NCT04187391Completed
The Effects of a Multimodal Approach for the Treatment of PPA
The Effects of a Multimodal Approach for the Treatment of Primary Progressive Aphasia
Source: ClinicalTrials.gov · Last updated 3 Oct 2024
Brief summary (registry, in English)
Primary Progressive Aphasia (PPA) is an untreatable neurodegenerative disorder that disrupts language functions. Available therapies are mainly symptomatic and recently attention has been gained by new techniques that allow for noninvasive brain stimulation such as transcranial direct current stimulation (tDCS). The primary objective of this study is to evaluate whether the application of Active tDCS (anode over the left dorsolateral prefrontal cortex- DLPFC with the cathode over the right supraorbital region) to the scalp during individualized language training, would improve naming abilities in the agrammatic variant of PPA (avPPA) more than use of one methodology alone. The effect of treatment on the clinical symptoms will be related to changes in brain activity (Magnetic Resonance Imaging, MRI and Functional near-infrared spectroscopy fNIRS) and in biological markers, using a multimodal approach. Finally, we will assess the long-term effects of this approach.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 47 (actual)
- First submitted
- 29 Nov 2019
- Start date
- 15 Jan 2020
- Primary completion date
- 31 Mar 2024
- Lead sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
- Diseases
- Frontotemporal dementia
- NCT number
- NCT04187391
What you commit to
- Study type: Interventional
- Participants enrolled: 47
- From 15 Jan 2020 to the primary completion date, 31 Mar 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Presence of any medical or psychiatric illness that could interfere in completing assessments
- Presence of any medical condition that represents a contraindication to tDCS.
Who the study is looking for
- Diagnosis avPPA according to the current clinical criteria (Gorno-Tempini et al., 2011)
- FTD Clinical Dementia Rating (FTD-CDR) score \>0.5 and \<2
Age in the registry: 40 years to 95 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Coordinator of this site? Confirm its status | Brescia | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.