Testing urine for tiny particles linked to kidney cancer
Studies urine samples for exosomes in adults with clear cell kidney cancer.
Plain-language title generated from the registry record
Registry title: Evaluation of Urinary Exosomes Presence From Clear Cell Renal Cell Carcinoma
Key facts
- Where
- Saint-Etienne, FranceSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a kidney mass who need surgery to remove part or all of the kidney. A control group of people having an unscheduled nephrectomy can also join.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- A kidney mass that needs surgery (partial or total nephrectomy). The trial studies clear cell renal cell carcinoma.
Main reasons for not taking part
- Urine sample too small (less than 100 ml)
- Having a urinary catheter
- Being under court-ordered guardianship or curatorship
Read by machine on 9 November 2026.
Where in France
- CHU Saint-EtienneSaint-Etienne, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre Hospitalier Universitaire de Saint Etienne
- Trial code
- NCT04053855
- Record updated
- 6 May 2026
- Original description
Clear cell renal cell carcinoma is diagnosed by imaging, sometimes associated with biopsy. This diagnosis is expensive, invasive and sometimes late. The development of a simple biological test for diagnosis is essential. Exosomes are 30 to 150 nm membrane vesicles secreted into the extracellular space by various living cells. These exosomes can be isolated from biological fluids, including urine. The recent study of urinary exosomes is a promising topic for analyzing tumor markers in urine. The investigator's goal is to develop a reliable technique for detecting tumor exosomes in urine in patients with clear cell renal cell carcinoma. The analysis of urinary exosomes could provide a new liquid biopsy tool for the early diagnosis of clear cell renal cell carcinoma.Read full original descriptionShow less
Evaluation of Urinary Exosomes Presence From Clear Cell Renal Cell Carcinoma
Clear cell renal cell carcinoma is diagnosed by imaging, sometimes associated with biopsy. This diagnosis is expensive, invasive and sometimes late. The development of a simple biological test for diagnosis is essential. Exosomes are 30 to 150 nm membrane vesicles secreted into the extracellular space by various living cells. These exosomes can be isolated from biological fluids, including urine. The recent study of urinary exosomes is a promising topic for analyzing tumor markers in urine. The investigator's goal is to develop a reliable technique for detecting tumor exosomes in urine in patients with clear cell renal cell carcinoma. The analysis of urinary exosomes could provide a new liquid biopsy tool for the early diagnosis of clear cell renal cell carcinoma.
Inclusion: Patients:; All patients with renal mass requiring surgery (partial or total nephrectomy); Social security affiliation; Signed informed consent; Control :; Unscheduled nephrectomy; Social security affiliation; Signed informed consent.
Exclusion: Insufficient volume of urine sample (< 100 ml); Patients with a urinary catheter; Patients under court-ordered guardianship or curators.