Taking peopleNo phase

A Prospective Cohort Study of Patients Suffering From Hand Osteoarthritis Symptoms

Key facts

Who runs it: University Hospital, Montpellier
Where: France1 site in 1 countryChoose a country to see its sites
Trial code: NCT03650673
Status: Recruiting
People taking part: 150 people, planned
Started: 15 Jul 2019
Expected to end: 31 Oct 2028
Type of study: Interventional
Treatments tested: Identification of subgroups of patients with early AD with risk of progression
Record updated: 30 September 2025

Who can take part

Age: 18 years to 60 years
Sex: Women and men
Healthy volunteers: Cannot take part

The registry criteria, word for word

Show all 13 criteriaShow less

Who can take part

Early digital osteoarthritis must combine the clinical AND radiological definition; Clinical definition:; At least one of the following 4 criteria: Pain or stiffness or swelling or deformity of a digital joint (IPP and / or IPD) A breach of at least one PPI and / or IPD Age under 60 at the time of the first symptoms Clinical symptoms have been changing for less than 3 years; Radiographic definition:; The presence of the achievement of at least one PPI and / or IPD. Presence of at least two of the following three criteria: pinching, marginal subchondral condensation, marginal osteophyte Erosion on radiography is not an exclusion criteria
Consent form signed

Who cannot take part

Presence of advanced radiographic osteoarthritis based in Kellgreen Lawrence score (=4) in one joint among the 10 previous sites
Being in exclusion period determined by another previous study
patients suffering from metabolic diseasis such as gout, hemochromatosis, Wilson's disease; or from congenital disease such as displasie, osteogenesis,
patients suffering from rheumatoid arthritis, rheumatoid psoriasis or any other inflammatory rheumatism
Not able to provide a sample of blood for any reasons
MRI contraindication
Subject non affiliated to social insurance
Pregnant or lactating women
Vulnerable people based in L1121-5 article of CSP
Elderly subject or protected subjects disabled to give their consent
Subjects private of freedom by court or administrative order

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 60 years old?

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

The late-stage forms of degenerative osteoarthritis (OA) are very debilitating and less affordable to therapy. The main objective is to identify early onset symptoms of hand OA patients through imaging techniques (such as ultrasound and MRI). Our primary endpoint is to specify patients with high risk of radiological profression (X-ray).

The group in the trial

Diagnostic Test: Identification of subgroups of patients withOther group
Treatment: Identification of subgroups of patients with early AD with risk of progression