Recording Brain Activity During Memory Tasks in People With Epilepsy
Records brain activity during memory games in adults with epilepsy who are having electrode surgery.
Plain-language title generated from the registry record
Registry title: Study of Direct Brain Recording and Stimulation for Memory Enhancement
Key facts
- Where
- Bethesda, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT04095026, who can take part
Where in United States
- National Institutes of Health Clinical CenterBethesda, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Institute of Neurological Disorders and Stroke (NINDS)
- Trial code
- NCT04095026
- Record updated
- 9 November 2026
- Original description
Background:Read full original descriptionShow less
A Study of Direct Brain Recording and Stimulation for Memory Enhancement
Background:
- Epilepsy is a seizure disorder. Sometimes it is treated with surgery. During surgery, electrodes are placed on or in the brain. Researchers want to learn more about memory and the brain. They want to do tests on people who are having epilepsy surgery.
Objective:
- To learn more about memory and brain function by recording brain cell activity during memory tasks.
Eligibility:
- Adults age 18 - 65 who have medically intractable epilepsy and will have electrodes placed to identify the source of their seizures. They must be currently enrolled in protocol 11-N-0051.
Design:
* Participants may do memory tests before the electrodes are put in, while they are in place, and after surgery. Researchers may stimulate areas of the brain with small pulses of electricity. * Researchers will start recording brain activity at least 12 hours after electrodes are placed. They will record while participants are awake and asleep. They will record before, during, and after seizures. * Participants may have up to 3 testing sessions daily over the 1-3 weeks the electrodes are in place. Each session will last 20-60 minutes. * Participants will play games on a laptop. Sometimes they may use a button or joystick. This can be done in bed in the hospital. * Participants may be given a list of words and asked to recall them in a short time. * Participants may be given pairs of items and asked to remember how they are related. * Participants may be asked to learn their way around a virtual town on the computer. Their eye movements may be tracked by a small camera.
Exclusion: Candidates will be excluded if they:; -Have any disability that would limit their ability to perform study tasks that examine memory function.
INCLUSION CRITERIA:; To be eligible for entry into the study, candidates must meet all the following criteria:; Be enrolled in 11-N-0051 Epilepsy Surgery; Able to give informed consent; Age greater than or equal to 18 years and less than or equal to 65 years.