Tests a heart procedure called ischemic postconditioning in heart attack patients
Tests ischemic postconditioning, a brief blood-flow procedure, in adults having a STEMI heart attack.
Plain-language title generated from the registry record
Registry title: Ischemic Postconditioning in STEMI Patients Treated With Primary PCI
Key facts
- Where
- Copenhagen, DenmarkSee the site
Where in Denmark
- The Heart Center, Rigshospitalet, University of CopenhagenCopenhagen, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Copenhagen University Hospital, Rigshospitalet
- Trial code
- NCT03787745
- Record updated
- 30 March 2026
- Original description
In a prospective, randomized clinical trial the iPOST2 trial will determine whether ischemic postconditioning reduces reperfusion injury and this will translate into improved clinical outcome of heart failure and death for STEMI patients who present with TIMI0-1 undergoing primary PCIRead full original descriptionShow less
The Effect of Ischemic Postconditioning in Patients With STEMI Undergoing Primary PCI (DANAMI4-iPOST2)
In a prospective, randomized clinical trial the iPOST2 trial will determine whether ischemic postconditioning reduces reperfusion injury and this will translate into improved clinical outcome of heart failure and death for STEMI patients who present with TIMI0-1 undergoing primary PCI
Inclusion: Age ≥18 years; Acute onset of chest pain with < 12 hours duration; STEMI as characterized by 2 mm ST elevation in 2 or more V1 through V4 leads or presumed new left bundle branch block with minimum of 1 mm concordant ST elevation or 1 mV ST-segment elevation in the limb lead (II, III and aVF, I, aVL) and V4-V6 or ST depression in 2 or more V1 through V4 leads indicating posterior AMI; TIMI flow 0-1 in infarct related artery.
Exclusion: Potential pregnancy; Refusal to participate; OHCA without subsequent consciousness despite ROSC; Thrombectomy considered unavoidable.