Ultrasound Imaging Tests Heart Muscle Stiffness in Older Adults
Tests an ultrasound scan of heart muscle stiffness in older adults with diastolic heart failure.
Plain-language title generated from the registry record
Registry title: Noninvasive Elastography Evaluation of Myocardial Stiffness in Elderly Patients With Isolated Diastolic Heart Failure: New Diagnostic Tool?
Key facts
- Where
- Paris, FranceSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 100 years old?
Source: NCT03895541, who can take part
Where in France
- Emmanuel MESSASParis, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- French Cardiology Society
- Trial code
- NCT03895541
- Record updated
- 9 October 2026
- Original description
The new approach propose in this protocol is based on ultrafast ultrasound and remote palpation of tissue by ultrasonic radiation pressure. Ultrafast ultrasound of biological tissues is based on an innovative ultrasound imaging approach that can image very fast soft tissue events at a rate of several thousands of frames per second and provide quantitative mapping of the elasticity of the tissues. This current project aims is to focus on myocardial rigidity in diastole to better assess the function of the heart failure.Read full original descriptionShow less
Noninvasive Elastography Evaluation of Myocardial Stiffness in Elderly Patients With Isolated Diastolic Heart Failure: New Diagnostic Tool?
The new approach propose in this protocol is based on ultrafast ultrasound and remote palpation of tissue by ultrasonic radiation pressure. Ultrafast ultrasound of biological tissues is based on an innovative ultrasound imaging approach that can image very fast soft tissue events at a rate of several thousands of frames per second and provide quantitative mapping of the elasticity of the tissues. This current project aims is to focus on myocardial rigidity in diastole to better assess the function of the heart failure.
General inclusion criteria:; Subjects who have received information about the study and signed the informed consent form; Beneficiary of a social security scheme; Age ≥18 years; Hospitalization in a cardiology department; Specific inclusion criteria:; HFpEF group (preserved left ventricular ejection fraction):; Left ventricular ejection fraction (LVEF) ≥50%; BNP ≥35 pg/mL or NT-proBNP ≥135 pg/mL; At least one of the following:; Echocardiographic structural alteration: left atrial dilatation (biplane volume ≥34 mL/m²) or left ventricular hypertrophy (LV mass index ≥115 g/m² in men or ≥95 g/m² in women); Echocardiographic functional alteration: criteria of diastolic dysfunction including E >50 cm/s, mean septal-lateral e' <9 cm/s, E/e' ≥13, or peak tricuspid regurgitation velocity ≥2.8 m/s; For 25 patients: documented cardiac amyloidosis; HFmrEF group (moderately reduced left ventricular ejection fraction):; LVEF between 40% and 49%; BNP ≥35 pg/mL or NT-proBNP ≥135 pg/mL; At least one of the following:; Echocardiographic structural alteration: left atrial dilatation (biplane volume ≥34 mL/m²) or left ventricular hypertrophy (LV mass index ≥115 g/m² in men or ≥95 g/m² in women); Echocardiographic functional alteration: criteria of diastolic dysfunction including mean septal-lateral e' <9 cm/s, E/e' ≥13, or peak tricuspid regurgitation velocity ≥2.8 m/s; HFrEF group (reduced left ventricular ejection fraction):; Diagnosis of heart failure with reduced ejection fraction according to the ESC Guidelines; Presence of symptoms of heart failure; Presence of clinical signs of heart failure; LVEF <40%; General exclusion criteria:; Pregnancy; Poor echogenicity; Allergy to echocardiography gel; Specific exclusion criteria:; HFpEF group:; Associated pulmonary disease; Regional wall motion abnormality; HFmrEF group:; Associated pulmonary disease.