NCT04231084CompletedPhase 4
Comparison of Vasodilator Response of Inhaled Epoprostenol and Inhaled Nitric Oxide
Acute Hemodynamic Comparison of Inhaled Nitric Oxide and Inhaled Epoprostenol in Pulmonary Hypertension
Source: ClinicalTrials.gov · Last updated 6 Aug 2024
Brief summary (registry, in English)
The overarching goal of this study is to examine the acute vasoreactive response to both inhaled nitric oxide and inhaled epoprostenol across both traditionally and non-traditionally interrogated phenotypes in PH, and to further characterize the relationship of vasoreactivity to disease severity and PH phenotype.
- Status (registry)
- Completed
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 115 (actual)
- First submitted
- 8 Jan 2020
- Start date
- 15 Jan 2021
- Primary completion date
- 1 Aug 2024
- Lead sponsor
- Brigham and Women's Hospital
- NCT number
- NCT04231084
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 115
- From 15 Jan 2021 to the primary completion date, 1 Aug 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who are on baseline pulmonary vasodilator medications
Other illness
- WHO group IV and V pulmonary hypertension
- Severe aortic or mitral valve disease
Lab values
- Left ventricular ejection fraction of \<35%
Other
- Patients who are pregnant
- Patients who are hospitalized as inpatients at the time of RHC
- Patients with systolic blood pressure \<90mmHg or mean arterial pressure of \< 60mmHg
Who the study is looking for
- mPAP ≥ 21mmHg, PAWP ≤ 25mmHg, and PVR ≥3 WU
- Classified as WHO group I-III pulmonary hypertension
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Brigham and Women's Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.