Pharmacogenetics of Antidepressant-Induced Disinhibition
Key facts
- Where
- Calgary, CanadaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 6 and 17 years old?
Source: NCT03953014, who can take part
Where in Canada
- Child and Adolescent Addiction, Mental Health & PsychiatryCalgary, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Calgary
- Trial code
- NCT03953014
- Record updated
- 14 May 2026
- Original description
The purpose of this study is to identify pharmacogenetic profiles associated with selective serotonin reuptake inhibitors (SSRI)-induced behavioral disinhibition in children with Major depressive disorder (MDD), anxiety disorders and/or obsessive-compulsive disorder (OCD) that could be used clinically to reduce the incidence of this adverse event and improve health outcomes.Read full original descriptionShow less
Pharmacogenetics of Antidepressant-Induced Disinhibition in Children Study
The purpose of this study is to identify pharmacogenetic profiles associated with selective serotonin reuptake inhibitors (SSRI)-induced behavioral disinhibition in children with Major depressive disorder (MDD), anxiety disorders and/or obsessive-compulsive disorder (OCD) that could be used clinically to reduce the incidence of this adverse event and improve health outcomes.
Inclusion: Aged 6 - 24 years; Medical records available; Diagnosis of MDD, anxiety disorder, or OCD; Current or past history of SSRI therapy.
Exclusion: Current, past or suspected diagnosis of attention deficit hyperactivity disorder, oppositional defiant disorder, conduct disorder, bipolar disorder, psychotic disorder, or pervasive developmental disorder; Inability of parent/legal guardian to give informed consent; Inability of the child to give informed assent; Unwillingness of child to provide saliva sample for genetic analysis.