Decision Making, Daily Experiences, and Brain Activity in Young Adult Women
Key facts
- Who runs it
- Mclean Hospital
- Where
- Belmont, United StatesSee the site
- Trial code
- Status
- Completed
- People taking part
- 77 people enrolled
- Started
- 31 Dec 2019
- Ended
- 27 Jun 2025
- Type of study
- Interventional, 2 groups
- Treatments tested
- Speaking Activity
- Talking Activity
- Record updated
- 8 June 2026
Who can take part
- Age
- 18 years to 40 years
- Sex
- Women only
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 23 criteriaShow less
Who can take part
- Normal or corrected to normal vision and hearing
- Verbal and written fluency in English
- Right-handed
- Body mass index of 20-35 kg/m\^2; Additional Inclusion Criteria for Participants with Binge-Eating Disorder:
- DSM-5 binge-eating disorder
Who cannot take part
- Contraindications to MRI (e.g., certain metal implants, claustrophobia)
- Certain medications (e.g., insulin)
- Serious and/or unstable medical diseases and conditions, and certain other medical diseases and conditions
- Current/recent frequent recreational drug use, or history of frequent recreational drug use in early adolescence
- Extreme dietary limitations (e.g., veganism), pervasive food allergies, or limited exposure to popular snack foods
- Current/recent changes in treatment for mental illness
- Personal history of eating disorders or recurrent binge eating
- Personal history of any other mental illness, including serious substance use problems
- First-degree relative with current or past eating or psychotic disorder
- Significant recent change in weight; Additional Exclusion Criteria for Participants with Binge-Eating Disorder:
- Severe mental illness (e.g., psychotic disorder, severe agoraphobia)
- Certain other current/recent mental illness, including severe substance use problems, that would limit study participation or safety
- Recent anorexia nervosa spectrum disorder, avoidant-restrictive food intake disorder, or bulimia nervosa spectrum disorder
- Impaired cognition or other neurological/cognitive problems
- Currently/recently/potentially pregnant, seeking to become pregnant in the near future, or breastfeeding
- Recent low weight
- Current/recent suicidality
- Study-relevant research experience; Additional Exclusion Criteria for Comparison Participants:
Where in United States
- McLean HospitalBelmont, United States
About the trial
What the trial wants to find out
The investigators are doing a study of women with and without binge-eating disorder to learn more about what happens when people engage in everyday decision-making activities. The investigators are interested in learning more about brain activity during everyday decision-making and how everyday decision-making relates to a variety of daily experiences. Examples of everyday decisions include deciding which product to buy, deciding what to eat for a snack, and deciding how to spend free time.
The 2 groups in the trial
- Speaking Activity and Talking ActivityTreatment being tested
Participants will engage in a speaking activity first and a talking activity second.
Treatment: Speaking Activity and Talking Activity
- Talking Activity and Speaking ActivityTreatment being tested
Participants will engage in a talking activity first and a speaking activity second.
Treatment: Speaking Activity and Talking Activity
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Understanding The Effects of Acute Stressors and Negative Emotion on Eating Behavior in Binge-Eating Disorder: The Role of Stressor-Induced Changes in Reward and Cognitive Control
- Record updated
- 8 June 2026