Long-term study of men with newly diagnosed prostate cancer
Follows men newly diagnosed with prostate cancer to study treatment safety and quality of life.
Key facts
- Who runs it
- UMC Utrecht
- Where
- Nieuwegein and Utrecht, NetherlandsSee the 2 sites
- Trial code
- Registry title
- Utrecht Prostate Cohort for Cancer Treatment Intervention Studies and Long-term Evaluation
- Status
- Recruiting
- People taking part
- 1,500 people, planned
- Started
- 5 Feb 2020
- Expected to end
- 5 Feb 2033
- Type of study
- Observational
- Record updated
- 5 March 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for men aged 18 or older with newly diagnosed, biopsy-proven prostate cancer. They are being referred for radiation treatment, prostatectomy, watchful waiting or active surveillance at two named centres in Utrecht.
- Age
- 18 years or older
- Sex
- Men only
- Disease stage
- Newly diagnosed prostate cancer confirmed by tissue examination (histologically proven).
Main reasons for not taking part
- Patients who are mentally incompetent
- People who cannot understand the Dutch language
The registry criteria, word for word
Show all 5 criteriaShow less
Who can take part
- Age ≥ 18 years
- Patients with newly diagnosed histologically proven prostate cancer, referred for radiation treatment to the Radiotherapy Department of the UMC Utrecht or for prostatectomy, watchful waiting or active surveillance to the Urology Department of St. Antonius hospital or the Urology Department of the UMC Utrecht
- Informed consent - at least - for use of routinely collected clinical data and to fill out questionnaires
Who cannot take part
- Mentally incompetent patients
- Inability to understand the Dutch language
Where in Netherlands
- St. Antonius HospitalNieuwegein, NetherlandsContact: Harm H.E. van Melick, MD, PhDTaking people
- University Medical Center UtrechtUtrecht, NetherlandsContact: Frederik R. Teunissen, MDTaking people
About the trial
What the trial wants to find out
Rationale: Prostate cancer is the most common cancer in men worldwide. Survival rates are high due to the typically non-aggressive nature of disease and effective treatments. Radical treatments such as surgery and radiotherapy often cause toxicity and long term side effects. Based on current available literature, the choice for primary therapy for clinically localised prostate cancer has a negative impact on cancer-specific quality of life (QOL). New interventional treatments are being developed. The investigators aim to build a multidisciplinary prostate cancer cohort which will serve as a multi-trial facility for interventional treatment studies. The Trials within Cohorts (TwiCs) design, also known as cohort multiple Randomized Controlled Trial design (cmRCT) will be conducted and as a prospective registry for assessment of long-term safety, performance and effectiveness new treatment interventions.
Read full original descriptionShow less
Objective: To set up a cohort that will serve as a multi-trial platform and facilitate evaluation of new interventional treatment for prostate cancer.
Study design: Observational, prospective cohort study, according to the 'Trials within Cohorts' (TwiCs) design.
Study population: All patients with newly diagnosed histologically proven prostate cancer.
Main study parameters/endpoints: Clinical parameters (e.g. co-morbidity, oncological history, symptoms, imaging, technical and treatment data), clinical endpoints (e.g. toxicity, and survival outcomes) and patient reported outcomes (e.g. QOL).
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Utrecht Prostate Cohort for Cancer Treatment Intervention Studies and Long-term Evaluation
- Plain-language title
- Long-term study of men with newly diagnosed prostate cancerGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 5 March 2026