Molecular Profiling Project
Reason given: Discussion under way on how to continue/restart the study in view of slow recruitment rate.
Key facts
- Where
- George Town, Kuala Lumpur, and Petaling Jaya, MalaysiaSee the 4 sites
Where in Malaysia
- Penang Adventist HospitalGeorge Town, MalaysiaNo longer taking part
- Pantai Hospital Kuala LumpurKuala Lumpur, MalaysiaNo longer taking part
- University Malaya Medical Centre, Clinical Oncology DepartmentKuala Lumpur, MalaysiaNo longer taking part
- Beacon HospitalPetaling Jaya, MalaysiaNo longer taking part
Trial details
- Who runs it
- National Cancer Centre, Singapore
- Trial code
- NCT04025515
- Record updated
- 12 May 2026
- Original description
In this study, the investigators plan to undertake comprehensive molecular profiling of "actionable" alterations in lung cancer specimens in order to determine the prevalence of each genetic subtype in the local population.Read full original descriptionShow less
ATORG001 - Molecular Profiling Project
In this study, the investigators plan to undertake comprehensive molecular profiling of "actionable" alterations in lung cancer specimens in order to determine the prevalence of each genetic subtype in the local population.
Inclusion: The availability of sufficient archival tumor tissue specimen (15 slides of 4 microns per section); Age ≥ 21 years; WHO performance status ≤ 2; Life expectancy of ≥ 12 weeks; Patients should have adequate organ function for potential consideration into clinical trials (routine blood tests are valid within 14 days before enrollment):; Adequate bone marrow function as shown by: ANC ≥ 1.0 x 10\^9/L, Platelets ≥ 75 x 10\^9/L, Hb ≥ 7.5 g/dL; Alanine aminotransferase (ALT) and aspirate aminotransferase (AST) normal range (or ≤3.0 x ULN if liver metastases are present); Willing to provide signed informed consent; Patients whom do not fulfill the above criteria may be discussed on a case-by-case basis with the study team, for potential enrolment.
Exclusion: No more than 3 lines of cytotoxic chemotherapy at the time of enrolment.