Studying immune cell PD-1 in several solid tumors using patient samples
Collects blood and tumor samples from adults with solid cancers to study immune cells.
Plain-language title generated from the registry record
Registry title: Deciphering Mechanisms Underlying Cancer Immunogenicity
Key facts
- Where
- Toulouse, FranceSee the 3 sites
Where in France
- Hopital LarreyToulouse, FranceTaking people
- Hopital RangueilToulouse, FranceTaking people
- Institut Universitaire du Cancer Toulouse - OncopoleToulouse, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Institut Claudius Regaud
- Trial code
- NCT03958240
- Record updated
- 15 September 2025
- Original description
This trial is a translational, open-label, multicentric, prospective cohort study of 1100 patients aiming to describe the PD-1 (programmed death) expression in T cells (T lymphocytes) in different solid tumors.Read full original descriptionShow less
Deciphering Mechanisms Underlying Cancer Immunogenicity
This trial is a translational, open-label, multicentric, prospective cohort study of 1100 patients aiming to describe the PD-1 (programmed death) expression in T cells (T lymphocytes) in different solid tumors.
The study will be conducted on a population of patients with local and/or metastatic malignant solid tumor and who are followed within a standard of care procedure or clinical trial.
Patients with any of the following tumor types may be enrolled in the trial:
* Head and neck cancer, * Ovarian cancer, * Cervical cancer, * Pre-invasive CIN III cervical cancer (Cervical Intra-epithelial Neoplasia III cervical cancer), * Other solid tumor types (including glioblastoma, NSCLC (Non-small cell lung cancer), anal cancer)
Each tumor type will be considered as an independent cohort.
For each included patient, biological specimen (tumor sample, blood samples and ascites samples if applicable) will be collected.
Study participation of each patient will be 5 years.
Inclusion: Patient with histologically documented local or metastatic solid malignant tumor (head and neck, ovarian, cervical, and other tumor types including, but not limited to glioblastoma, NSCLC and anal cancer) or patients with pre-invasive cervical high grade dysplasia (CIN II or III); Age ≥ 18 years at the time of study entry; Patient followed within a standard of care procedure or clinical trial; ECOG Performance status 0-2; Patient able to participate and willing to give informed consent prior performance of any study-related procedures and to comply with the study protocol; Patient affiliated to a Social Health Insurance in France; Patient may participate to other clinical trials.
Exclusion: Known history of positive test for Hepatitis B virus or Hepatitis C virus or Immunodeficiency Virus (HIV) or Hanta virus; Any condition contraindicated with blood sampling procedures required by the protocol (including Hemoglobin < 8g/dl); Patient pregnant, or breast-feeding; Any psychological, familial, geographic or social situation, according to the judgment of investigator, potentially preventing the provision of informed consent or compliance to study procedure; Patient who has forfeited his/her freedom by administrative or legal award or who is under guardianship.