Epinephrine Dose: Optimal Versus Standard Evaluation Trial
Key facts
- Where
- Brampton, London, Oakville, Ottawa, Saskatoon, Thunder Bay, Victoria, Waterloo, and Windsor, CanadaSee the 9 sites
- Phase
- Phase 4
Where in Canada
- Peel Regional Paramedic ServicesBrampton, CanadaContact: Theresa AvesTaking people
- Middlesex-London Paramedic ServiceLondon, CanadaContact: Manya CharetteTaking people
- Halton Region Paramedic ServicesOakville, CanadaContact: Theresa AvesTaking people
- Ottawa Paramedic ServicesOttawa, CanadaContact: Manya CharetteTaking people
- Medavie Health Services WestSaskatoon, CanadaContact: Tracy Wilson, PhDTaking people
- Superior North Emergency Medical ServicesThunder Bay, CanadaContact: Manya CharetteTaking people
- British Columbia Emergency Health Services (BCEHS)Victoria, CanadaContact: Helen ConnollyTaking people
- Region of Waterloo Paramedic ServicesWaterloo, CanadaContact: Kathy Winter, MDTaking people
- Essex-Windsor Emergency Health ServicesWindsor, CanadaContact: Manya CharetteTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Unity Health Toronto
- Trial code
- NCT03826524
- Record updated
- 2 October 2026
- Original description
The objective of this randomized controlled trial is to evaluate whether a low cumulative dose of epinephrine ("low dose") is non-inferior to a standard cumulative dose of epinephrine ("standard dose") with respect to survival to hospital discharge among adults undergoing resuscitation for OHCA due to ventricular fibrillation (VF) or pulseless ventricular tachycardia (pVT).Read full original descriptionShow less
CanROC Epinephrine Dose: Optimal Versus Standard Evaluation Trial (CanROC EpiDOSE Trial)
The objective of this randomized controlled trial is to evaluate whether a low cumulative dose of epinephrine ("low dose") is non-inferior to a standard cumulative dose of epinephrine ("standard dose") with respect to survival to hospital discharge among adults undergoing resuscitation for OHCA due to ventricular fibrillation (VF) or pulseless ventricular tachycardia (pVT).
Inclusion: Out-of-hospital cardiac arrest treated by paramedics AND; Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or confirmed by paramedics or fire services, AND; Established intravenous vascular access.
Exclusion: Initial recorded cardiac rhythm of VF or pulseless VT, or, AED shock on first analysis administered or confirmed by paramedics; Cardiac arrest due to an obvious non-cardiac primary cause (e.g. blunt or penetrating trauma, exsanguination, burns, drug overdose, drowning, anaphylaxis, sudden asphyxiation, etc.); Known allergy or sensitivity to epinephrine; Known or apparent age <18 years; Administration of intramuscular, endotracheal tube, or intraosseous epinephrine; Prisoners or persons in police custody.