Observational database tracking chronic diseases, treatments and outcomes over time
Collects real-world patient records on chronic diseases and their treatments in routine care.
Key facts
- Who runs it
- Epividian
- Where
- Durham, United StatesSee the site
- Trial code
- Registry title
- Observational Pharmaco-Epidemiology Research & Analysis
- Status
- Recruiting
- People taking part
- 2,000,000 people, planned
- Started
- 1 Dec 2013
- Expected to end
- Nov 2035
- Type of study
- Observational
- Treatments tested
- Non-interventional (observational only)
- Record updated
- 11 September 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for patients treated at the practices that take part in the study, whose treatment is recorded in the practice's electronic health record system. It only collects routine care data.
- Age
- From 0 years, no upper limit stated.
- Sex
- All sexes can join.
Main reasons for not taking part
- Patients who opt out of OPERA
The registry criteria, word for word
Show all 3 criteriaShow less
Who can take part
- Patients who are treated in the practices who enroll and participate in the study
- Patients whose treatment is documented in the practice's electronic health record system
Who cannot take part
- Patients who opt out of OPERA
Where in United States
- EpividianDurham, United StatesContact: Rodney MoodTaking people
About the trial
What the trial wants to find out
Greater advances are needed in two separate but related areas in healthcare: 1) the Clinical Decision Support Systems that complement the EHR use in support of routine patient care, population management and disease management; and 2) the use of the point-of-care observational data from the provider-patient encounter that support realworld medical research and healthcare quality measure assessment. Real-world evaluations of treatments of chronic diseases in the context of comorbid conditions and special populations (minorities, women, mentally ill, and those with addiction) are limited. The purpose of the OPERA database is to help address this unmet need in clinical research.
Treatments tested
- Non-interventional (observational only)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- OPERA Longitudinal Observational Database in the Study of Chronic Diseases, Treatments and Outcomes
- Plain-language title
- Observational database tracking chronic diseases, treatments and outcomes over timeGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 11 September 2026