taking part
  • Eastern Maine Medical CenterBangor, United StatesNo longer taking part
  • MaineHealth Coastal Cancer Treatment CenterBath, United StatesNo longer taking part
  • UPMC-Heritage Valley Health System BeaverBeaver, United StatesNo longer taking part
  • Indu and Raj Soin Medical CenterBeavercreek, United StatesNo longer taking part
  • Nebraska Medicine-BellevueBellevue, United StatesNo longer taking part
  • Overlake Medical CenterBellevue, United StatesNo longer taking part
  • PeaceHealth Saint Joseph Medical CenterBellingham, United StatesNo longer taking part
  • Sanford Joe Lueken Cancer CenterBemidji, United StatesNo longer taking part
  • Saint Charles Health SystemBend, United StatesNo longer taking part
  • Central Vermont Medical Center/National Life Cancer TreatmentBerlin Corners, United StatesNo longer taking part
  • Lehigh Valley Hospital - MuhlenbergBethlehem, United StatesNo longer taking part
  • Saint Luke's University Hospital-Bethlehem CampusBethlehem, United StatesNo longer taking part
  • MaineHealth Maine Medical Center - BiddefordBiddeford, United StatesNo longer taking part
  • Sanford Bismarck Medical CenterBismarck, United StatesNo longer taking part
  • Illinois CancerCare-BloomingtonBloomington, United StatesNo longer taking part
  • Saint Elizabeth Boardman HospitalBoardman, United StatesNo longer taking part
  • Saint Luke's Cancer Institute - BoiseBoise, United StatesNo longer taking part
  • Central Care Cancer Center - BolivarBolivar, United StatesNo longer taking part
  • Boston Medical CenterBoston, United StatesNo longer taking part
  • Tufts Medical CenterBoston, United StatesNo longer taking part
  • Essentia Health Saint Joseph's Medical CenterBrainerd, United StatesNo longer taking part
  • Lafayette Family Cancer Center-EMMCBrewer, United StatesNo longer taking part
  • Ocean University Medical CenterBrick, United StatesNo longer taking part
  • United Hospital CenterBridgeport, United StatesNo longer taking part
  • Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, United StatesNo longer taking part
  • Trinity Health Medical Center - BrightonBrighton, United StatesNo longer taking part
  • Saint Joseph Regional Cancer CenterBryan, United StatesNo longer taking part
  • Providence Saint Joseph Medical Center/Disney Family Cancer CenterBurbank, United StatesNo longer taking part
  • Saint Anne HospitalBurien, United StatesNo longer taking part
  • Aurora Cancer Care-Southern Lakes VLCCBurlington, United StatesNo longer taking part
  • University of Vermont and State Agricultural CollegeBurlington, United StatesNo longer taking part
  • University of Vermont Medical CenterBurlington, United StatesNo longer taking part
  • Fairview Ridges HospitalBurnsville, United StatesNo longer taking part
  • Minnesota Oncology - BurnsvilleBurnsville, United StatesNo longer taking part
  • UPMC Hillman Cancer Center at Butler Health SystemButler, United StatesNo longer taking part
  • UPMC Camp HillCamp Hill, United StatesNo longer taking part
  • Sands Cancer CenterCanandaigua, United StatesNo longer taking part
  • Illinois CancerCare-CantonCanton, United StatesNo longer taking part
  • Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, United StatesNo longer taking part
  • Trinity Health Medical Center - CantonCanton, United StatesNo longer taking part
  • Mercy Cancer Center - Cape GirardeauCape Girardeau, United StatesNo longer taking part
  • Saint Francis Medical CenterCape Girardeau, United StatesNo longer taking part
  • Memorial Hospital of CarbondaleCarbondale, United StatesNo longer taking part
  • Carlisle Regional Cancer CenterCarlisle, United StatesNo longer taking part
  • IU Health North HospitalCarmel, United StatesNo longer taking part
  • Caro Cancer CenterCaro, United StatesNo longer taking part
  • SIH Cancer InstituteCarterville, United StatesNo longer taking part
  • Illinois CancerCare-CarthageCarthage, United StatesNo longer taking part
  • Dayton Physicians LLC-Miami Valley SouthCenterville, United StatesNo longer taking part
  • Miami Valley Hospital SouthCenterville, United StatesNo longer taking part
  • Centralia Oncology ClinicCentralia, United StatesNo longer taking part
  • Providence Regional Cancer System-CentraliaCentralia, United StatesNo longer taking part
  • Christiana Care Health System-Concord Health CenterChadds Ford, United StatesNo longer taking part
  • Medical University of South CarolinaCharleston, United StatesNo longer taking part
  • Vandalia Health/CAMC Institute for Academic MedicineCharleston, United StatesNo longer taking part
  • Novant Health Presbyterian Medical CenterCharlotte, United StatesNo longer taking part
  • University of Virginia Cancer CenterCharlottesville, United StatesNo longer taking part
  • Chelsea HospitalChelsea, United StatesNo longer taking part
  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, United StatesNo longer taking part
  • Northwestern UniversityChicago, United StatesNo longer taking part
  • University of IllinoisChicago, United StatesNo longer taking part
  • Bethesda North HospitalCincinnati, United StatesNo longer taking part
  • Good Samaritan Hospital - CincinnatiCincinnati, United StatesNo longer taking part
  • Oncology Hematology Care Inc-KenwoodCincinnati, United StatesNo longer taking part
  • University of Cincinnati Cancer Center-UC Medical CenterCincinnati, United StatesNo longer taking part
  • Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, United StatesNo longer taking part
  • Clackamas Radiation Oncology CenterClackamas, United StatesNo longer taking part
  • Providence Cancer Institute Clackamas ClinicClackamas, United StatesNo longer taking part
  • Cleveland Clinic Cancer Center/Fairview HospitalCleveland, United StatesNo longer taking part
  • Cleveland Clinic FoundationCleveland, United StatesNo longer taking part
  • MetroHealth Medical CenterCleveland, United StatesNo longer taking part
  • Mercy Cancer Center-West LakesClive, United StatesNo longer taking part
  • UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, United StatesNo longer taking part
  • Community Cancer InstituteClovis, United StatesNo longer taking part
  • University Oncology AssociatesClovis, United StatesNo longer taking part
  • Baptist Memorial Hospital and Cancer Center-ColliervilleCollierville, United StatesNo longer taking part
  • Penrose-Saint Francis HealthcareColorado Springs, United StatesNo longer taking part
  • Rocky Mountain Cancer Centers-PenroseColorado Springs, United StatesNo longer taking part
  • Saint Francis Cancer CenterColorado Springs, United StatesNo longer taking part
  • Baptist Memorial Hospital and Cancer Center-Golden TriangleColumbus, United StatesNo longer taking part
  • Ohio State University Comprehensive Cancer CenterColumbus, United StatesNo longer taking part
  • Mercy HospitalCoon Rapids, United StatesNo longer taking part
  • Bay Area HospitalCoos Bay, United StatesNo longer taking part
  • Greater Regional Medical CenterCreston, United StatesNo longer taking part
  • Siteman Cancer Center at West County HospitalCreve Coeur, United StatesNo longer taking part
  • Parkland Memorial HospitalDallas, United StatesNo longer taking part
  • UT Southwestern/Simmons Cancer Center-DallasDallas, United StatesNo longer taking part
  • Noyes Memorial Hospital/Myers Cancer CenterDansville, United StatesNo longer taking part
  • Geisinger Medical CenterDanville, United StatesNo longer taking part
  • Dayton Physician LLC - EnglewoodDayton, United StatesNo longer taking part
  • Miami Valley HospitalDayton, United StatesNo longer taking part
  • Miami Valley Hospital NorthDayton, United StatesNo longer taking part
  • Cancer Care Specialists of Illinois - DecaturDecatur, United StatesNo longer taking part
  • Decatur Memorial HospitalDecatur, United StatesNo longer taking part
  • Essentia Health - Deer River ClinicDeer River, United StatesNo longer taking part
  • AdventHealth PorterDenver, United StatesNo longer taking part
  • Mercy Medical Center - Des MoinesDes Moines, United StatesNo longer taking part
  • UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, United StatesNo longer taking part
  • Henry Ford Health Saint John HospitalDetroit, United StatesNo longer taking part
  • Essentia Health Saint Mary's - Detroit Lakes ClinicDetroit Lakes, United StatesNo longer taking part
  • Illinois CancerCare-DixonDixon, United StatesNo longer taking part
  • Essentia Health Cancer CenterDuluth, United StatesNo longer taking part
  • Essentia Health Saint Mary's Medical CenterDuluth, United StatesNo longer taking part
  • Miller-Dwan HospitalDuluth, United StatesNo longer taking part
  • Rhode Island Hospital at East GreenwichEast Greenwich, United StatesNo longer taking part
  • Pocono Medical CenterEast Stroudsburg, United StatesNo longer taking part
  • Saint Luke's Hospital-Anderson CampusEaston, United StatesNo longer taking part
  • HSHS Sacred Heart HospitalEau Claire, United StatesNo longer taking part
  • Marshfield Medical Center-EC Cancer CenterEau Claire, United StatesNo longer taking part
  • Fairview Southdale HospitalEdina, United StatesNo longer taking part
  • Minnesota Oncology - EdinaEdina, United StatesNo longer taking part
  • Swedish Cancer Institute-EdmondsEdmonds, United StatesNo longer taking part
  • Crossroads Cancer CenterEffingham, United StatesNo longer taking part
  • UPMC Hillman Cancer Center ErieErie, United StatesNo longer taking part
  • Illinois CancerCare-EurekaEureka, United StatesNo longer taking part
  • Providence Regional Cancer PartnershipEverett, United StatesNo longer taking part
  • Essentia Health Cancer Center-South University ClinicFargo, United StatesNo longer taking part
  • Sanford Broadway Medical CenterFargo, United StatesNo longer taking part
  • Sanford Roger Maris Cancer CenterFargo, United StatesNo longer taking part
  • Parkland Health Center - FarmingtonFarmington, United StatesNo longer taking part
  • UPMC Cancer Center at UPMC HorizonFarrell, United StatesNo longer taking part
  • Lake Region Healthcare Corporation-Cancer CareFergus Falls, United StatesNo longer taking part
  • Armes Family Cancer CenterFindlay, United StatesNo longer taking part
  • Blanchard Valley HospitalFindlay, United StatesNo longer taking part
  • Orion Cancer CareFindlay, United StatesNo longer taking part
  • Genesys Hurley Cancer InstituteFlint, United StatesNo longer taking part
  • Hurley Medical CenterFlint, United StatesNo longer taking part
  • Aurora Health Center-Fond du LacFond du Lac, United StatesNo longer taking part
  • Holy Cross HospitalFort Lauderdale, United StatesNo longer taking part
  • Regional Cancer Center-Lee Memorial Health SystemFort Myers, United StatesNo longer taking part
  • Mercy Hospital Fort SmithFort Smith, United StatesNo longer taking part
  • UT Southwestern/Simmons Cancer Center-Fort WorthFort Worth, United StatesNo longer taking part
  • Essentia Health - FosstonFosston, United StatesNo longer taking part
  • Atrium Medical Center-Middletown Regional HospitalFranklin, United StatesNo longer taking part
  • Dayton Physicians LLC-AtriumFranklin, United StatesNo longer taking part
  • Unity HospitalFridley, United StatesNo longer taking part
  • Saint Luke's Cancer Institute - FruitlandFruitland, United StatesNo longer taking part
  • UF Health Cancer Institute - GainesvilleGainesville, United StatesNo longer taking part
  • Illinois CancerCare-GalesburgGalesburg, United StatesNo longer taking part
  • Western Illinois Cancer Treatment CenterGalesburg, United StatesNo longer taking part
  • Central Care Cancer Center - Garden CityGarden City, United StatesNo longer taking part
  • Aurora Health Care Germantown Health CenterGermantown, United StatesNo longer taking part
  • Glens Falls HospitalGlens Falls, United StatesNo longer taking part
  • Aurora Cancer Care-GraftonGrafton, United StatesNo longer taking part
  • Nebraska Cancer Specialists/Oncology Hematology West PCGrand Island, United StatesNo longer taking part
  • Central Care Cancer Center - Great BendGreat Bend, United StatesNo longer taking part
  • Aurora BayCare Medical CenterGreen Bay, United StatesNo longer taking part
  • Bellin Memorial HospitalGreen Bay, United StatesNo longer taking part
  • Saint Vincent Hospital Cancer Center at Saint Mary'sGreen Bay, United StatesNo longer taking part
  • Saint Vincent Hospital Cancer Center Green BayGreen Bay, United StatesNo longer taking part
  • UPMC Cancer Centers - Arnold Palmer PavilionGreensburg, United StatesNo longer taking part
  • Dayton Physicians LLC-WayneGreenville, United StatesNo longer taking part
  • Saint Francis Cancer CenterGreenville, United StatesNo longer taking part
  • Saint Francis HospitalGreenville, United StatesNo longer taking part
  • Wayne HospitalGreenville, United StatesNo longer taking part
  • Baptist Cancer Center-GrenadaGrenada, United StatesNo longer taking part
  • Henry Ford Saint John Hospital - Van ElslanderGrosse Pointe Woods, United StatesNo longer taking part
  • UPMC Pinnacle Cancer Center/Community Osteopathic CampusHarrisburg, United StatesNo longer taking part
  • Essentia Health-Hayward ClinicHayward, United StatesNo longer taking part
  • Comprehensive Cancer Centers of Nevada - HendersonHenderson, United StatesNo longer taking part
  • Oncology Las Vegas - HendersonHenderson, United StatesNo longer taking part
  • Penn State Milton S. Hershey Medical CenterHershey, United StatesNo longer taking part
  • Essentia Health Hibbing ClinicHibbing, United StatesNo longer taking part
  • Edward Hines Jr VA HospitalHines, United StatesNo longer taking part
  • Hawaii Cancer Care Inc - Waterfront PlazaHonolulu, United StatesNo longer taking part
  • Hawaii Cancer Care Inc-LilihaHonolulu, United StatesNo longer taking part
  • Island UrologyHonolulu, United StatesNo longer taking part
  • Kapiolani Medical Center for Women and ChildrenHonolulu, United StatesNo longer taking part
  • Kuakini Medical CenterHonolulu, United StatesNo longer taking part
  • Queen's Cancer Cenrer - POB IHonolulu, United StatesNo longer taking part
  • Queen's Cancer Center - KuakiniHonolulu, United StatesNo longer taking part
  • Queen's Medical CenterHonolulu, United StatesNo longer taking part
  • Straub Clinic and HospitalHonolulu, United StatesNo longer taking part
  • The Cancer Center of Hawaii-LilihaHonolulu, United StatesNo longer taking part
  • University of Hawaii Cancer CenterHonolulu, United StatesNo longer taking part
  • CHI Saint Vincent Cancer Center Hot SpringsHot Springs, United StatesNo longer taking part
  • Novant Health Cancer Institute - HuntersvilleHuntersville, United StatesNo longer taking part
  • Novant Health Presbyterian Medical Center HuntersvilleHuntersville, United StatesNo longer taking part
  • Cleveland Clinic Cancer Center IndependenceIndependence, United StatesNo longer taking part
  • IRMC Cancer CenterIndiana, United StatesNo longer taking part
  • Indiana University/Melvin and Bren Simon Cancer CenterIndianapolis, United StatesNo longer taking part
  • Swedish Cancer Institute-IssaquahIssaquah, United StatesNo longer taking part
  • Essentia Health - Jamestown ClinicJamestown, United StatesNo longer taking part
  • MU Health Care Goldschmidt Cancer CenterJefferson City, United StatesNo longer taking part
  • Jefferson HospitalJefferson Hills, United StatesNo longer taking part
  • University of Wisconsin Carbone Cancer Center - Johnson CreekJohnson Creek, United StatesNo longer taking part
  • UPMC-Johnstown/John P. Murtha Regional Cancer CenterJohnstown, United StatesNo longer taking part
  • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - JonesboroJonesboro, United StatesNo longer taking part
  • Freeman Health SystemJoplin, United StatesNo longer taking part
  • Mercy Hospital JoplinJoplin, United StatesNo longer taking part
  • CHI Health Good SamaritanKearney, United StatesNo longer taking part
  • Ochsner Medical Center KennerKenner, United StatesNo longer taking part
  • Aurora Cancer Care-Kenosha SouthKenosha, United StatesNo longer taking part
  • Novant Health Cancer Institute - KernersvilleKernersville, United StatesNo longer taking part
  • Greater Dayton Cancer CenterKettering, United StatesNo longer taking part
  • Kettering Medical CenterKettering, United StatesNo longer taking part
  • Illinois CancerCare-Kewanee ClinicKewanee, United StatesNo longer taking part
  • AdventHealth KissimmeeKissimmee, United StatesNo longer taking part
  • Providence Regional Cancer System-LaceyLacey, United StatesNo longer taking part
  • Northwestern Medicine Lake Forest HospitalLake Forest, United StatesNo longer taking part
  • Northwell Health/Center for Advanced MedicineLake Success, United StatesNo longer taking part
  • CommonSpirit Saint Anthony Hospital Cancer CenterLakewood, United StatesNo longer taking part
  • University of Michigan Health - Sparrow LansingLansing, United StatesNo longer taking part
  • Alliance for Childhood Diseases/Cure 4 the Kids FoundationLas Vegas, United StatesNo longer taking part
  • Comprehensive Cancer Centers of NevadaLas Vegas, United StatesNo longer taking part
  • Comprehensive Cancer Centers of Nevada - Central ValleyLas Vegas, United StatesNo longer taking part
  • Comprehensive Cancer Centers of Nevada - NorthwestLas Vegas, United StatesNo longer taking part
  • Comprehensive Cancer Centers of Nevada - Town CenterLas Vegas, United StatesNo longer taking part
  • Comprehensive Cancer Centers of Nevada-SummerlinLas Vegas, United StatesNo longer taking part
  • OptumCare Cancer Care at CharlestonLas Vegas, United StatesNo longer taking part
  • OptumCare Cancer Care at Fort ApacheLas Vegas, United StatesNo longer taking part
  • OptumCare Cancer Care at MountainViewLas Vegas, United StatesNo longer taking part
  • Radiation Oncology Centers of Nevada CentralLas Vegas, United StatesNo longer taking part
  • Radiation Oncology Centers of Nevada SoutheastLas Vegas, United StatesNo longer taking part
  • Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, United StatesNo longer taking part
  • Beebe Medical CenterLewes, United StatesNo longer taking part
  • Geisinger Medical Oncology-LewisburgLewisburg, United StatesNo longer taking part
  • CommonSpirit Saint Joseph Hospital - LexingtonLexington, United StatesNo longer taking part
  • CommonSpirit Saint Joseph Medical Center - East LexingtonLexington, United StatesNo longer taking part
  • Saint Joseph Radiation Oncology Resource CenterLexington, United StatesNo longer taking part
  • Wilcox Memorial Hospital and Kauai Medical ClinicLihue, United StatesNo longer taking part
  • AdventHealth LittletonLittleton, United StatesNo longer taking part
  • Trinity Health Saint Mary Mercy Livonia HospitalLivonia, United StatesNo longer taking part
  • Monmouth Medical CenterLong Branch, United StatesNo longer taking part
  • Longmont United HospitalLongmont, United StatesNo longer taking part
  • PeaceHealth Saint John Medical CenterLongview, United StatesNo longer taking part
  • Los Angeles General Medical CenterLos Angeles, United StatesNo longer taking part
  • USC / Norris Comprehensive Cancer CenterLos Angeles, United StatesNo longer taking part
  • Jewish HospitalLouisville, United StatesNo longer taking part
  • UofL Health Medical Center NortheastLouisville, United StatesNo longer taking part
  • Lowell General HospitalLowell, United StatesNo longer taking part
  • Henry Ford Saint John Hospital - Macomb MedicalMacomb, United StatesNo longer taking part
  • Illinois CancerCare-MacombMacomb, United StatesNo longer taking part
  • University of Wisconsin Carbone Cancer Center - University HospitalMadison, United StatesNo longer taking part
  • Southern Ocean County Medical CenterManahawkin, United StatesNo longer taking part
  • Cleveland Clinic Cancer Center MansfieldMansfield, United StatesNo longer taking part
  • Fairview Clinics and Surgery Center Maple GroveMaple Grove, United StatesNo longer taking part
  • Minnesota Oncology Hematology PA-MaplewoodMaplewood, United StatesNo longer taking part
  • Saint John's Hospital - HealtheastMaplewood, United StatesNo longer taking part
  • Aurora Bay Area Medical Group-MarinetteMarinette, United StatesNo longer taking part
  • Saint Mary's Oncology/Hematology Associates of MarletteMarlette, United StatesNo longer taking part
  • Marshfield Medical Center-MarshfieldMarshfield, United StatesNo longer taking part
  • Matthews Radiation Oncology CenterMatthews, United StatesNo longer taking part
  • Novant Health Cancer Institute - MatthewsMatthews, United StatesNo longer taking part
  • Hillcrest Hospital Cancer CenterMayfield Heights, United StatesNo longer taking part
  • Loyola University Medical CenterMaywood, United StatesNo longer taking part
  • UPMC Cancer Center at UPMC McKeesportMcKeesport, United StatesNo longer taking part
  • Baptist Memorial Hospital and Cancer Center-MemphisMemphis, United StatesNo longer taking part
  • Saint Luke's Cancer Institute - MeridianMeridian, United StatesNo longer taking part
  • Mount Sinai Medical CenterMiami Beach, United StatesNo longer taking part
  • Garnet Health Medical CenterMiddletown, United StatesNo longer taking part
  • Beebe South Coastal Health CampusMillville, United StatesNo longer taking part
  • Aurora Cancer Care-MilwaukeeMilwaukee, United StatesNo longer taking part
  • Aurora Saint Luke's Medical CenterMilwaukee, United StatesNo longer taking part
  • Aurora Sinai Medical CenterMilwaukee, United StatesNo longer taking part
  • Abbott-Northwestern HospitalMinneapolis, United StatesNo longer taking part
  • Health Partners IncMinneapolis, United StatesNo longer taking part
  • Hennepin County Medical CenterMinneapolis, United StatesNo longer taking part
  • Marshfield Medical Center - MinocquaMinocqua, United StatesNo longer taking part
  • Saint Patrick Hospital - Community HospitalMissoula, United StatesNo longer taking part
  • Forbes HospitalMonroeville, United StatesNo longer taking part
  • UPMC Cancer Center - MonroevilleMonroeville, United StatesNo longer taking part
  • UPMC Hillman Cancer Center - MonroevilleMonroeville, United StatesNo longer taking part
  • Monticello Cancer CenterMonticello, United StatesNo longer taking part
  • UPMC Hillman Cancer Center in CoraopolisMoon Township, United StatesNo longer taking part
  • Novant Health Cancer Institute - MooresvilleMooresville, United StatesNo longer taking part
  • West Virginia University HealthcareMorgantown, United StatesNo longer taking part
  • Novant Health Cancer Institute - Mount AiryMount Airy, United StatesNo longer taking part
  • UPMC Hillman Cancer Center - Part of Frick HospitalMount Pleasant, United StatesNo longer taking part
  • SSM Health Good SamaritanMount Vernon, United StatesNo longer taking part
  • Arnold Palmer Cancer Center Medical Oncology NorwinN. Huntingdon, United StatesNo longer taking part
  • Saint Luke's Cancer Institute - NampaNampa, United StatesNo longer taking part
  • Vanderbilt University/Ingram Cancer CenterNashville, United StatesNo longer taking part
  • Allegheny Valley HospitalNatrona Heights, United StatesNo longer taking part
  • Jersey Shore Medical CenterNeptune City, United StatesNo longer taking part
  • Baptist Memorial Hospital and Cancer Center-Union CountyNew Albany, United StatesNo longer taking part
  • Rutgers Cancer Institute of New JerseyNew Brunswick, United StatesNo longer taking part
  • UPMC Hillman Cancer Center - New CastleNew Castle, United StatesNo longer taking part
  • Ochsner Medical Center JeffersonNew Orleans, United StatesNo longer taking part
  • Cancer Center of Western WisconsinNew Richmond, United StatesNo longer taking part
  • Laura and Isaac Perlmutter Cancer Center at NYU LangoneNew York, United StatesNo longer taking part
  • NYP/Weill Cornell Medical CenterNew York, United StatesNo longer taking part
  • Christiana Care Health System-Christiana HospitalNewark, United StatesNo longer taking part
  • Delaware Clinical and Laboratory Physicians PANewark, United StatesNo longer taking part
  • Helen F Graham Cancer CenterNewark, United StatesNo longer taking part
  • Medical Oncology Hematology Consultants PANewark, United StatesNo longer taking part
  • Providence Newberg Medical CenterNewberg, United StatesNo longer taking part
  • Newport HospitalNewport, United StatesNo longer taking part
  • Novant Health Cancer Institute - WilkesboroNorth Wilkesboro, United StatesNo longer taking part
  • Henry Ford Health Providence Novi HospitalNovi, United StatesNo longer taking part
  • Cancer Care Center of O'FallonO'Fallon, United StatesNo longer taking part
  • Mercy Hospital Oklahoma CityOklahoma City, United StatesNo longer taking part
  • Alegent Health Bergan Mercy Medical CenterOmaha, United StatesNo longer taking part
  • Alegent Health Immanuel Medical CenterOmaha, United StatesNo longer taking part
  • Alegent Health Lakeside HospitalOmaha, United StatesNo longer taking part
  • Nebraska Medicine-Village PointeOmaha, United StatesNo longer taking part
  • University of Nebraska Medical CenterOmaha, United StatesNo longer taking part
  • AdventHealth East OrlandoOrlando, United StatesNo longer taking part
  • AdventHealth OrlandoOrlando, United StatesNo longer taking part
  • Vince Lombardi Cancer Clinic - OshkoshOshkosh, United StatesNo longer taking part
  • Illinois CancerCare-Ottawa ClinicOttawa, United StatesNo longer taking part
  • Baptist Memorial Hospital and Cancer Center-OxfordOxford, United StatesNo longer taking part
  • Stanford Cancer Institute Palo AltoPalo Alto, United StatesNo longer taking part
  • VA Palo Alto Health Care SystemPalo Alto, United StatesNo longer taking part
  • Essentia Health - Park RapidsPark Rapids, United StatesNo longer taking part
  • AdventHealth ParkerParker, United StatesNo longer taking part
  • Camden Clark Medical CenterParkersburg, United StatesNo longer taking part
  • Illinois CancerCare-PekinPekin, United StatesNo longer taking part
  • OSF Saint Francis Radiation Oncology at PekinPekin, United StatesNo longer taking part
  • Illinois CancerCare-PeoriaPeoria, United StatesNo longer taking part
  • Methodist Medical Center of IllinoisPeoria, United StatesNo longer taking part
  • OSF Saint Francis Medical CenterPeoria, United StatesNo longer taking part
  • OSF Saint Francis Radiation Oncology at Peoria Cancer CenterPeoria, United StatesNo longer taking part
  • Illinois CancerCare-PeruPeru, United StatesNo longer taking part
  • Valley Radiation OncologyPeru, United StatesNo longer taking part
  • University of Pennsylvania/Abramson Cancer CenterPhiladelphia, United StatesNo longer taking part
  • Cancer Center at Saint Joseph'sPhoenix, United StatesNo longer taking part
  • Allegheny General HospitalPittsburgh, United StatesNo longer taking part
  • UPMC Hillman Cancer CenterPittsburgh, United StatesNo longer taking part
  • UPMC-Magee Womens HospitalPittsburgh, United StatesNo longer taking part
  • UPMC-Passavant HospitalPittsburgh, United StatesNo longer taking part
  • UPMC-Saint Clair Hospital Cancer CenterPittsburgh, United StatesNo longer taking part
  • UPMC-Saint MargaretPittsburgh, United StatesNo longer taking part
  • UPMC-Shadyside HospitalPittsburgh, United StatesNo longer taking part
  • West Penn HospitalPittsburgh, United StatesNo longer taking part
  • Michigan Healthcare Professionals PontiacPontiac, United StatesNo longer taking part
  • Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, United StatesNo longer taking part
  • MaineHealth Maine Medical Center - PortlandPortland, United StatesNo longer taking part
  • Providence Portland Medical CenterPortland, United StatesNo longer taking part
  • Providence Saint Vincent Medical CenterPortland, United StatesNo longer taking part
  • Pottstown HospitalPottstown, United StatesNo longer taking part
  • Illinois CancerCare-PrincetonPrinceton, United StatesNo longer taking part
  • Rhode Island HospitalProvidence, United StatesNo longer taking part
  • Saint Mary Corwin Medical CenterPueblo, United StatesNo longer taking part
  • Aurora Cancer Care-RacineRacine, United StatesNo longer taking part
  • Riverview Medical Center/Booker Cancer CenterRed Bank, United StatesNo longer taking part
  • Beebe Health CampusRehoboth Beach, United StatesNo longer taking part
  • Radiation Oncology AssociatesReno, United StatesNo longer taking part
  • Renown Regional Medical CenterReno, United StatesNo longer taking part
  • Saint Mary's Regional Medical CenterReno, United StatesNo longer taking part
  • Valley Medical CenterRenton, United StatesNo longer taking part
  • Marshfield Medical Center-Rice LakeRice Lake, United StatesNo longer taking part
  • UT Southwestern Clinical Center at Richardson/PlanoRichardson, United StatesNo longer taking part
  • Reid HealthRichmond, United StatesNo longer taking part
  • VCU Massey Comprehensive Cancer CenterRichmond, United StatesNo longer taking part
  • Virginia Cancer InstituteRichmond, United StatesNo longer taking part
  • Presbyterian Rust Medical Center/Jorgensen Cancer CenterRio Rancho, United StatesNo longer taking part
  • North Memorial Medical Health CenterRobbinsdale, United StatesNo longer taking part
  • Mayo Clinic in RochesterRochester, United StatesNo longer taking part
  • University of RochesterRochester, United StatesNo longer taking part
  • Mercy Clinic-Rolla-Cancer and HematologyRolla, United StatesNo longer taking part
  • Phelps Health Delbert Day Cancer InstituteRolla, United StatesNo longer taking part
  • Mercy Cancer Center - SacramentoSacramento, United StatesNo longer taking part
  • University of California Davis Comprehensive Cancer CenterSacramento, United StatesNo longer taking part
  • MyMichigan Medical Center SaginawSaginaw, United StatesNo longer taking part
  • Oncology Hematology Associates of Saginaw Valley PCSaginaw, United StatesNo longer taking part
  • Dartmouth Cancer Center - NorthSaint Johnsbury, United StatesNo longer taking part
  • Heartland Regional Medical CenterSaint Joseph, United StatesNo longer taking part
  • Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, United StatesNo longer taking part
  • Regions HospitalSaint Paul, United StatesNo longer taking part
  • United HospitalSaint Paul, United StatesNo longer taking part
  • Sainte Genevieve County Memorial HospitalSainte Genevieve, United StatesNo longer taking part
  • Rowan Regional Medical CenterSalisbury, United StatesNo longer taking part
  • Huntsman Cancer Institute/University of UtahSalt Lake City, United StatesNo longer taking part
  • University of Utah Sugarhouse Health CenterSalt Lake City, United StatesNo longer taking part
  • Pacific Central Coast Health Center-San Luis ObispoSan Luis Obispo, United StatesNo longer taking part
  • Essentia Health SandstoneSandstone, United StatesNo longer taking part
  • North Coast Cancer CareSandusky, United StatesNo longer taking part
  • MaineHealth Cancer Care and IV Therapy - SanfordSanford, United StatesNo longer taking part
  • MaineHealth Cancer Care Center of York CountySanford, United StatesNo longer taking part
  • Mission Hope Medical Oncology - Santa MariaSanta Maria, United StatesNo longer taking part
  • Lewis Cancer and Research Pavilion at Saint Joseph's/CandlerSavannah, United StatesNo longer taking part
  • MaineHealth Maine Medical Center- ScarboroughScarborough, United StatesNo longer taking part
  • TidalHealth Nanticoke / Allen Cancer CenterSeaford, United StatesNo longer taking part
  • Swedish Medical Center-Ballard CampusSeattle, United StatesNo longer taking part
  • Swedish Medical Center-First HillSeattle, United StatesNo longer taking part
  • PeaceHealth United General Medical CenterSedro-Woolley, United StatesNo longer taking part
  • UPMC Cancer Center at UPMC NorthwestSeneca, United StatesNo longer taking part
  • Saint Francis Regional Medical CenterShakopee, United StatesNo longer taking part
  • Vince Lombardi Cancer Clinic-SheboyganSheboygan, United StatesNo longer taking part
  • Saint Joseph Medical Center Hematology and Oncology - SilverdaleSilverdale, United StatesNo longer taking part
  • Avera Cancer InstituteSioux Falls, United StatesNo longer taking part
  • Sanford Cancer Center Oncology ClinicSioux Falls, United StatesNo longer taking part
  • Sanford USD Medical Center - Sioux FallsSioux Falls, United StatesNo longer taking part
  • VCU Community Memorial Health CenterSouth Hill, United StatesNo longer taking part
  • MaineHealth Cancer Care and IV Therapy - South PortlandSouth Portland, United StatesNo longer taking part
  • Henry Ford Health Providence Southfield HospitalSouthfield, United StatesNo longer taking part
  • Baptist Memorial Hospital and Cancer Center-DesotoSouthhaven, United StatesNo longer taking part
  • Essentia Health-Spooner ClinicSpooner, United StatesNo longer taking part
  • CoxHealth South HospitalSpringfield, United StatesNo longer taking part
  • Mercy Hospital SpringfieldSpringfield, United StatesNo longer taking part
  • Southern Illinois University School of MedicineSpringfield, United StatesNo longer taking part
  • Springfield ClinicSpringfield, United StatesNo longer taking part
  • Springfield Memorial HospitalSpringfield, United StatesNo longer taking part
  • Springfield Regional Cancer CenterSpringfield, United StatesNo longer taking part
  • Springfield Regional Medical CenterSpringfield, United StatesNo longer taking part
  • Mercy Hospital Saint LouisSt Louis, United StatesNo longer taking part
  • Mercy Hospital SouthSt Louis, United StatesNo longer taking part
  • Missouri Baptist Medical CenterSt Louis, United StatesNo longer taking part
  • Siteman Cancer Center at Christian HospitalSt Louis, United StatesNo longer taking part
  • Siteman Cancer Center-South CountySt Louis, United StatesNo longer taking part
  • Washington University School of MedicineSt Louis, United StatesNo longer taking part
  • Saint Helena HospitalSt. Helena, United StatesNo longer taking part
  • Novant Health Cancer Institute - StatesvilleStatesville, United StatesNo longer taking part
  • Marshfield Medical Center-River Region at Stevens PointStevens Point, United StatesNo longer taking part
  • Lakeview HospitalStillwater, United StatesNo longer taking part
  • Cleveland Clinic Cancer Center StrongsvilleStrongsville, United StatesNo longer taking part
  • Saint Vincent Hospital Cancer Center at Sturgeon BaySturgeon Bay, United StatesNo longer taking part
  • Missouri Baptist Sullivan HospitalSullivan, United StatesNo longer taking part
  • Aurora Medical Center in SummitSummit, United StatesNo longer taking part
  • Essentia Health Saint Mary's Hospital - SuperiorSuperior, United StatesNo longer taking part
  • ProMedica Flower HospitalSylvania, United StatesNo longer taking part
  • State University of New York Upstate Medical UniversitySyracuse, United StatesNo longer taking part
  • Northwest Medical Specialties PLLCTacoma, United StatesNo longer taking part
  • MyMichigan Medical Center TawasTawas City, United StatesNo longer taking part
  • Montefiore Medical Center - Moses CampusThe Bronx, United StatesNo longer taking part
  • Montefiore Medical Center-Einstein CampusThe Bronx, United StatesNo longer taking part
  • Montefiore Medical Center-Weiler HospitalThe Bronx, United StatesNo longer taking part
  • Novant Health Cancer Institute - ThomasvilleThomasville, United StatesNo longer taking part
  • ProMedica Toledo Hospital/Russell J Ebeid Children's HospitalToledo, United StatesNo longer taking part
  • Community Medical CenterToms River, United StatesNo longer taking part
  • Dayton Physicians LLC - TroyTroy, United StatesNo longer taking part
  • Upper Valley Medical CenterTroy, United StatesNo longer taking part
  • Saint Luke's Cancer Institute - Twin FallsTwin Falls, United StatesNo longer taking part
  • Vince Lombardi Cancer Clinic-Two RiversTwo Rivers, United StatesNo longer taking part
  • UPMC Cancer Center-UniontownUniontown, United StatesNo longer taking part
  • UPMC Uniontown Hospital Radiation OncologyUniontown, United StatesNo longer taking part
  • PeaceHealth Southwest Medical CenterVancouver, United StatesNo longer taking part
  • Essentia Health Virginia ClinicVirginia, United StatesNo longer taking part
  • Ridgeview Medical CenterWaconia, United StatesNo longer taking part
  • Providence Saint Mary Regional Cancer CenterWalla Walla, United StatesNo longer taking part
  • Henry Ford Health Warren HospitalWarren, United StatesNo longer taking part
  • Saint Joseph Warren HospitalWarren, United StatesNo longer taking part
  • South Pointe HospitalWarrensville Heights, United StatesNo longer taking part
  • Illinois CancerCare - WashingtonWashington, United StatesNo longer taking part
  • UPMC Cancer Center-WashingtonWashington, United StatesNo longer taking part
  • UPMC Washington Hospital Radiation OncologyWashington, United StatesNo longer taking part
  • MedStar Georgetown University HospitalWashington D.C., United StatesNo longer taking part
  • Aurora Cancer Care-Milwaukee WestWauwatosa, United StatesNo longer taking part
  • Aurora West Allis Medical CenterWest Allis, United StatesNo longer taking part
  • Saint Mary's Oncology/Hematology Associates of West BranchWest Branch, United StatesNo longer taking part
  • University of Cincinnati Cancer Center-West ChesterWest Chester, United StatesNo longer taking part
  • Mercy Medical Center-West LakesWest Des Moines, United StatesNo longer taking part
  • UPMC West Mifflin-Cancer Center JeffersonWest Mifflin, United StatesNo longer taking part
  • Reading HospitalWest Reading, United StatesNo longer taking part
  • Marshfield Medical Center - WestonWeston, United StatesNo longer taking part
  • Wexford Health and Wellness PavilionWexford, United StatesNo longer taking part
  • Presbyterian Intercommunity HospitalWhittier, United StatesNo longer taking part
  • Rice Memorial HospitalWillmar, United StatesNo longer taking part
  • Novant Health Forsyth Medical CenterWinston-Salem, United StatesNo longer taking part
  • Minnesota Oncology Hematology PA-WoodburyWoodbury, United StatesNo longer taking part
  • Woodland Memorial HospitalWoodland, United StatesNo longer taking part
  • Cleveland Clinic Wooster Family Health and Surgery CenterWooster, United StatesNo longer taking part
  • North Star Lodge Cancer Center at Yakima Valley Memorial HospitalYakima, United StatesNo longer taking part
  • UPMC MemorialYork, United StatesNo longer taking part
  • Saint Elizabeth Youngstown HospitalYoungstown, United StatesNo longer taking part
  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, United StatesNo longer taking part

Trial details

Who runs it
National Cancer Institute (NCI)
Trial code
NCT03604991
Record updated
2 November 2026
Original description
This phase II/III trial studies the usefulness of treatment with nivolumab and ipilimumab in addition to standard of care chemotherapy and radiation therapy in patients with esophageal and gastroesophageal junction adenocarcinoma who are undergoing surgery. Immunotherapy with antibodies, such as nivolumab and ipilimumab, may remove the brake on the body's immune system and may interfere with the ability of tumor cells to grow and spread. Chemotherapy and radiation therapy may reduce the tumor size and the amount of normal tissue that needs to be removed during surgery. A combined treatment with nivolumab and ipilimumab, chemotherapy, and radiation therapy might be more effective in patients with esophageal and gastroesophageal junction adenocarcinoma who are undergoing surgery.Read full original descriptionShow less

A Phase II/III Study of Peri-Operative Nivolumab and Ipilimumab in Patients With Locoregional Esophageal and Gastroesophageal Junction Adenocarcinoma

This phase II/III trial studies the usefulness of treatment with nivolumab and ipilimumab in addition to standard of care chemotherapy and radiation therapy in patients with esophageal and gastroesophageal junction adenocarcinoma who are undergoing surgery. Immunotherapy with antibodies, such as nivolumab and ipilimumab, may remove the brake on the body's immune system and may interfere with the ability of tumor cells to grow and spread. Chemotherapy and radiation therapy may reduce the tumor size and the amount of normal tissue that needs to be removed during surgery. A combined treatment with nivolumab and ipilimumab, chemotherapy, and radiation therapy might be more effective in patients with esophageal and gastroesophageal junction adenocarcinoma who are undergoing surgery.

Inclusion: STEP 1 RANDOMIZATION: Patients must be age >= 18 years; STEP 1 RANDOMIZATION: Patients must have histologically confirmed T1N1-3M0 or T2-3N0-2M0 esophageal or gastroesophageal junctional adenocarcinoma (Siewert I and II); STEP 1 RANDOMIZATION: Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1; STEP 1 RANDOMIZATION: Patents must be deemed a surgical candidate by a thoracic surgeon, surgical oncologist, or surgeon who is qualified to perform an esophagectomy; STEP 1 RANDOMIZATION: Absolute neutrophil count >= 1,500/mcL (within less than or equal to 14 days prior to randomization); STEP 1 RANDOMIZATION: Platelets >= 100,000/mcL (within less than or equal to 14 days prior to randomization); STEP 1 RANDOMIZATION: Total bilirubin =< institutional upper limit of normal (ULN) (within less than or equal to 14 days prior to randomization); STEP 1 RANDOMIZATION: Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (within less than or equal to 14 days prior to randomization); STEP 1 RANDOMIZATION: Serum creatinine =< 1.5 x institutional ULN (within less than or equal to 14 days prior to randomization); STEP 1 RANDOMIZATION: Hemoglobin (Hgb) >= 9 g/dL (within less than or equal to 14 days prior to randomization); STEP 1 RANDOMIZATION: Leukocytes >= 3,000/mm\^3 (within less than or equal to 14 days prior to randomization); STEP 1 RANDOMIZATION: Patients may not have received prior chemotherapy or radiation therapy for management for this malignancy; STEP 1 RANDOMIZATION: Patients may not have received prior immunotherapy for management of this malignancy or for any other past malignancy; STEP 1 RANDOMIZATION: Patients must have no contraindication to receiving either carboplatin or paclitaxel chemotherapy; STEP 1 RANDOMIZATION: Patients must have no contraindication to receiving radiation therapy; STEP 1 RANDOMIZATION: Patients with active autoimmune disease or history of autoimmune disease that might recur, which may affect vital organ function or require immune suppressive treatment including systemic corticosteroids, must be excluded. These include but are not limited to patients with a history of immune related neurologic disease, multiple sclerosis, autoimmune (demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as systemic lupus erythematosus (SLE), connective tissue disease, scleroderma, inflammatory bowel disease (IBD), Crohn's, ulcerative colitis, hepatitis; and patients with a history of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, or phospholipid syndrome must be excluded because of the risk of recurrence or exacerbation of disease. Patients with vitiligo, endocrine deficiencies including thyroiditis managed with replacement hormones including physiologic corticosteroids are eligible. Patients with rheumatoid arthritis and other arthropathies, Sjogren's syndrome and psoriasis controlled with topical medication and patients with positive serology, such as antinuclear antibodies (ANA), anti-thyroid antibodies must be evaluated for the presence of target organ involvement and potential need for systemic treatment but should otherwise be eligible; STEP 1 RANDOMIZATION: Patients are permitted to enroll if they have vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger (precipitating event); STEP 1 RANDOMIZATION: Patient must NOT have previous or concurrent malignancy. Exceptions are made for patients who meet any of the following conditions:; Non-melanoma skin cancer, in situ cervical cancer, superficial bladder cancer, or breast cancer in situ OR; Prior malignancy completely excised or removed and patient has been continuously disease free for > 5 years OR; Date of last evidence of disease; STEP 1 RANDOMIZATION: Patients must not have a condition requiring systemic treatment with either corticosteroids (> 10 mg/day prednisone equivalents) or other immunosuppressive medications within 14 days of study drug administration. Inhaled or topical steroids and adrenal replacement doses =< 10 mg/day prednisone equivalents are permitted in the absence of active autoimmune disease; STEP 1 RANDOMIZATION: Patients must have adequate cardiac function including electrocardiogram (EKG) and echocardiogram for any patient with a history of congestive heart failure (CHF) or at risk because of underlying cardiovascular disease or exposure to cardiotoxic drugs; STEP 1 RANDOMIZATION: For patients with evidence of uncontrolled CHF, myocardial infarction (MI), cardiomyopathy, or myositis, require a cardiac evaluation and clearance including lab tests and cardiology consultation (EKG, creatinine phosphokinase [CPK], troponin, and echocardiogram); STEP 1 RANDOMIZATION: Patients must not have a positive test result for hepatitis B virus surface antigen (HBV sAg) or hepatitis C virus ribonucleic acid (HCV RNA) indicating acute or chronic infection. Testing should be conducted to determine eligibility; STEP 1 RANDOMIZATION: Patients with a known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) must have no detectable viral load on a stable anti-viral regimen; STEP 1 RANDOMIZATION: Patients must not be receiving any other investigational agents; STEP 1 RANDOMIZATION: Patients with an uncontrolled intercurrent illness such as ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia or psychiatric illness/social situations that would limit compliance with study requirements will be excluded; STEP 1 RANDOMIZATION: Patients must not be pregnant or breast-feeding due to potential harm to an unborn fetus and possible risk for adverse events in nursing infants from carboplatin, paclitaxel, ipilimumab or nivolumab; All patients of childbearing potential must have a blood test or urine study done within 2 weeks prior to randomization to rule out pregnancy. Those enrolled on Arm B with nivolumab must agree to have a pregnancy test (minimum sensitivity 25 IU/L or equivalent units of human chorionic gonadotropin [HCG]) within 24 hours of starting nivolumab to rule out pregnancy; A patient of childbearing potential is defined as anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months); STEP 1 RANDOMIZATION: Patients of childbearing potential must not expect to conceive children by either abstaining from sexual intercourse for the duration of their participation in the study or by agreeing to use both double barrier contraception and birth control pills or implants for at least one month prior to the start of the study drug and continuing for 5 months after the last dose of study drug. Investigators shall counsel patients of childbearing potential on the importance of pregnancy prevention and the implications of an unexpected pregnancy; STEP 2 RANDOMIZATION: Patient registration must not exceed 12 weeks from time of esophagectomy; STEP 2 RANDOMIZATION: Patients must have a post-operative ECOG performance status of 0-2; STEP 2 RANDOMIZATION: Absolute neutrophil count >= 1,500/mcL (within less than or equal to 14 days prior to randomization); STEP 2 RANDOMIZATION: Platelets >= 100,000/mcL (within less than or equal to 14 days prior to randomization); STEP 2 RANDOMIZATION: Total bilirubin =< institutional upper limit of normal (ULN) (within less than or equal to 14 days prior to randomization); STEP 2 RANDOMIZATION: AST (SGOT)/ ALT (SGPT) =< 2.5 x institutional ULN (within less than or equal to 14 days prior to randomization); STEP 2 RANDOMIZATION: Serum creatinine =< 1.5 x institutional ULN (within less than or equal to 14 days prior to randomization); STEP 2 RANDOMIZATION: Patients must be disease free following esophagectomy as is demonstrated by having no evidence of disease on a post-surgical CT scan. Patients must also have a negative surgical margin (R0 resection); STEP 2 RANDOMIZATION: Patients must not have an active, known or suspected autoimmune disease or a condition requiring treatment with steroids or immunosuppressive agents. Patients are permitted to enroll if they have vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger; STEP 2 RANDOMIZATION: Patients must not have a condition requiring systemic treatment with either corticosteroids (> 10 mg/day prednisone equivalents) or other immunosuppressive medications with 14 days of study drug administration. Inhaled or topical steroids and adrenal replacement doses > 10 mg/day prednisone equivalents are permitted in the absence of active autoimmune disease; STEP 2 RANDOMIZATION: Patients must not be receiving any other investigational agents; STEP 2 RANDOMIZATION: Patients with an uncontrolled intercurrent illness such as ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia or psychiatric illness/social situations that would limit compliance with study requirements will be excluded; STEP 2 RANDOMIZATION: Patients must not be pregnant or breast-feeding due to potential harm to an unborn fetus and possible risks for adverse events in nursing infants from nivolumab or ipilimumab; All patients of childbearing potential must have a blood test or urine study done (minimum sensitivity 25 IU/L or equivalent units of HCG) within 2 weeks prior to randomization to rule out pregnancy. All patients must also agree to have a pregnancy test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 24 hours of starting nivolumab to rule out pregnancy. Those enrolled on Arm D with ipilimumab must agree to have pregnancy tests within 72 hours of each ipilimumab administration to rule out pregnancy; STEP 2 RANDOMIZATION: Patients of childbearing potential must not expect to conceive children by either abstaining from sexual intercourse for the duration of their participation in the study or by agreeing to use both double barrier contraception and birth control pills or implants for at least one month prior to the start of the study drug and continuing for 5 months after the last dose of study drug. Investigators shall counsel patients of childbearing potential on the importance of pregnancy prevention and the implications of an unexpected pregnancy.

ClinicalTrials.gov NCT03604991