Tests removing the heart's left atrial appendage during bypass surgery
Tests appendage removal and Marshall ligament cutting during bypass surgery in adults with heart disease.
Plain-language title generated from the registry record
Registry title: Effects of Left Atrial Appendage Resection and Marshall Ligament Amputation on Clinical Outcome in Patients Undergoing Off-pump Coronary Artery Bypass
Key facts
- Where
- Beijing, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults having their first off-pump coronary artery bypass surgery on its own. It tests removal of the left atrial appendage plus Marshall ligament amputation during the operation.
- Age
- 18 Years to 80 Years
- Sex
- All sexes can join.
- Disease stage
- Isolated first off-pump coronary artery bypass.
- Earlier treatment
- People with a previous cardiac surgery cannot join.
Main reasons for not taking part
- Atrial fibrillation before surgery or a history of atrial fibrillation
- Another cardiac or non-cardiac surgery at the same time
- Switch to bypass surgery during the operation
- Emergency surgery
- Severe organ dysfunction
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT04220047, who can take part
Where in China
- Fuwai HospitalBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- China National Center for Cardiovascular Diseases
- Trial code
- NCT04220047
- Record updated
- 20 January 2021
- Original description
Surgical occlusion of the left atrial appendage (LAAO) is sometimes performed during the cardiac surgery to reduce long-term risk of stroke.A previous study found that LAAO may be associated with increased risk of postoperative atrial fibrillation.New-onset atrial fibrillation (NOAF) after coronary artery bypass graft is related to an increased short-term and long term risk of stroke and mortality.Marshall ligament amputation may reduce the occurence of atrial fibrillation. However, little is known whether this approach is justified during the coronary artery bypass graft.Therefore, this study aimed to investigate whether LAAO and Marshall ligament amputation during off-pump coronary artery bypass was associated with reduced risks of postoperative new-onset atrial fibrillation and stroke.Read full original descriptionShow less
Fuwai Hospital, Chinese Academy of Medical Science
Surgical occlusion of the left atrial appendage (LAAO) is sometimes performed during the cardiac surgery to reduce long-term risk of stroke.A previous study found that LAAO may be associated with increased risk of postoperative atrial fibrillation.New-onset atrial fibrillation (NOAF) after coronary artery bypass graft is related to an increased short-term and long term risk of stroke and mortality.Marshall ligament amputation may reduce the occurence of atrial fibrillation. However, little is known whether this approach is justified during the coronary artery bypass graft.Therefore, this study aimed to investigate whether LAAO and Marshall ligament amputation during off-pump coronary artery bypass was associated with reduced risks of postoperative new-onset atrial fibrillation and stroke.
Inclusion: isolated first off-pump coronary artery bypass.
Exclusion: Concurrent cardiac or non-cardiac surgery; Intraoperative convert to bypass bypass surgery; Emergency surgery; History of previous cardiac surgery; Preoperative atrial fibrillation or a history of atrial fibrillation; Severe organ dysfunction.