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Watching Early Cervical Lesions Without Immediate Treatment in Young Women

Follows women aged 18 to 39 with CIN2, a precancerous cervical change, without treatment.

Key facts

Who runs it
University Hospital, Bordeaux
Where
Bordeaux, FranceSee the site
Trial code
Registry title
Therapeutic Abstention and Surveillance of Intra-epithelial Histological Lesions of High Grade Cervical CIN2 (Cervical Intraepithelial Neoplasia Grade 2). SUIVICIN
Status
Recruiting
People taking part
200 people, planned
Started
23 Aug 2019
Expected to end
1 Sept 2029
Type of study
Observational
Treatments tested
  • abstention from CIN2 treatment and surveillance for at least 2 years
Record updated
10 February 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for women aged 18 to 39 with a CIN2 lesion of the cervix, confirmed by biopsy. They are followed with check-ups instead of immediate surgery, to see if the lesion goes away on its own.

Age
18 to 39 years
Sex
Women only
Disease stage
CIN2 (grade 2 cervical intraepithelial neoplasia) confirmed by biopsy, with a satisfactory colposcopy that shows the junction and the lesion
Earlier treatment
No previous conization (cone-shaped removal of part of the cervix). No preventive HPV vaccination. No long-term treatment with corticosteroids or immunosuppressants.

Main reasons for not taking part

  • Pregnant now
  • Previous conization
  • Atypical cells, atypical glandular cells or cancer found by chance on a smear
  • Preventive vaccination against HPV
  • History of HIV infection or weakened immune system

The registry criteria, word for word

Show all 11 criteriaShow less

Who can take part

  • CIN2 confirmed by biopsy, age between 18 and 39 years,
  • satisfactory colposcopy identifying the junction and the lesion,
  • affiliated person or beneficiary of a social security scheme,
  • having given their oral agreement and authorization to the processing of their data

Who cannot take part

  • long-term treatment with corticosteroids or immunosuppressants, placement under safeguard of justice,
  • history of conization,
  • atypical or atypical glandular cells or cancer incidentally discovered during smear,
  • active systemic infection requiring treatment, history of HIV infection, congenital or acquired immunodepression,
  • Pregnancy in progress,
  • prophylactic vaccination against HPV,
  • non-compliance with protocol requirements, in particular a supposed lack of compliance with long-term follow-up

Where in France

  • CHU BordeauxBordeaux, FranceContact: Jean-Luc Brun, MD, PhDTaking people

About the trial

What the trial wants to find out

This study proposes to describe and evaluate the rate of spontaneous regression of CIN2 at 2 year of follow up in women between 18 and 39 year old. This follow-up is proposed as an alternative to the treatment of reference (conization) with a possible extension to 4 years

The group in the trial

  • CIN 2 women

    Non-interventional monocentric prospective study taking place at the Bordeaux University Hospital where women with a CIN2 meeting the eligibility criteria will benefit from abstention from treatment and surveillance for at least 2 years

    Treatment: abstention from CIN2 treatment and surveillance for at least 2 years

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Therapeutic Abstention and Surveillance of Intra-epithelial Histological Lesions of High Grade Cervical CIN2 (Cervical Intraepithelial Neoplasia Grade 2). SUIVICIN
Plain-language title
Watching Early Cervical Lesions Without Immediate Treatment in Young WomenGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
10 February 2025