Imaging heart rhythm circuits before and after ablation in scar-related ventricular tachycardia
Tests heart electrical imaging to map rapid heartbeat circuits in people with heart scar.
Plain-language title generated from the registry record
Registry title: Peri-Procedural Transmural Electrophysiological (EP) Imaging of Scar-Related Ventricular Tachycardia
Key facts
- Where
- Halifax, CanadaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with repeated fast heartbeats from the heart's lower chambers (ventricular tachycardia), who are referred for catheter ablation and already have an implanted defibrillator (ICD).
- Age
- 18 Years to 85 Years
- Sex
- All sexes can join.
- Disease stage
- One or more episodes of sustained monomorphic ventricular tachycardia (VT). Referred for catheter ablation.
- Earlier treatment
- Must already have an implanted ICD.
Main reasons for not taking part
- eGFR (kidney function) less than 30
- Life expectancy less than 6 months, or listed for heart transplantation
- Pregnant
- On IV inotropic agents, or NYHA functional class IV
- Unwilling or unable to have both a cardiac MRI scan and a cardiac CT scan
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT03713866, who can take part
Where in Canada
- QEII HSCHalifax, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- John Sapp
- Trial code
- NCT03713866
- Record updated
- 17 March 2026
- Original description
Ventricular tachycardia (VT) contributes to over 350,000 sudden deaths each year in the US. Malignant VTs involve an electrical "short circuit" in the heart, formed by narrow channels of surviving tissue inside myocardial scar. An important treatment is to use catheter ablation to "block" the channel that forms the circuit. Effective ablation requires imaging guidance to visualize the VT circuit relative to scar structures in 3D. Unfortunately, with conventional catheter mapping, up to 90% of the VT circuits are too short-lived to be mapped. For the 10% "mappable" VTs, their data are only available during ablation and limited to one ventricular surface. This inadequacy of functional VT data largely limits the knowledge about scar-related VT and ablation strategies, and reduces the ability of clinicians to identify ablation targets and assess ablation outcome.Read full original descriptionShow less
Peri-Procedural Transmural Electrophysiological Imaging of Scar-Related Ventricular Tachycardia
Ventricular tachycardia (VT) contributes to over 350,000 sudden deaths each year in the US. Malignant VTs involve an electrical "short circuit" in the heart, formed by narrow channels of surviving tissue inside myocardial scar. An important treatment is to use catheter ablation to "block" the channel that forms the circuit. Effective ablation requires imaging guidance to visualize the VT circuit relative to scar structures in 3D. Unfortunately, with conventional catheter mapping, up to 90% of the VT circuits are too short-lived to be mapped. For the 10% "mappable" VTs, their data are only available during ablation and limited to one ventricular surface. This inadequacy of functional VT data largely limits the knowledge about scar-related VT and ablation strategies, and reduces the ability of clinicians to identify ablation targets and assess ablation outcome.
The central hypothesis of this proposal is that functional VT data, integrated with CT or MRI scar data in 3D, can improve VT ablation efficacy with pre-procedural identification of ablation targets and post-procedural mechanistic elucidation of ablation failure. This research builds on the rapidly increasing clinical interest in electrocardiographic imaging (ECGi), an emerging technique that obtains cardiac electrical activity through inverse reconstructions from ECGs. The specific objective is to push the boundary of ECGi to provide - as a conjunction to intra-procedural catheter mapping - pre-ablation and post-ablation imaging of functional VT circuits integrated with 3D scar structure.
Inclusion: One or more episodes of sustained monomorphic VT; Referred for catheter ablation; Previously implanted ICD; Signed the patient informed consent form; Able and willing to comply with all pre-, post-, and follow-up testing and requirements.
Exclusion: Have a life expectancy less than 6 months or are listed for heart transplantation at time of inclusion; New York Heart Association (NYHA) functional class IV; Had ST wave elevation myocardial infarction within < 1 month; Unwilling or unable to undergo cardiac MRI scan AND unwilling or unable to undergo cardiac CT scan (e.g. contrast allergy); Have estimated Glomerular Filtration Ratio (eGFR) less than 30; Are pregnant; Are on IV inotropic agents; Have any contraindication to catheter ablation (including but not limited to mechanical prosthetic aortic and mitral valves, known protruding Left Ventricular (LV) thrombus.