The Efficacy of Low-load Blood Flow Restricted Resistance Before TKR
Key facts
- Who runs it
- University of Aarhus
- Where
- Denmark3 sites in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 86 people enrolled
- Started
- 17 Sept 2019
- Ended
- 1 Apr 2024
- Type of study
- Interventional, 2 groupsOne group gets no study treatment, for comparison.
- Treatments tested
- Low-load blood flow restricted exercise
- Record updated
- 19 September 2024
Who can take part
- Age
- 50 years and older
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 11 criteriaShow less
Who can take part
- Patients ≥ 50 years scheduled for TKA at Horsens- or Silkeborg Regional Hospital
Who cannot take part
- Severe cardiovascular diseases (New York Heart Association class III and IIII), previous stroke incident, thrombosis incident
- Planned other lower limb surgery within 12 months
- Unregulated hypertension (Systolic ≥180 or diastolic ≥110 mmHg)
- Cancer diagnosis and currently undergoing chemo-, immuno-, or radiotherapy
- Traumatic nerve injury in affected limb
- Spinal cord injury
- Pregnancy
- Inadequacy in written and spoken Danish
- an existing prosthesis in the index limb
- living more than 45 minutes from either Horsens Regional Hospital or Silkeborg Regional Hospital
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The primary aim of this study is to investigate the efficacy of 8 weeks of Low-load blood flow restricted exercise (BFRE) compared to receiving standard care only (no preoperative training) before total knee replacement (TKR) on postoperative 30-seconds chair stand test (30s-CST). We hypothesize that 8 weeks of preoperative BFRE will increase chair stand performance 3 months postoperatively. Secondary aims are to investigate the efficacy of 8 weeks of preoperative BFRE compared to receiving standard care only on changes in muscle strength 3 months after TKR and investigate associations to functional capacity and quality of life. Furthermore, it will be investigated if 8 weeks of BFRE induces muscle hypertrophy and increases satellite cell and myonuclei content of the vastus lateralis muscle.
The 2 groups in the trial
- Group 1 (BFRE)Treatment being tested
Low-load blood flow restricted exercise 3/weekly for 8 weeks before TKR 10-min warm-up followed by unilateral leg press and unilateral knee extension
Treatment: Low-load blood flow restricted exercise
- Group 2 (CON)No study treatment, for comparison
No training before TKR
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Efficacy of Low-load Blood Flow Restricted Resistance Exercise in Patients With Knee Osteoarthritis Scheduled for Total Knee Arthroplasty: A Multicenter, Randomized Controlled Trial
- Publications
- The Effect of Blood Flow Restriction Exercise Prior to Total Knee Arthroplasty on Postoperative Physical Function, Lower Limb Strength and Patient-Reported Outcomes: A Randomized Controlled Trial.Scandinavian journal of medicine & science in sports, 2024
- Record updated
- 19 September 2024