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Observes liver cancer recurrence after liver surgery in adults

Observes whether liver cancer returns after surgery in adults with cirrhosis.

Plain-language title generated from the registry record
Registry title: Hepatocarcinoma Recurrence on the Liver Study - Part2

Key facts

Where
Bari, Bologna, Bolzano, Brescia, Forlì, Lecco, Mantua, Milan, Monza, Parma, Pavia, Rome, Rozzano, Savona, Treviso, and Verona, ItalySee the 19 sites

AI summary: who the study is looking for

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for people with hepatocarcinoma confirmed on a tissue sample. They are being treated with surgery, for a first diagnosis or for disease that came back or stayed.

Age
No age limit is stated in the criteria. The record lists a minimum age of 18 Years.
Sex
All sexes can join.
Disease stage
Hepatocarcinoma (liver cancer) confirmed on a tissue sample. It can be a first diagnosis or disease that came back or persisted.
Earlier treatment
People must be treated with surgery at the participating center. People who had other tumors in the past cannot join.

Main reasons for not taking part

  • Surgery done to shrink the disease before a transplant
  • Surgery not meant to remove all of the disease (for example palliation or supportive care only)
  • Tissue sample showing a mixed primary liver tumor (for example hepatocholangiocarcinoma)
  • Other tumors in the past

Read by machine on 12 November 2026.

Where in Italy

  • Chirurgia Rubino - Policlinico di BariBari, ItalyContact: Riccardo Memeo, MDNo longer taking part
  • Ospedale Maggiore- AUSLBologna, ItalyContact: Matteo Zanello, MDNo longer taking part
  • Chirurgia Generale BolzanoBolzano, ItalyContact: Antonio Frena, MDNo longer taking part
  • Fondazione Poliambulanza Istituto OspedalieroBrescia, ItalyContact: Giuseppe Zimmitti, MDNo longer taking part
  • Spedali CiviliBrescia, ItalyContact: Gianluca Baiocchi, MD, PhDNo longer taking part
  • Chirurgia Generale Ospedale Pierantoni - MorgagniForlì, ItalyContact: Giuliano La Barba, MDNo longer taking part
  • Ospedale A. Manzoni - ASST LeccoLecco, ItalyContact: Marco Chiarelli, MDNo longer taking part
  • ASST-MantovaMantua, ItalyContact: Michela De Angelis, MDNo longer taking part
  • Asst-Fbf-Sacco Polo Universitario H. Sacco Chirurgia 2Milan, ItalyContact: Michele Crespi, MDNo longer taking part
  • IRCCS Osp. San Raffaele, Divisione Chirurgia Generale EpatobiliareMilan, ItalyContact: Federica Cipriani, MDNo longer taking part
  • Policlinico di MonzaMonza, ItalyContact: Adelmo Antonucci, MDNo longer taking part
  • UOS Chirurgia Oncologica ad inidirzzo epato-bilio-pancreaticoParma, ItalyContact: Raffaele Dalla Valle, MDNo longer taking part
  • Fondazione IRCCS Policlinico San MatteoPavia, ItalyContact: Marcello Maestri, MD, PhDNo longer taking part
  • Fondazione Policlinico Universitario A. Gemelli IRCCSRome, ItalyContact: Francesco Ardito, ProfNo longer taking part
  • Irccs Istituto Nazionale Tumori Regina ElenaRome, ItalyContact: Valerio De Peppo, MDNo longer taking part
  • Humanitas Research HospitalRozzano, ItalyContact: Matteo Donadon, MD, PhDNo longer taking part
  • Ospedale San PaoloSavona, ItalyContact: Cecilia Ferrari, MDNo longer taking part
  • Chirurgia 4 Ospedale Ca'FoncelloTreviso, ItalyContact: Enrico Lodo, MDNo longer taking part
  • Chirurgia Epatobiliare Università degli studi di VeronaVerona, ItalyContact: Andrea Ruzzenente, MDNo longer taking part

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Trial details

Who runs it
University of Milano Bicocca
Trial code
NCT04053231
Record updated
12 August 2019
Original description
Rationale for the trial. To evaluate the impact of surgery on hepatocarcinoma recurrence. Thus, to evaluate the impact of different clinical, radiological, histopathological variables on recurrence after surgical treatment. The nature of this study will allow to observe, over time, the distribution of the considered collection variables, allowing a strictly observational monitoring of possible associations able to suggest models or interpretations, which can then be the basis for the construction of prospective and randomized studies.Read full original descriptionShow less

Hepatocarcinoma Recurrence on the Liver Study - Part2

Rationale for the trial. To evaluate the impact of surgery on hepatocarcinoma recurrence. Thus, to evaluate the impact of different clinical, radiological, histopathological variables on recurrence after surgical treatment. The nature of this study will allow to observe, over time, the distribution of the considered collection variables, allowing a strictly observational monitoring of possible associations able to suggest models or interpretations, which can then be the basis for the construction of prospective and randomized studies.

Inclusion: No age limit; Hepatocarcinoma diagnosis confirmed at histological specimen; Every single patients with first HCC diagnosis or with a recurrence/persistence disease evaluated and treated with surgery at the participating center; the assessment for patient enrollment must have been performed starting from 02/02/2019.

Exclusion: Surgery as a downstaging therapy for transplant; Patients treated with surgery in case of not-curative intent (palliation, best supportive care, etc); Patients with other tumors in the previous past; Histopathological specimen of combined liver primary neoplasms (e.g. "hepatocholangiocarcinoma'').

ClinicalTrials.gov NCT04053231