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Taking people in United StatesNo phase

Observational database tracking chronic diseases, treatments and outcomes over time

Collects real-world patient records on chronic diseases and their treatments in routine care.

Key facts

Who runs it
Epividian
Where
Durham, United StatesSee the site
Trial code
Registry title
Observational Pharmaco-Epidemiology Research & Analysis
Status
Recruiting
People taking part
2,000,000 people, planned
Started
1 Dec 2013
Expected to end
Nov 2035
Type of study
Observational
Treatments tested
  • Non-interventional (observational only)
Record updated
11 September 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for patients treated at the practices that take part in the study, whose treatment is recorded in the practice's electronic health record system. It only collects routine care data.

Age
From 0 years, no upper limit stated.
Sex
All sexes can join.

Main reasons for not taking part

  • Patients who opt out of OPERA

The registry criteria, word for word

Show all 3 criteriaShow less

Who can take part

  • Patients who are treated in the practices who enroll and participate in the study
  • Patients whose treatment is documented in the practice's electronic health record system

Who cannot take part

  • Patients who opt out of OPERA

Where in United States

  • EpividianDurham, United StatesContact: Rodney MoodTaking people

About the trial

What the trial wants to find out

Greater advances are needed in two separate but related areas in healthcare: 1) the Clinical Decision Support Systems that complement the EHR use in support of routine patient care, population management and disease management; and 2) the use of the point-of-care observational data from the provider-patient encounter that support realworld medical research and healthcare quality measure assessment. Real-world evaluations of treatments of chronic diseases in the context of comorbid conditions and special populations (minorities, women, mentally ill, and those with addiction) are limited. The purpose of the OPERA database is to help address this unmet need in clinical research.

Treatments tested

  • Non-interventional (observational only)

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
OPERA Longitudinal Observational Database in the Study of Chronic Diseases, Treatments and Outcomes
Plain-language title
Observational database tracking chronic diseases, treatments and outcomes over timeGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
11 September 2026