CompletedNo phase
Danish RAndomized Trial of External Ventricular Drainage Cessation IN Aneurysmal Subarachnoid Haemorrhage
Key facts
- Who runs it
- Copenhagen University Hospital, Rigshospitalet
- Where
- Denmark and Norway4 sites in 2 countriesChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 245 people enrolled
- Started
- 6 Jun 2019
- Ended
- 18 Jun 2024
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Control intervention
- Experimental intervention
- Record updated
- 25 June 2024
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- >= 18 years of age
- Diagnosis of aneurysmal subarachnoid haemorrhage (aSAH)
- External ventricular drain (EVD) for >= 6 days
- Drain output of =< 220 mL on day of randomisation
- Drain resistance of 10 or 15 cm H2O
- Stable or improving Glasgow Coma Scale (GCS) >= 9 during the last 24 hours
- Signed informed consent (from patient or next-of-kin)
Who cannot take part
- None-tolerability of an increase of resistance to 10 cm H2O due to clinical deterioration or an increase in ICP
- Severe pre-existing (physical or mental) disability or severe co-morbidity that would lead to poor outcome even if the patient made a full recovery from the aSAH
- Life expectancy shorter than 48 hours after admission
This trial has no sites in United States.
It has sites in 2 countries. Choose a country to see its sites.
About the trial
What the trial wants to find out
The DRAIN trial is an international multi-centre, 1:1 randomised, parallel-group, superiority clinical trial investigating gradual weaning vs. prompt closure of external ventricular drainage in patients with hydrocephalus following aSAH.
Read full original descriptionShow less
The primary objective is to investigate the beneficial and harmful effects of gradual weaning versus prompt closure of EVD treatment in patients with aSAH.
The 2 groups in the trial
- Control interventionExisting treatment, for comparison
Prompt closure, based on best available scientific data
- Experimental interventionTreatment being tested
Gradual weaning, based on best available scientific data
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Danish RAndomized Trial of External Ventricular Drainage Cessation IN Aneurysmal Subarachnoid Haemorrhage (DRAIN)
- Record updated
- 25 June 2024