Comparison of Effectiveness Between PL and PRP on Knee Osteoarthritis: a Prospective,Randomized,Placebo-controlled Trial
Key facts
- Phase
- Phase 4
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 80 years old?
Source: NCT03734900, who can take part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- National Taiwan University Hospital
- Trial code
- NCT03734900
- Record updated
- 21 September 2026
- Original description
This study will focus on grade I to III knee osteoarthritis by randomized controlled trials which comparing the effectiveness between placebo, autologous platelet rich plasma and autologous platelet lysate injections.Read full original descriptionShow less
Comparison of Effectiveness Between Platelet Lysate and Platelet-rich Plasma on Knee Osteoarthritis: a Prospective, Randomized, Placebo-controlled Trial
This study will focus on grade I to III knee osteoarthritis by randomized controlled trials which comparing the effectiveness between placebo, autologous platelet rich plasma and autologous platelet lysate injections.
Inclusion: 50 to 80 years old; Study Subjects must be willing to sign Informed Consent to participate in the study; In the past month, at least seven consecutive days in the squat, standing, walking or going up and down the stairs, the most serious degree of visual analogy of the knee pain (Visual Analogue Scale) is greater than or equal to 40 (the most pain is 100, not painful is 0); Morning joint stiffness is less than 30 minutes; X-ray：Grade 1-3 radiographic OA as defined by the K-L classification.
Exclusion: Taking NSAIDs or steroids (including oral and injection) within one week; Using anticoagulant drugs for a long time; tumors, infections or the trauma before the same site; Platelet count is less than 150,000 / UL, or coagulation disorders, prothrombin time (PT value) is less than 11 seconds or greater than 16 seconds; Leukemia, sepsis, platelet dysfunction or other blood related diseases; Knee instability; The knee joint is obviously deformed (> 5 degree valgus or varus deviation on X-ray); Clinical diagnosed as Pes tendinitis, Chondromalacia; Pregnancy.