Links between symptoms and kidney tissue findings in type 2 diabetic kidney disease
Examines how kidney tissue changes relate to clinical features in type 2 diabetes.
Plain-language title generated from the registry record
Registry title: Correlation Study Between Clinical Phenotype and Pathology of Type 2 Diabetic Nephropathy
Key facts
- Where
- Beijing, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with type 2 diabetes who have kidney damage and have had a kidney biopsy with a complete pathology report.
- Age
- 18 years or older
- Sex
- Men and women can join.
- Disease stage
- Type 2 diabetes with kidney impairment: small amounts of albumin in the urine (microalbuminuria), clear protein in the urine (overt proteinuria), or reduced kidney function (renal insufficiency).
Main reasons for not taking part
- Incomplete history of the disease
- Other secondary kidney diseases
- Hereditary kidney disease
- Autoimmune diseases
- Pregnancy or breastfeeding
Read by machine on 9 November 2026.
Where in China
- Chinese PLA General HospitalBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Chinese PLA General Hospital
- Trial code
- NCT03865914
- Record updated
- 31 March 2022
- Original description
With the rapid increase of diabetic nephropathy worldwide, type 2 diabetes mellitus(DM) is the leading cause of end-stage renal disease(ESRD). Pathological types of diabetic kidney disease(DKD) could be mainly divided into diabetic nephropathy（DN）and non-diabetic renal diseases（NDRD）. There are no accurate renal biopsy indications and standardized operation procedures for type 2 diabetic nephropathy. The clinical stages of type 2 diabetic nephropathy still referred to the Mogensen stage of type 1 diabetic nephropathy. Thus, our study aim to clarify the differences in clinical phenotype between type 2 DN and type 2 NDRD, analysis the correlation between clinical and pathological features, and offer the criteria for clinical staging and prognosis.Read full original descriptionShow less
Correlation Study Between Clinical Phenotype and Pathology of Type 2 Diabetic Nephropathy
With the rapid increase of diabetic nephropathy worldwide, type 2 diabetes mellitus(DM) is the leading cause of end-stage renal disease(ESRD). Pathological types of diabetic kidney disease(DKD) could be mainly divided into diabetic nephropathy（DN）and non-diabetic renal diseases（NDRD）. There are no accurate renal biopsy indications and standardized operation procedures for type 2 diabetic nephropathy. The clinical stages of type 2 diabetic nephropathy still referred to the Mogensen stage of type 1 diabetic nephropathy. Thus, our study aim to clarify the differences in clinical phenotype between type 2 DN and type 2 NDRD, analysis the correlation between clinical and pathological features, and offer the criteria for clinical staging and prognosis.
Inclusion: Age≥18, male or female; Clinical diagnosed as type 2 diabetes mellitus; The presence of renal impairment including: microalbuminuria or overt proteinuria or renal insufficiency; The renal biopsy was performed with complete renal pathological diagnosis; Obtaining the signed informed consent from patients.
Exclusion: The history of the disease was not complete; Clinical diagnosed as other secondary renal diseases; Patients with hereditary kidney disease; Autoimmune diseases; Patients with malignant tumor were expected to survive less than 6 months; Pregnancy and lactation.