Nasal High Flow Therapy in Surgical Patients with Unrecognized Obstructive Sleep Apnea
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Trial details
- Who runs it
- University Health Network, Toronto
- Trial code
- NCT03964376
- Record updated
- 13 January 2025
- Original description
In this study the investigators will determine whether using high flow oxygen in moderate-to-severe Obstructive Sleep Apnea patients following a major non cardiac surgery is more efficacious than usual care in preventing decrease in oxygen level in blood.Read full original descriptionShow less
Nasal High Flow Therapy Versus Postoperative Usual Care in Surgical Patients with Unrecognized Obstructive Sleep Apnea: a Randomized Controlled Trial (A PHASE 2 STUDY)
In this study the investigators will determine whether using high flow oxygen in moderate-to-severe Obstructive Sleep Apnea patients following a major non cardiac surgery is more efficacious than usual care in preventing decrease in oxygen level in blood.
Inclusion: Adult, age ≥45 years, undergoing major elective non cardiac surgery under general and/or regional anesthesia with anticipated overnight stay or longer in hospital; Patients with untreated moderate-to-severe Obstructive Sleep Apnea; STOP-Bang score 5 or higher.
Exclusion: Predetermined need for postoperative CPAP therapy or ventilation,; Oxygen dependent due to moderate to severe chronic obstructive lung disease available Forced Expiratory Volume at 1 second of < 50% predicted) or advanced interstitial lung disease,; Pre-existing chronic hypercapnia or obesity hypoventilation syndrome, Intracranial and otolaryngological procedures, and; Cheyne-Stokes respiration or Central Apnea,; Unable to use nasal high-flow (nasal/oral malformations, pre-existing tracheostomy, planned postoperative nasal packing).