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Epigenetic Changes in Psychotherapy of Adolescents With Borderline Personality Pathology

Key facts

Who runs it
University Hospital, Basel, Switzerland
Trial code
Status
Withdrawn
Started
Apr 2022
Ended
Dec 2024
Type of study
Observational
Treatments tested
  • routine psychotherapy for Borderline Personality Disorder (BPD)
Record updated
13 September 2022
Why it stopped
personal changes in study team

Who can take part

Age
14 years to 18 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 7 criteriaShow less

Who can take part

  • adolescents presenting 3 or more criteria for BPD in the Structured clinical interview for the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) axis II personality disorders (SCID-II)

Who cannot take part

  • psychotic disorders
  • pervasive developmental disorders
  • severe somatic or neurological disorders
  • difficulties to understand or comply with instructions
  • severe and persistent substance addiction
  • elevated risk for complications related to blood sampling

About the trial

What the trial wants to find out

The link between epigenetic changes as an effect of psychotherapy has been investigated recently. Genes investigated in these studies were brain-derived neurotrophic factor (BDNF), NR3C1, FKBP51, MAOA and GLUT1. Change in methylation of these genes could be a biomolecular mechanism of psychotherapy induced changes. This study project aims at providing evidence for a biological mechanism of personality disorder interventions in adolescence by investigating the link between epigenetic changes as an effect of psychotherapy. It investigates the correlation between changes in the methylation of the FKBP5 gene and psychotherapy induced changes in symptoms and functioning.

Treatments tested

  • routine psychotherapy for Borderline Personality Disorder (BPD)

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Record updated
13 September 2022