Light-based eye scan to measure retinal cell changes in dry macular degeneration and glaucoma
Tests a light-based eye scan in adults with glaucoma or dry macular degeneration.
Plain-language title generated from the registry record
Registry title: Retinal Photoreceptor Outer Segment Length Before and After Light Stimulation - a Pilot Study
Key facts
- Where
- Vienna, AustriaSee the site
Where in Austria
- Medical University of Vienna, Department of Clinical PharmacologyVienna, AustriaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Medical University of Vienna
- Trial code
- NCT03921931
- Record updated
- 16 May 2025
- Original description
It has been shown that reactions of human retinal photoreceptors to a light stimulus can be measured with custom-made, research prototype optical coherence tomography (OCT) systems. This can be used as a biomarker for the function of the photoreceptors. Due to the high technical demands on the system, however, the technique is currently not available for clinical purposes. In this pilot study a protocol to measure changes in retinal photoreceptor layer thickness before and after light stimulation shall be developed based on a commercial OCT system and newly developed algorithms. Other variables, such as circadian processes shall be investigated as well. After measurements in healthy volunteers, the protocol is planned to be applied in patients with primary open angle glaucoma (POAG) and age-related macular degeneration (AMD) to test for feasibility of the method in these patient groups.Read full original descriptionShow less
Assessment of Retinal Photoreceptor Outer Segment Length With Optical Coherence Tomography Before and After Light Stimulation - a Pilot Study
It has been shown that reactions of human retinal photoreceptors to a light stimulus can be measured with custom-made, research prototype optical coherence tomography (OCT) systems. This can be used as a biomarker for the function of the photoreceptors. Due to the high technical demands on the system, however, the technique is currently not available for clinical purposes. In this pilot study a protocol to measure changes in retinal photoreceptor layer thickness before and after light stimulation shall be developed based on a commercial OCT system and newly developed algorithms. Other variables, such as circadian processes shall be investigated as well. After measurements in healthy volunteers, the protocol is planned to be applied in patients with primary open angle glaucoma (POAG) and age-related macular degeneration (AMD) to test for feasibility of the method in these patient groups.
Inclusion: men and women aged over 18 years; signed informed consent form; ametropia below 3 diopters; ability and willingness to follow instructions; for healthy volunteers:; normal ophthalmologic findings; for primary open angle glaucoma patients (POAG):; diagnosed POAG; MD <= 10 dB; for age-related macular degeneration (AMD):; diagnosed dry AMD; diagnosed stage II or stage III AMD.
Exclusion: Use of photosensitizing medication (phototoxic drugs, photoallergic drugs) in the 3 months preceding the study; Ocular surgery in the 3 months preceding the study; Ocular inflammation and ocular disease interfering with the study aims; Presence of any condition with the possibility of causing photosensitivity, including systemic lupus erythematosus SLE, Porphyria, Vitiligo, Xeroderma Pigmentosum and Albinism; Presence of any form of epilepsy; Any medical or surgical history, disorder or disease such as acute or chronic severe organic disease; Presence of any abnormalities preventing reliable measurements; Pregnancy, planned pregnancy or lactating.