NCT03854071Recruiting
Development of Novel Physiological CMR Methods in Health and Disease
Source: ClinicalTrials.gov · Last updated 18 Mar 2026
Brief summary (registry, in English)
Physiological cardiovascular stress test plays a crucial role in the assessment of patients with suspected heart disease. There are several methods of cardiac physiological stress tests and each of them offer varied insight into cardiac physiological adaptation: passive leg raise, intra-venous fluid challenge, pharmacological stressors and physical exercise stress test. Echocardiography, which is the mainstay for the non-invasive rest/stress assessment of the left ventricular (LV) haemodynamics has several limitations. Novel methods of CMR imaging allow to map intra-cardiac flow in three-dimension using novel flow acquisitions. These novel flow acquisitions are called four-dimensional flow CMR, where the fourth dimension is time. Additionally, traditional cine CMR imaging for functional assessment can now be done without breath-holds using advanced acceleration methods, allowing them to be used during exercise. A comprehensive understanding of functional-flow coupling at rest, during increased pre-load (fluid challenge) to the heart or during exercise, is lacking in the literature. There is an important need to validate these novel CMR methods for developing mechanistic insight into physiological cardiac adaptation to increased pre-load or to exercise in health and how it alters in heart disease.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 135 (estimated)
- First submitted
- 19 Feb 2019
- Start date
- 30 Jul 2018
- Primary completion date
- 1 Jan 2030
- Lead sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
- Diseases
- Heart failure, Coronary artery disease, Pulmonary arterial hypertension, High blood pressure
- NCT number
- NCT03854071
What you commit to
- Study type: Interventional
- Planned participants: 135
- From 30 Jul 2018 to the primary completion date, 1 Jan 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindication to MRI (as per standard MRI screening questionnaire issued to patients prior to clinical MRI procedures)
Other illness
- Inability to perform the study protocol secondary to severe heart failure requiring IV therapy
- Patients recruited in the suspected CAD and acute myocardial infarction arms of the study and in need for detection of ischaemia should not have any past medical history of MI, ACS or cardiomyopathy
- Patients with significant valvular heart disease will be excluded from any patient group
Other
- Patient with in atrial fibrillation will be excluded
Who the study is looking for
- Healthy Volunteers age 20 to 80, recruited from Sheffield Teaching Hospitals staff members
- Patients age 20 to 80 with suspected or known heart disease (group 1 to 5)
- Capable of giving written informed consent
Age in the registry: 20 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sheffield Teaching Hospitals NHS FT Coordinator of this site? Confirm its status | Sheffield | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.