TerminatedPhase 2
Targeted Treatment for ALK Positive Patients Who Have Previously Been Treated for Non-squamous Non-small Cell Lung Cancer
Reason given: Inadequate accrual rate
Key facts
- Where
- ‘Aiea, Aitkin, Allentown, Altoona, Ames, Anaconda, Anaheim, Ann Arbor, Antioch, Arroyo Grande, Ashland, Atlanta, Aurora, Aventura, Baker City, Baldwin Park, Ballwin, Baltimore, Bangor, Bardstown, Beavercreek, Bellflower, Belpre, Bemidji, Bethel Park, Bethlehem, Billings, Bismarck, Bloomington, Boardman, Boca Raton, Boise, Bonne Terre, Boone, Boston, Bozeman, Brainerd, Branson, Brewer, Brighton, Brownstown, Bryan, Bryn Mawr, Burien, Burnsville, Caldwell, Cambridge, Canton, Cape Girardeau, Carbondale, Caro, Carterville, Carthage, Centerville, Centralia, Chadds Ford, Charlottesville, Chattanooga, Chelsea, Chicago, Chillicothe, Cincinnati, City of Saint Peters, Clarkston, Cleveland, Clinton Township, Clive, Cody, Coeur d'Alene, Colorado Springs, Columbus, Coon Rapids, Corbin, Council Bluffs, Creston, Creve Coeur, Dallas, Danville, Dayton, Dearborn, Decatur, Deer River, Delaware, Denver, Des Moines, Detroit, Detroit Lakes, Dixon, Dublin, Duluth, Durango, East China Township, East Stroudsburg, Eau Claire, Edina, Effingham, El Segundo, Emmett, Enumclaw, Eureka, Evanston, Fargo, Farmington, Farmington Hills, Federal Way, Fergus Falls, Findlay, Flint, Fontana, Fort Dodge, Fort Lauderdale, Fort Smith, Fosston, Franklin, Fremont, Fresno, Fridley, Gahanna, Galesburg, Glenview, Golden, Goodyear, Grand Island, Great Falls, Greenville, Gresham, Grosse Pointe Woods, Grove City, Harbor City, Harrisburg, Hazleton, Helena, Hibbing, Highland Park, Hixson, Honolulu, Hot Springs, Houston, Indianapolis, Irvine, Jackson, Jacksonville, Jamestown, Jefferson, Jefferson City, Johns Creek, Joplin, Kalispell, Kearney, Kenansville, Kettering, Kewanee, Key West, Kinston, La Jolla, Lakewood, Lakewood Rch, Lancaster, Lansing, Lawrenceville, Lewes, Lewisburg, Lewistown, Lexington, Lihue, Lincoln, Littleton, Livonia, Loma Linda, London, Longmont, Los Angeles, Louisville, Macomb, Madison Heights, Mansfield, Maple Grove, Maplewood, Marietta, Marion, Marlette, Marshalltown, Marshfield, Mattoon, McKeesport, Media, Memphis, Meridian, Millville, Milwaukee, Minneapolis, Minocqua, Missoula, Modesto, Monticello, Mount Vernon, Mukwonago, N. Huntingdon, Nampa, New Richmond, New Ulm, New York, Newark, Newnan, Novi, O'Fallon, Oakland, Oconomowoc, Oklahoma City, Omaha, Ontario, Ooltewah, Ottawa, Palm Beach Gardens, Panorama City, Paoli, Papillion, Park Rapids, Parker, Pekin, Peoria, Peru, Philadelphia, Phoenix, Pittsburgh, Plantation, Pontiac, Portland, Portsmouth, Post Falls, Pottsville, Poulsbo, Princeton, Pueblo, Rancho Cordova, Redwood City, Rehoboth Beach, Rice Lake, Richlands, Richmond, Riverside, Robbinsdale, Rochester, Rochester Hills, Rohnert Park, Rolla, Roseville, Sacramento, Saginaw, Saint Joseph, Saint Louis Park, Saint Paul, Sainte Genevieve, Salt Lake City, San Diego, San Francisco, San Jose, San Leandro, San Luis Obispo, San Marcos, San Rafael, Sandpoint, Sandstone, Santa Clara, Santa Maria, Santa Rosa, Scottsdale, Scranton, Seaford, Selinsgrove, Shakopee, Shelby, Shepherdsville, Sheridan, Silverdale, Sioux Falls, Snellville, South San Francisco, Southhaven, Springfield, St Louis, State College, Sterling Heights, Stevens Point, Stillwater, Stockton, Sullivan, Sunset Hills, Swansea, Tacoma, Tawas City, Thief River Falls, Thornton, Troy, Tulsa, Urbana, Vacaville, Vallejo, Vancouver, Virginia, Waconia, Walnut Creek, Warren, Washington, Washington D.C., Waukesha, West Bloomfield, West Branch, West Chester, West Des Moines, West Palm Beach, Westerville, Weston, Wilkes-Barre, Willmar, Wilmington, Woodbury, Woodland Hills, Worthington, Wynnewood, Wyoming, Yorkville, Youngstown, Ypsilanti, and Zanesville, United StatesSee the 491 sites
- Phase
- Phase 2
Where in United States
- Hawaii Cancer Care - Westridge‘Aiea, United StatesNo longer taking part
- Pali Momi Medical Center‘Aiea, United StatesNo longer taking part
- Queen's Cancer Center - Pearlridge‘Aiea, United StatesNo longer taking part
- The Cancer Center of Hawaii-Pali Momi‘Aiea, United StatesNo longer taking part
- Riverwood Healthcare CenterAitkin, United StatesNo longer taking part
- Lehigh Valley Hospital-Cedar CrestAllentown, United StatesNo longer taking part
- UPMC AltoonaAltoona, United StatesNo longer taking part
- Mary Greeley Medical CenterAmes, United StatesNo longer taking part
- McFarland Clinic - AmesAmes, United StatesNo longer taking part
- Community Hospital of AnacondaAnaconda, United StatesNo longer taking part
- Kaiser Permanente-AnaheimAnaheim, United StatesNo longer taking part
- Trinity Health Saint Joseph Mercy Hospital Ann ArborAnn Arbor, United StatesNo longer taking part
- Kaiser Permanente-Deer Valley Medical CenterAntioch, United StatesNo longer taking part
- Mission Hope Medical Oncology - Arroyo GrandeArroyo Grande, United StatesNo longer taking part
- Duluth Clinic AshlandAshland, United StatesNo longer taking part
- Northwest Wisconsin Cancer CenterAshland, United StatesNo longer taking part
- Emory Saint Joseph's HospitalAtlanta, United StatesNo longer taking part
- Emory University Hospital MidtownAtlanta, United StatesNo longer taking part
- Emory University Hospital/Winship Cancer InstituteAtlanta, United StatesNo longer taking part
- Grady Health SystemAtlanta, United StatesNo longer taking part
- Northside HospitalAtlanta, United StatesNo longer taking part
- Rush-Copley Medical CenterAurora, United StatesNo longer taking part
- UCHealth University of Colorado HospitalAurora, United StatesNo longer taking part
- GenesisCare USA - Aventura FPAventura, United StatesNo longer taking part
- Saint Alphonsus Cancer Care Center-Baker CityBaker City, United StatesNo longer taking part
- Kaiser Permanente-Baldwin ParkBaldwin Park, United StatesNo longer taking part
- Mercy Oncology and Hematology - Clayton-ClarksonBallwin, United StatesNo longer taking part
- Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimore, United StatesNo longer taking part
- Saint Agnes HospitalBaltimore, United StatesNo longer taking part
- Eastern Maine Medical CenterBangor, United StatesNo longer taking part
- Flaget Memorial HospitalBardstown, United StatesNo longer taking part
- Indu and Raj Soin Medical CenterBeavercreek, United StatesNo longer taking part
- Kaiser Permanente-BellflowerBellflower, United StatesNo longer taking part
- Strecker Cancer Center-BelpreBelpre, United StatesNo longer taking part
- Sanford Joe Lueken Cancer CenterBemidji, United StatesNo longer taking part
- UPMC Cancer Center-Bethel ParkBethel Park, United StatesNo longer taking part
- Lehigh Valley Hospital - MuhlenbergBethlehem, United StatesNo longer taking part
- Billings Clinic Cancer CenterBillings, United StatesNo longer taking part
- Sanford Bismarck Medical CenterBismarck, United StatesNo longer taking part
- Illinois CancerCare-BloomingtonBloomington, United StatesNo longer taking part
- Saint Elizabeth Boardman HospitalBoardman, United StatesNo longer taking part
- GenesisCare USA - Boca Ration FP06Boca Raton, United StatesNo longer taking part
- GenesisCare USA - Boca Raton FP02Boca Raton, United StatesNo longer taking part
- Saint Alphonsus Cancer Care Center-BoiseBoise, United StatesNo longer taking part
- Parkland Health Center-Bonne TerreBonne Terre, United StatesNo longer taking part
- McFarland Clinic - BooneBoone, United StatesNo longer taking part
- Massachusetts General Hospital Cancer CenterBoston, United StatesNo longer taking part
- Bozeman Health Deaconess HospitalBozeman, United StatesNo longer taking part
- Essentia Health Saint Joseph's Medical CenterBrainerd, United StatesNo longer taking part
- Cox Cancer Center BransonBranson, United StatesNo longer taking part
- Lafayette Family Cancer Center-EMMCBrewer, United StatesNo longer taking part
- Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, United StatesNo longer taking part
- Trinity Health Medical Center - BrightonBrighton, United StatesNo longer taking part
- Henry Ford Cancer Institute-DownriverBrownstown, United StatesNo longer taking part
- Saint Joseph Regional Cancer CenterBryan, United StatesNo longer taking part
- Bryn Mawr HospitalBryn Mawr, United StatesNo longer taking part
- Highline Medical Center-Main CampusBurien, United StatesNo longer taking part
- Fairview Ridges HospitalBurnsville, United StatesNo longer taking part
- Minnesota Oncology - BurnsvilleBurnsville, United StatesNo longer taking part
- Saint Alphonsus Cancer Care Center-CaldwellCaldwell, United StatesNo longer taking part
- Cambridge Medical CenterCambridge, United StatesNo longer taking part
- Illinois CancerCare-CantonCanton, United StatesNo longer taking part
- Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, United StatesNo longer taking part
- Trinity Health Medical Center - CantonCanton, United StatesNo longer taking part
- Mercy Cancer Center - Cape GirardeauCape Girardeau, United StatesNo longer taking part
- Saint Francis Medical CenterCape Girardeau, United StatesNo longer taking part
- Memorial Hospital of CarbondaleCarbondale, United StatesNo longer taking part
- Caro Cancer CenterCaro, United StatesNo longer taking part
- SIH Cancer InstituteCarterville, United StatesNo longer taking part
- Illinois CancerCare-CarthageCarthage, United StatesNo longer taking part
- Dayton Physicians LLC-Miami Valley SouthCenterville, United StatesNo longer taking part
- Miami Valley Hospital SouthCenterville, United StatesNo longer taking part
- Centralia Oncology ClinicCentralia, United StatesNo longer taking part
- Christiana Care Health System-Concord Health CenterChadds Ford, United StatesNo longer taking part
- University of Virginia Cancer CenterCharlottesville, United StatesNo longer taking part
- Memorial HospitalChattanooga, United StatesNo longer taking part
- Chelsea HospitalChelsea, United StatesNo longer taking part
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, United StatesNo longer taking part
- University of IllinoisChicago, United StatesNo longer taking part
- Adena Regional Medical CenterChillicothe, United StatesNo longer taking part
- Bethesda North HospitalCincinnati, United StatesNo longer taking part
- Good Samaritan Hospital - CincinnatiCincinnati, United StatesNo longer taking part
- Oncology Hematology Care Inc-KenwoodCincinnati, United StatesNo longer taking part
- TriHealth Cancer Institute-AndersonCincinnati, United StatesNo longer taking part
- TriHealth Cancer Institute-WestsideCincinnati, United StatesNo longer taking part
- University of Cincinnati Cancer Center-UC Medical CenterCincinnati, United StatesNo longer taking part
- Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, United StatesNo longer taking part
- Hematology Oncology Consultants-ClarkstonClarkston, United StatesNo longer taking part
- Michigan Healthcare Professionals ClarkstonClarkston, United StatesNo longer taking part
- Newland Medical Associates-ClarkstonClarkston, United StatesNo longer taking part
- Cleveland Clinic FoundationCleveland, United StatesNo longer taking part
- Henry Ford Macomb Hospital-Clinton TownshipClinton Township, United StatesNo longer taking part
- Mercy Cancer Center-West LakesClive, United StatesNo longer taking part
- UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, United StatesNo longer taking part
- Billings Clinic-CodyCody, United StatesNo longer taking part
- Kootenai Health - Coeur d'AleneCoeur d'Alene, United StatesNo longer taking part
- Memorial Hospital NorthColorado Springs, United StatesNo longer taking part
- Penrose-Saint Francis HealthcareColorado Springs, United StatesNo longer taking part
- Rocky Mountain Cancer Centers-PenroseColorado Springs, United StatesNo longer taking part
- UCHealth Memorial Hospital CentralColorado Springs, United StatesNo longer taking part
- Columbus Oncology and Hematology Associates IncColumbus, United StatesNo longer taking part
- Doctors HospitalColumbus, United StatesNo longer taking part
- Grant Medical CenterColumbus, United StatesNo longer taking part
- Mount Carmel East HospitalColumbus, United StatesNo longer taking part
- Mount Carmel Health Center WestColumbus, United StatesNo longer taking part
- Ohio State University Comprehensive Cancer CenterColumbus, United StatesNo longer taking part
- Riverside Methodist HospitalColumbus, United StatesNo longer taking part
- The Mark H Zangmeister CenterColumbus, United StatesNo longer taking part
- Mercy HospitalCoon Rapids, United StatesNo longer taking part
- Commonwealth Cancer Center-CorbinCorbin, United StatesNo longer taking part
- Alegent Health Mercy HospitalCouncil Bluffs, United StatesNo longer taking part
- Greater Regional Medical CenterCreston, United StatesNo longer taking part
- Siteman Cancer Center at West County HospitalCreve Coeur, United StatesNo longer taking part
- Parkland Memorial HospitalDallas, United StatesNo longer taking part
- UT Southwestern/Simmons Cancer Center-DallasDallas, United StatesNo longer taking part
- Carle at The RiverfrontDanville, United StatesNo longer taking part
- Geisinger Medical CenterDanville, United StatesNo longer taking part
- Dayton Physician LLC - EnglewoodDayton, United StatesNo longer taking part
- Good Samaritan Hospital - DaytonDayton, United StatesNo longer taking part
- Miami Valley HospitalDayton, United StatesNo longer taking part
- Miami Valley Hospital NorthDayton, United StatesNo longer taking part
- Henry Ford Medical Center-FairlaneDearborn, United StatesNo longer taking part
- Cancer Care Specialists of Illinois - DecaturDecatur, United StatesNo longer taking part
- Decatur Memorial HospitalDecatur, United StatesNo longer taking part
- Essentia Health - Deer River ClinicDeer River, United StatesNo longer taking part
- Delaware Health Center-Grady Cancer CenterDelaware, United StatesNo longer taking part
- Grady Memorial HospitalDelaware, United StatesNo longer taking part
- AdventHealth PorterDenver, United StatesNo longer taking part
- Mercy Medical Center - Des MoinesDes Moines, United StatesNo longer taking part
- UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, United StatesNo longer taking part
- Henry Ford Health Saint John HospitalDetroit, United StatesNo longer taking part
- Henry Ford HospitalDetroit, United StatesNo longer taking part
- Essentia Health Saint Mary's - Detroit Lakes ClinicDetroit Lakes, United StatesNo longer taking part
- Illinois CancerCare-DixonDixon, United StatesNo longer taking part
- Dublin Methodist HospitalDublin, United StatesNo longer taking part
- Kaiser Permanente DublinDublin, United StatesNo longer taking part
- Essentia Health Cancer CenterDuluth, United StatesNo longer taking part
- Essentia Health Saint Mary's Medical CenterDuluth, United StatesNo longer taking part
- Miller-Dwan HospitalDuluth, United StatesNo longer taking part
- Northside Hospital - DuluthDuluth, United StatesNo longer taking part
- CommonSpirit Cancer Center MercyDurango, United StatesNo longer taking part
- Mercy Medical CenterDurango, United StatesNo longer taking part
- Henry Ford River District HospitalEast China Township, United StatesNo longer taking part
- Pocono Medical CenterEast Stroudsburg, United StatesNo longer taking part
- Marshfield Medical Center-EC Cancer CenterEau Claire, United StatesNo longer taking part
- Fairview Southdale HospitalEdina, United StatesNo longer taking part
- Carle Physician Group-EffinghamEffingham, United StatesNo longer taking part
- Crossroads Cancer CenterEffingham, United StatesNo longer taking part
- 21st Century Oncology - El SegundoEl Segundo, United StatesNo longer taking part
- Walter Knox Memorial HospitalEmmett, United StatesNo longer taking part
- Saint Elizabeth HospitalEnumclaw, United StatesNo longer taking part
- Illinois CancerCare-EurekaEureka, United StatesNo longer taking part
- NorthShore University HealthSystem-Evanston HospitalEvanston, United StatesNo longer taking part
- Essentia Health Cancer Center-South University ClinicFargo, United StatesNo longer taking part
- Sanford Broadway Medical CenterFargo, United StatesNo longer taking part
- Sanford Medical Center FargoFargo, United StatesNo longer taking part
- Sanford Roger Maris Cancer CenterFargo, United StatesNo longer taking part
- Sanford South University Medical CenterFargo, United StatesNo longer taking part
- Southpointe-Sanford Medical Center FargoFargo, United StatesNo longer taking part
- Parkland Health Center - FarmingtonFarmington, United StatesNo longer taking part
- Michigan Healthcare Professionals FarmingtonFarmington Hills, United StatesNo longer taking part
- Saint Francis HospitalFederal Way, United StatesNo longer taking part
- Lake Region Healthcare Corporation-Cancer CareFergus Falls, United StatesNo longer taking part
- Armes Family Cancer CenterFindlay, United StatesNo longer taking part
- Blanchard Valley HospitalFindlay, United StatesNo longer taking part
- Orion Cancer CareFindlay, United StatesNo longer taking part
- Cancer Hematology Centers - FlintFlint, United StatesNo longer taking part
- Genesee Hematology Oncology PCFlint, United StatesNo longer taking part
- Genesys Hurley Cancer InstituteFlint, United StatesNo longer taking part
- Hurley Medical CenterFlint, United StatesNo longer taking part
- Kaiser Permanente-FontanaFontana, United StatesNo longer taking part
- McFarland Clinic - Trinity Cancer CenterFort Dodge, United StatesNo longer taking part
- Holy Cross HospitalFort Lauderdale, United StatesNo longer taking part
- Mercy Hospital Fort SmithFort Smith, United StatesNo longer taking part
- Essentia Health - FosstonFosston, United StatesNo longer taking part
- Atrium Medical Center-Middletown Regional HospitalFranklin, United StatesNo longer taking part
- Dayton Physicians LLC-AtriumFranklin, United StatesNo longer taking part
- Kaiser Permanente-FremontFremont, United StatesNo longer taking part
- Fresno Cancer CenterFresno, United StatesNo longer taking part
- Kaiser Permanente-FresnoFresno, United StatesNo longer taking part
- Unity HospitalFridley, United StatesNo longer taking part
- Central Ohio Breast and Endocrine SurgeryGahanna, United StatesNo longer taking part
- Illinois CancerCare-GalesburgGalesburg, United StatesNo longer taking part
- Western Illinois Cancer Treatment CenterGalesburg, United StatesNo longer taking part
- NorthShore University HealthSystem-Glenbrook HospitalGlenview, United StatesNo longer taking part
- Mountain Blue Cancer Care CenterGolden, United StatesNo longer taking part
- CTCA at Western Regional Medical CenterGoodyear, United StatesNo longer taking part
- Nebraska Cancer Specialists/Oncology Hematology West PCGrand Island, United StatesNo longer taking part
- Benefis Sletten Cancer InstituteGreat Falls, United StatesNo longer taking part
- Great Falls ClinicGreat Falls, United StatesNo longer taking part
- Dayton Physicians LLC-WayneGreenville, United StatesNo longer taking part
- Wayne HospitalGreenville, United StatesNo longer taking part
- Legacy Mount Hood Medical CenterGresham, United StatesNo longer taking part
- Henry Ford Saint John Hospital - AcademicGrosse Pointe Woods, United StatesNo longer taking part
- Henry Ford Saint John Hospital - BreastGrosse Pointe Woods, United StatesNo longer taking part
- Henry Ford Saint John Hospital - Van ElslanderGrosse Pointe Woods, United StatesNo longer taking part
- Mount Carmel Grove City HospitalGrove City, United StatesNo longer taking part
- Kaiser Permanente South BayHarbor City, United StatesNo longer taking part
- UPMC Pinnacle Cancer Center/Community Osteopathic CampusHarrisburg, United StatesNo longer taking part
- Geisinger Medical Center-Cancer Center HazletonHazleton, United StatesNo longer taking part
- Lehigh Valley Hospital-HazletonHazleton, United StatesNo longer taking part
- Saint Peter's Community HospitalHelena, United StatesNo longer taking part
- Essentia Health Hibbing ClinicHibbing, United StatesNo longer taking part
- NorthShore University HealthSystem-Highland Park HospitalHighland Park, United StatesNo longer taking part
- Pulmonary Medicine Center of Chattanooga-HixsonHixson, United StatesNo longer taking part
- Hawaii Cancer Care Inc - Waterfront PlazaHonolulu, United StatesNo longer taking part
- Hawaii Cancer Care Inc-LilihaHonolulu, United StatesNo longer taking part
- Island UrologyHonolulu, United StatesNo longer taking part
- Kaiser Permanente Moanalua Medical CenterHonolulu, United StatesNo longer taking part
- Kapiolani Medical Center for Women and ChildrenHonolulu, United StatesNo longer taking part
- Kuakini Medical CenterHonolulu, United StatesNo longer taking part
- Queen's Cancer Cenrer - POB IHonolulu, United StatesNo longer taking part
- Queen's Cancer Center - KuakiniHonolulu, United StatesNo longer taking part
- Queen's Medical CenterHonolulu, United StatesNo longer taking part
- Straub Clinic and HospitalHonolulu, United StatesNo longer taking part
- The Cancer Center of Hawaii-LilihaHonolulu, United StatesNo longer taking part
- University of Hawaii Cancer CenterHonolulu, United StatesNo longer taking part
- CHI Saint Vincent Cancer Center Hot SpringsHot Springs, United StatesNo longer taking part
- M D Anderson Cancer CenterHouston, United StatesNo longer taking part
- Indiana University/Melvin and Bren Simon Cancer CenterIndianapolis, United StatesNo longer taking part
- Kaiser Permanente-IrvineIrvine, United StatesNo longer taking part
- Allegiance HealthJackson, United StatesNo longer taking part
- Mayo Clinic in FloridaJacksonville, United StatesNo longer taking part
- Essentia Health - Jamestown ClinicJamestown, United StatesNo longer taking part
- McFarland Clinic - JeffersonJefferson, United StatesNo longer taking part
- MU Health Care Goldschmidt Cancer CenterJefferson City, United StatesNo longer taking part
- Emory Johns Creek HospitalJohns Creek, United StatesNo longer taking part
- Freeman Health SystemJoplin, United StatesNo longer taking part
- Mercy Hospital JoplinJoplin, United StatesNo longer taking part
- Logan Health Medical CenterKalispell, United StatesNo longer taking part
- CHI Health Good SamaritanKearney, United StatesNo longer taking part
- Fred and Pamela Buffett Cancer Center - KearneyKearney, United StatesNo longer taking part
- ECU Health Oncology KenansvilleKenansville, United StatesNo longer taking part
- First Dayton Cancer CareKettering, United StatesNo longer taking part
- Greater Dayton Cancer CenterKettering, United StatesNo longer taking part
- Kettering Medical CenterKettering, United StatesNo longer taking part
- Illinois CancerCare-Kewanee ClinicKewanee, United StatesNo longer taking part
- GenesisCare USA - Key WestKey West, United StatesNo longer taking part
- ECU Health Oncology KinstonKinston, United StatesNo longer taking part
- UC San Diego Moores Cancer CenterLa Jolla, United StatesNo longer taking part
- Rocky Mountain Cancer Centers-LakewoodLakewood, United StatesNo longer taking part
- Saint Anthony HospitalLakewood, United StatesNo longer taking part
- Saint Clare HospitalLakewood, United StatesNo longer taking part
- GenesisCare USA - Lakewood RanchLakewood Rch, United StatesNo longer taking part
- Fairfield Medical CenterLancaster, United StatesNo longer taking part
- University of Michigan Health - Sparrow LansingLansing, United StatesNo longer taking part
- Northside Hospital - GwinnettLawrenceville, United StatesNo longer taking part
- Beebe Medical CenterLewes, United StatesNo longer taking part
- Geisinger Medical Oncology-LewisburgLewisburg, United StatesNo longer taking part
- Lewistown HospitalLewistown, United StatesNo longer taking part
- Saint Joseph Hospital EastLexington, United StatesNo longer taking part
- Saint Joseph Radiation Oncology Resource CenterLexington, United StatesNo longer taking part
- Wilcox Memorial Hospital and Kauai Medical ClinicLihue, United StatesNo longer taking part
- Saint Elizabeth Regional Medical CenterLincoln, United StatesNo longer taking part
- AdventHealth LittletonLittleton, United StatesNo longer taking part
- Hope Cancer ClinicLivonia, United StatesNo longer taking part
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, United StatesNo longer taking part
- Loma Linda University Medical CenterLoma Linda, United StatesNo longer taking part
- Saint Joseph LondonLondon, United StatesNo longer taking part
- Longmont United HospitalLongmont, United StatesNo longer taking part
- Rocky Mountain Cancer Centers-LongmontLongmont, United StatesNo longer taking part
- Kaiser Permanente Los Angeles Medical CenterLos Angeles, United StatesNo longer taking part
- Kaiser Permanente West Los AngelesLos Angeles, United StatesNo longer taking part
- Jewish HospitalLouisville, United StatesNo longer taking part
- Saints Mary and Elizabeth HospitalLouisville, United StatesNo longer taking part
- UofL Health Medical Center NortheastLouisville, United StatesNo longer taking part
- Henry Ford Saint John Hospital - Macomb MedicalMacomb, United StatesNo longer taking part
- Henry Ford Warren Hospital - Breast MacombMacomb, United StatesNo longer taking part
- Illinois CancerCare-MacombMacomb, United StatesNo longer taking part
- Michigan Healthcare Professionals MacombMacomb, United StatesNo longer taking part
- Michigan Healthcare Professionals Madison HeightsMadison Heights, United StatesNo longer taking part
- OhioHealth Mansfield HospitalMansfield, United StatesNo longer taking part
- Fairview Clinics and Surgery Center Maple GroveMaple Grove, United StatesNo longer taking part
- Minnesota Oncology Hematology PA-MaplewoodMaplewood, United StatesNo longer taking part
- Saint John's Hospital - HealtheastMaplewood, United StatesNo longer taking part
- Marietta Memorial HospitalMarietta, United StatesNo longer taking part
- OhioHealth Marion General HospitalMarion, United StatesNo longer taking part
- Saint Mary's Oncology/Hematology Associates of MarletteMarlette, United StatesNo longer taking part
- McFarland Clinic - MarshalltownMarshalltown, United StatesNo longer taking part
- Marshfield Medical Center-MarshfieldMarshfield, United StatesNo longer taking part
- Carle Physician Group-Mattoon/CharlestonMattoon, United StatesNo longer taking part
- UPMC Cancer Center at UPMC McKeesportMcKeesport, United StatesNo longer taking part
- Riddle Memorial HospitalMedia, United StatesNo longer taking part
- Baptist Memorial Hospital and Cancer Center-MemphisMemphis, United StatesNo longer taking part
- Idaho Urologic Institute-MeridianMeridian, United StatesNo longer taking part
- Beebe South Coastal Health CampusMillville, United StatesNo longer taking part
- Medical College of WisconsinMilwaukee, United StatesNo longer taking part
- Abbott-Northwestern HospitalMinneapolis, United StatesNo longer taking part
- Health Partners IncMinneapolis, United StatesNo longer taking part
- Hennepin County Medical CenterMinneapolis, United StatesNo longer taking part
- Marshfield Medical Center - MinocquaMinocqua, United StatesNo longer taking part
- Community Medical CenterMissoula, United StatesNo longer taking part
- Kaiser Permanente-ModestoModesto, United StatesNo longer taking part
- Monticello Cancer CenterMonticello, United StatesNo longer taking part
- Knox Community HospitalMount Vernon, United StatesNo longer taking part
- SSM Health Good SamaritanMount Vernon, United StatesNo longer taking part
- ProHealth D N Greenwald CenterMukwonago, United StatesNo longer taking part
- Arnold Palmer Cancer Center Medical Oncology NorwinN. Huntingdon, United StatesNo longer taking part
- Saint Alphonsus Cancer Care Center-NampaNampa, United StatesNo longer taking part
- Cancer Center of Western WisconsinNew Richmond, United StatesNo longer taking part
- New Ulm Medical CenterNew Ulm, United StatesNo longer taking part
- Mount Sinai ChelseaNew York, United StatesNo longer taking part
- Mount Sinai HospitalNew York, United StatesNo longer taking part
- Christiana Care Health System-Christiana HospitalNewark, United StatesNo longer taking part
- Delaware Clinical and Laboratory Physicians PANewark, United StatesNo longer taking part
- Helen F Graham Cancer CenterNewark, United StatesNo longer taking part
- Licking Memorial HospitalNewark, United StatesNo longer taking part
- Medical Oncology Hematology Consultants PANewark, United StatesNo longer taking part
- Newark Radiation OncologyNewark, United StatesNo longer taking part
- CTCA at Southeastern Regional Medical CenterNewnan, United StatesNo longer taking part
- Henry Ford Medical Center-ColumbusNovi, United StatesNo longer taking part
- Cancer Care Center of O'FallonO'Fallon, United StatesNo longer taking part
- Kaiser Permanente Oakland-BroadwayOakland, United StatesNo longer taking part
- Kaiser Permanente-OaklandOakland, United StatesNo longer taking part
- ProHealth Oconomowoc Memorial HospitalOconomowoc, United StatesNo longer taking part
- Mercy Hospital Oklahoma CityOklahoma City, United StatesNo longer taking part
- University of Oklahoma Health Sciences CenterOklahoma City, United StatesNo longer taking part
- Alegent Health Bergan Mercy Medical CenterOmaha, United StatesNo longer taking part
- Alegent Health Immanuel Medical CenterOmaha, United StatesNo longer taking part
- Alegent Health Lakeside HospitalOmaha, United StatesNo longer taking part
- Creighton University Medical CenterOmaha, United StatesNo longer taking part
- Hematology and Oncology Consultants PCOmaha, United StatesNo longer taking part
- Nebraska Methodist HospitalOmaha, United StatesNo longer taking part
- Kaiser Permanente-OntarioOntario, United StatesNo longer taking part
- Saint Alphonsus Cancer Care Center-OntarioOntario, United StatesNo longer taking part
- Memorial GYN PlusOoltewah, United StatesNo longer taking part
- Illinois CancerCare-Ottawa ClinicOttawa, United StatesNo longer taking part
- GenesisCare USA - Palm Beach GardensPalm Beach Gardens, United StatesNo longer taking part
- Kaiser Permanente - Panorama CityPanorama City, United StatesNo longer taking part
- Paoli Memorial HospitalPaoli, United StatesNo longer taking part
- Midlands Community HospitalPapillion, United StatesNo longer taking part
- Essentia Health - Park RapidsPark Rapids, United StatesNo longer taking part
- AdventHealth ParkerParker, United StatesNo longer taking part
- Rocky Mountain Cancer Centers-ParkerParker, United StatesNo longer taking part
- Illinois CancerCare-PekinPekin, United StatesNo longer taking part
- Illinois CancerCare-PeoriaPeoria, United StatesNo longer taking part
- Methodist Medical Center of IllinoisPeoria, United StatesNo longer taking part
- Illinois CancerCare-PeruPeru, United StatesNo longer taking part
- Valley Radiation OncologyPeru, United StatesNo longer taking part
- Eastern Regional Medical CenterPhiladelphia, United StatesNo longer taking part
- Fox Chase Cancer CenterPhiladelphia, United StatesNo longer taking part
- Mayo Clinic Hospital in ArizonaPhoenix, United StatesNo longer taking part
- Oncology Hematology AssociationPittsburgh, United StatesNo longer taking part
- Saint Clair HospitalPittsburgh, United StatesNo longer taking part
- University of Pittsburgh Cancer Institute (UPCI)Pittsburgh, United StatesNo longer taking part
- UPMC-Mercy HospitalPittsburgh, United StatesNo longer taking part
- UPMC-Passavant HospitalPittsburgh, United StatesNo longer taking part
- GenesisCare USA - PlantationPlantation, United StatesNo longer taking part
- Hope Cancer CenterPontiac, United StatesNo longer taking part
- Michigan Healthcare Professionals PontiacPontiac, United StatesNo longer taking part
- Newland Medical Associates-PontiacPontiac, United StatesNo longer taking part
- Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, United StatesNo longer taking part
- Legacy Good Samaritan Hospital and Medical CenterPortland, United StatesNo longer taking part
- Southern Ohio Medical CenterPortsmouth, United StatesNo longer taking part
- Kootenai Clinic Cancer Services - Post FallsPost Falls, United StatesNo longer taking part
- Geisinger Cancer Services-PottsvillePottsville, United StatesNo longer taking part
- Harrison HealthPartners Hematology and Oncology-PoulsboPoulsbo, United StatesNo longer taking part
- Fairview Northland Medical CenterPrinceton, United StatesNo longer taking part
- Illinois CancerCare-PrincetonPrinceton, United StatesNo longer taking part
- Rocky Mountain Cancer Centers - PuebloPueblo, United StatesNo longer taking part
- Saint Mary Corwin Medical CenterPueblo, United StatesNo longer taking part
- Kaiser Permanente-Rancho Cordova Cancer CenterRancho Cordova, United StatesNo longer taking part
- Kaiser Permanente-Redwood CityRedwood City, United StatesNo longer taking part
- Beebe Health CampusRehoboth Beach, United StatesNo longer taking part
- Marshfield Medical Center-Rice LakeRice Lake, United StatesNo longer taking part
- ECU Health Oncology RichlandsRichlands, United StatesNo longer taking part
- Kaiser Permanente-RichmondRichmond, United StatesNo longer taking part
- Reid HealthRichmond, United StatesNo longer taking part
- Kaiser Permanente-RiversideRiverside, United StatesNo longer taking part
- North Memorial Medical Health CenterRobbinsdale, United StatesNo longer taking part
- Mayo Clinic in RochesterRochester, United StatesNo longer taking part
- University of RochesterRochester, United StatesNo longer taking part
- Henry Ford Rochester HospitalRochester Hills, United StatesNo longer taking part
- Rohnert Park Cancer CenterRohnert Park, United StatesNo longer taking part
- Mercy Clinic-Rolla-Cancer and HematologyRolla, United StatesNo longer taking part
- Phelps Health Delbert Day Cancer InstituteRolla, United StatesNo longer taking part
- Kaiser Permanente-RosevilleRoseville, United StatesNo longer taking part
- The Permanente Medical Group-Roseville Radiation OncologyRoseville, United StatesNo longer taking part
- Kaiser Permanente Downtown CommonsSacramento, United StatesNo longer taking part
- Kaiser Permanente Sacramento Medical CenterSacramento, United StatesNo longer taking part
- Kaiser Permanente-South SacramentoSacramento, United StatesNo longer taking part
- South Sacramento Cancer CenterSacramento, United StatesNo longer taking part
- MyMichigan Medical Center SaginawSaginaw, United StatesNo longer taking part
- Oncology Hematology Associates of Saginaw Valley PCSaginaw, United StatesNo longer taking part
- Heartland Regional Medical CenterSaint Joseph, United StatesNo longer taking part
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, United StatesNo longer taking part
- Regions HospitalSaint Paul, United StatesNo longer taking part
- United HospitalSaint Paul, United StatesNo longer taking part
- Sainte Genevieve County Memorial HospitalSainte Genevieve, United StatesNo longer taking part
- Huntsman Cancer Institute/University of UtahSalt Lake City, United StatesNo longer taking part
- Kaiser Permanente-San Diego MissionSan Diego, United StatesNo longer taking part
- Kaiser Permanente-San Diego ZionSan Diego, United StatesNo longer taking part
- Kaiser Permanente-San FranciscoSan Francisco, United StatesNo longer taking part
- Kaiser Permanente-Santa Teresa-San JoseSan Jose, United StatesNo longer taking part
- Kaiser Permanente San LeandroSan Leandro, United StatesNo longer taking part
- Pacific Central Coast Health Center-San Luis ObispoSan Luis Obispo, United StatesNo longer taking part
- Kaiser Permanente-San MarcosSan Marcos, United StatesNo longer taking part
- Kaiser Permanente-San RafaelSan Rafael, United StatesNo longer taking part
- Kaiser San Rafael-GallinasSan Rafael, United StatesNo longer taking part
- Kootenai Clinic Cancer Services - SandpointSandpoint, United StatesNo longer taking part
- Essentia Health SandstoneSandstone, United StatesNo longer taking part
- Kaiser Permanente Medical Center - Santa ClaraSanta Clara, United StatesNo longer taking part
- Mission Hope Medical Oncology - Santa MariaSanta Maria, United StatesNo longer taking part
- Kaiser Permanente-Santa RosaSanta Rosa, United StatesNo longer taking part
- Mayo Clinic in ArizonaScottsdale, United StatesNo longer taking part
- Community Medical CenterScranton, United StatesNo longer taking part
- TidalHealth Nanticoke / Allen Cancer CenterSeaford, United StatesNo longer taking part
- Geisinger Medical Oncology-SelinsgroveSelinsgrove, United StatesNo longer taking part
- Saint Francis Regional Medical CenterShakopee, United StatesNo longer taking part
- Henry Ford Macomb Health Center - Shelby TownshipShelby, United StatesNo longer taking part
- Jewish Hospital Medical Center SouthShepherdsville, United StatesNo longer taking part
- Welch Cancer CenterSheridan, United StatesNo longer taking part
- Saint Michael Cancer CenterSilverdale, United StatesNo longer taking part
- Sanford Cancer Center Oncology ClinicSioux Falls, United StatesNo longer taking part
- Sanford USD Medical Center - Sioux FallsSioux Falls, United StatesNo longer taking part
- Suburban Hematology Oncology Associates - SnellvilleSnellville, United StatesNo longer taking part
- Kaiser Permanente Cancer Treatment CenterSouth San Francisco, United StatesNo longer taking part
- Kaiser Permanente-South San FranciscoSouth San Francisco, United StatesNo longer taking part
- Baptist Memorial Hospital and Cancer Center-DesotoSouthhaven, United StatesNo longer taking part
- CoxHealth South HospitalSpringfield, United StatesNo longer taking part
- Mercy Hospital SpringfieldSpringfield, United StatesNo longer taking part
- Mercy Medical CenterSpringfield, United StatesNo longer taking part
- Southern Illinois University School of MedicineSpringfield, United StatesNo longer taking part
- Springfield ClinicSpringfield, United StatesNo longer taking part
- Springfield Memorial HospitalSpringfield, United StatesNo longer taking part
- Springfield Regional Cancer CenterSpringfield, United StatesNo longer taking part
- Springfield Regional Medical CenterSpringfield, United StatesNo longer taking part
- Mercy Hospital Saint LouisSt Louis, United StatesNo longer taking part
- Mercy Hospital SouthSt Louis, United StatesNo longer taking part
- Mercy Infusion Center - ChippewaSt Louis, United StatesNo longer taking part
- Missouri Baptist Medical CenterSt Louis, United StatesNo longer taking part
- Siteman Cancer Center at Christian HospitalSt Louis, United StatesNo longer taking part
- Siteman Cancer Center-South CountySt Louis, United StatesNo longer taking part
- Washington University School of MedicineSt Louis, United StatesNo longer taking part
- Geisinger Medical GroupState College, United StatesNo longer taking part
- Bhadresh Nayak MD PC-Sterling HeightsSterling Heights, United StatesNo longer taking part
- Marshfield Medical Center-River Region at Stevens PointStevens Point, United StatesNo longer taking part
- Lakeview HospitalStillwater, United StatesNo longer taking part
- Kaiser Permanente-StocktonStockton, United StatesNo longer taking part
- Missouri Baptist Sullivan HospitalSullivan, United StatesNo longer taking part
- BJC Outpatient Center at Sunset HillsSunset Hills, United StatesNo longer taking part
- Southwest Illinois Health Services LLPSwansea, United StatesNo longer taking part
- Franciscan Research Center-Northwest Medical PlazaTacoma, United StatesNo longer taking part
- Northwest Medical Specialties PLLCTacoma, United StatesNo longer taking part
- MyMichigan Medical Center TawasTawas City, United StatesNo longer taking part
- Sanford Thief River Falls Medical CenterThief River Falls, United StatesNo longer taking part
- Rocky Mountain Cancer Centers-ThorntonThornton, United StatesNo longer taking part
- Dayton Physicians LLC - TroyTroy, United StatesNo longer taking part
- Michigan Healthcare Professionals TroyTroy, United StatesNo longer taking part
- Upper Valley Medical CenterTroy, United StatesNo longer taking part
- Cancer Treatment Centers of AmericaTulsa, United StatesNo longer taking part
- Oklahoma Cancer Specialists and Research Institute-TulsaTulsa, United StatesNo longer taking part
- Carle Cancer CenterUrbana, United StatesNo longer taking part
- The Carle Foundation HospitalUrbana, United StatesNo longer taking part
- Kaiser Permanente Medical Center-VacavilleVacaville, United StatesNo longer taking part
- Kaiser Permanente-VallejoVallejo, United StatesNo longer taking part
- Legacy Salmon Creek HospitalVancouver, United StatesNo longer taking part
- Essentia Health Virginia ClinicVirginia, United StatesNo longer taking part
- Ridgeview Medical CenterWaconia, United StatesNo longer taking part
- Kaiser Permanente-Walnut CreekWalnut Creek, United StatesNo longer taking part
- Advanced Breast Care Center PLLCWarren, United StatesNo longer taking part
- Henry Ford Health Warren HospitalWarren, United StatesNo longer taking part
- Henry Ford Madison Heights Hospital - BreastWarren, United StatesNo longer taking part
- Henry Ford Warren Hospital - GLCMSWarren, United StatesNo longer taking part
- Macomb Hematology Oncology PCWarren, United StatesNo longer taking part
- Saint Joseph Warren HospitalWarren, United StatesNo longer taking part
- Mercy Hospital WashingtonWashington, United StatesNo longer taking part
- UPMC Cancer Center-WashingtonWashington, United StatesNo longer taking part
- Sibley Memorial HospitalWashington D.C., United StatesNo longer taking part
- ProHealth Waukesha Memorial HospitalWaukesha, United StatesNo longer taking part
- UW Cancer Center at ProHealth CareWaukesha, United StatesNo longer taking part
- Henry Ford West Bloomfield HospitalWest Bloomfield, United StatesNo longer taking part
- Saint Mary's Oncology/Hematology Associates of West BranchWest Branch, United StatesNo longer taking part
- University of Cincinnati Cancer Center-West ChesterWest Chester, United StatesNo longer taking part
- Mercy Medical Center-West LakesWest Des Moines, United StatesNo longer taking part
- Good Samaritan Medical CenterWest Palm Beach, United StatesNo longer taking part
- Saint Ann's HospitalWesterville, United StatesNo longer taking part
- Marshfield Medical Center - WestonWeston, United StatesNo longer taking part
- Geisinger Wyoming Valley/Henry Cancer CenterWilkes-Barre, United StatesNo longer taking part
- Rice Memorial HospitalWillmar, United StatesNo longer taking part
- Christiana Care Health System-Wilmington HospitalWilmington, United StatesNo longer taking part
- Minnesota Oncology Hematology PA-WoodburyWoodbury, United StatesNo longer taking part
- Kaiser Permanente-Woodland HillsWoodland Hills, United StatesNo longer taking part
- Sanford Cancer Center WorthingtonWorthington, United StatesNo longer taking part
- Lankenau Medical CenterWynnewood, United StatesNo longer taking part
- Fairview Lakes Medical CenterWyoming, United StatesNo longer taking part
- Rush-Copley Healthcare CenterYorkville, United StatesNo longer taking part
- Saint Elizabeth Youngstown HospitalYoungstown, United StatesNo longer taking part
- Huron Gastroenterology PCYpsilanti, United StatesNo longer taking part
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, United StatesNo longer taking part
- Genesis Healthcare System Cancer Care CenterZanesville, United StatesNo longer taking part
Trial details
- Who runs it
- National Cancer Institute (NCI)
- Trial code
- NCT03737994
- Record updated
- 23 April 2026
- Original description
This National Cancer Institute (NCI)-NRG ALK Protocol phase II trial studies how well a combination of different biomarker/ALK inhibitors work in treating patients with stage IV ALK positive non-squamous non-small cell lung cancer. Lorlatinib, ceritinib, alectinib, brigatinib, ensartinib, and crizotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as pemetrexed, cisplatin, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether a combination of biomarker/ALK inhibitors or chemotherapy may work better in treating patients with ALK positive non-squamous non-small cell lung cancer.Read full original descriptionShow less
A Biomarker-Driven Protocol for Previously Treated ALK-Positive Non-Squamous NSCLC Patients: The NCI-NRG ALK Protocol
This National Cancer Institute (NCI)-NRG ALK Protocol phase II trial studies how well a combination of different biomarker/ALK inhibitors work in treating patients with stage IV ALK positive non-squamous non-small cell lung cancer. Lorlatinib, ceritinib, alectinib, brigatinib, ensartinib, and crizotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as pemetrexed, cisplatin, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether a combination of biomarker/ALK inhibitors or chemotherapy may work better in treating patients with ALK positive non-squamous non-small cell lung cancer.
Inclusion: PRIOR TO STEP 1 REGISTRATION; Patients must have histologically or cytologically confirmed stage IV ALK-positive non-squamous non-small cell lung carcinoma (NSCLC) (includes M1a, M1b, M1c stage disease, American Joint Committee on Cancer [AJCC] 8th edition). ALK rearrangement must have been demonstrated by a Food and Drug Administration (FDA) approved assay (Vysis fluorescence in situ hybridization [FISH] or Ventana immunohistochemistry [IHC]) or by next generation sequencing (NGS); Patient must be willing and able to undergo a fresh biopsy or if patient has a biopsy after progression on current tyrosine-kinase inhibitor (TKI) within 3 months of study enrollment (and has continued TKI for clinical benefit per treating physician) this tissue may be used. Must have sufficient tissue; Patient must have progressive disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 after one second generation ALK inhibitor, including LDK378 (ceritinib), alectinib, ensartinib, and brigatinib (may not have received more than one second-generation ALK inhibitor). Patient may have received prior crizotinib; however, the second generation ALK inhibitor received must be the last treatment given prior to study enrollment; Prior lorlatinib (third-generation ALK inhibitor) is not allowed; Prior chemotherapy is not allowed except for one prior cycle received at the time of original diagnosis of metastatic NSCLC with no evidence of disease progression following the cycle. NOTE: prior adjuvant or neoadjuvant chemotherapy is allowed if last dose was received more than 12 months prior to enrollment; The patient or a legally authorized representative must provide study-specific informed consent prior to Step 1 Registration; PRIOR TO STEP 2 REGISTRATION; Absolute neutrophil count (ANC) >= 1500 cells/mm\^3 (within 28 days prior to step 2 registration); Platelets >= 100,000 cells/mm\^3 (within 28 days prior to step 2 registration); Estimated creatinine clearance >= 60 mL/min by the Cockcroft Gault formula (within 28 days prior to step 2 registration); Total bilirubin =< 1.5 x upper limit of normal (ULN) (except for patients with documented Gilbert's syndrome) (within 28 days prior to step 2 registration); Aspartate aminotransferase (AST) =< 2.5 x ULN; =< 5 x ULN if liver metastases are present (within 28 days prior to step 2 registration); Alanine aminotransferase (ALT) =< 2.5 x ULN; =< 5 x ULN if liver metastases are present (within 28 days prior to step 2 registration); Patients with asymptomatic treated or untreated brain metastases are eligible. Treated brain metastases are eligible as long as patients have measurable disease outside the brain according to RECIST 1.1. Patients must be on a stable or decreasing dose of steroids for at least 7 days prior to step 2 registration. Anticonvulsants are allowed as long as the patient is neurologically stable and not deteriorating; Patients enrolled with asymptomatic brain metastases (mets) must have at least one measurable target extracranial lesion according to RECIST 1.1; Eastern Cooperative Oncology Group (ECOG) performance status 0-2; Acute effects of any prior therapy resolved to baseline severity or to Common Terminology Criteria for Adverse Events (CTCAE) grade =< 1 (except for alopecia, hearing loss); Not taking any medications that may interact with selected study medication based on stratification; Patients must be able to take oral medications (i.e. swallow whole tablets/capsules); All females of childbearing potential must have a blood test or urine study within 14 days prior to Step 2 Registration to rule out pregnancy. A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria:; Has not undergone a hysterectomy or bilateral oophorectomy; or; Has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months); Women must not be pregnant or breast-feeding due to potential harm to the fetus or infant from ALK inhibitors and the unknown risk. Women of childbearing potential and sexually active males must agree to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study.
Exclusion: Palliative RT (< 10 fractions) must have been completed at least 48 hours prior to study entry. Stereotactic or small field brain irradiation must have completed at least 1 week prior to study entry. Whole brain RT or other palliative RT must have been completed at least 2 weeks prior to study entry; Prior dose of next generation ALK inhibitor (LDK378 [ceritinib], alectinib, ensartinib, lorlatinib) within 5 days prior to step 2 registration. Prior dose of brigatinib within 7 days prior to step 2 registration; History of interstitial lung disease or interstitial fibrosis, including a history of pneumonitis, obliterative bronchiolitis, pulmonary fibrosis. Patients with a history of prior radiation pneumonitis are not excluded; Other concomitant serious illness or organ system dysfunction that in the opinion of the investigator would either compromise patient safety or interfere with the evaluation of the safety of the study drug; Patients must not plan to receive any other investigational agents during the course of therapy; Patients with active malignancy other than ALK-positive non-squamous NSCLC within the last 2 years are excluded (note: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, papillary thyroid cancer treated with curative intent, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for 2 years are eligible); No chemotherapy and/or immunotherapy allowed after step 1 registration; Major surgery within 2 weeks of study entry. Minor surgical procedures (e.g., port insertion, pleurex catheter placement) are allowed and all wounds must not show signs of infection or draining; Active inflammatory gastrointestinal disease (such as Crohns, ulcerative colitis), chronic diarrhea, symptomatic diverticular disease, or any gastrointestinal disease that would affect the absorption of oral medications or increase the risk of toxicity; Clinically significant cardiovascular abnormalities, as determined by the treating/registering physician, such as uncontrolled hypertension, congestive heart failure New York Heart Association (NYHA) classification of 3, unstable angina or poorly controlled arrhythmia, or myocardial infarction within 6 months; Active and clinically significant bacterial, fungal, or viral infection; Patients with active or chronic pancreatitis based on lipase elevation, symptoms, and radiographic findings.