Brain-Signal Device Tested for Movement and Speech Control
Tests a brain-signal device to control movement and speech in adults with serious neurological disorders.
Plain-language title generated from the registry record
Registry title: ECoG BMI for Motor and Speech Control
Key facts
- Where
- San Francisco, United StatesSee the site
Where in United States
- University of California San FranciscoSan Francisco, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Karunesh Ganguly
- Trial code
- NCT03698149
- Record updated
- 5 May 2026
- Original description
Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.Read full original descriptionShow less
A High-Performance ECoG-based Neural Interface for Communication and Neuroprosthetic Control
Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.
Inclusion: Age \> 21; Limited ability to use upper limbs, based on neurological examination, due to stroke, amyotrophic lateral sclerosis (ALS), multiple sclerosis, cervical spinal cord injury, brainstem stroke, muscular dystrophy, myopathy or severe neuropathy; Disability, defined by a 4 or greater score on the Modified Rankin Scale, must be severe enough to cause loss of independence and inability to perform activities of daily living; If stroke or spinal cord injury, at least 1 year has passed since onset of symptoms; Must live within a two-hour drive of UCSF.
Exclusion: Any prior intracranial surgery; Dementia, based on history, physical exam, and MMSE; Active depression (BDI \> 20) or other psychiatric illness (active general anxiety disorder, schizophrenia, bipolar disorder, obsessive-compulsive disorder (OCD), or personality disorders (e.g. multiple personality disorder, borderline personality disorder, etc.); History of suicide attempt or suicidal ideation; History of substance abuse; Co-morbidities including ongoing anticoagulation, uncontrolled hypertension, cancer, or major organ system failure; History of seizures; Has an active infection; Requires diathermy, electroconvulsive therapy (ECT), or transcranial magnetic stimulation (TMS) to treat a chronic condition; Has an implanted electronic device such as a neurostimulator, cardiac pacemaker/defibrillator or medication pump, or presence of any head or neck metallic foreign bodies; Allergies or known hypersensitivity to materials in the Blackrock NeuroPort Array (i.e. silicone, titanium) or the PMT Subdural Cortical Electrode (silicone, platinum iridium, nichrome); Pregnancy or breastfeeding; Inability to understand and/or read English; Inability to give consent; Inability to comply with study follow-up visits; Immunocompromised; Has a CSF drainage system or an active CSF leak.