Taking people in United StatesPhase 3
Early versus delayed treatment with venetoclax and obinutuzumab for high-risk leukemia
Tests starting venetoclax and obinutuzumab early in adults with newly found high-risk leukemia.
Plain-language title generated from the registry record
Registry title: Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study
Key facts
- Where
- Aberdeen, Adrian, Albuquerque, Allentown, Alton, Ames, Anaconda, Anaheim, Anchorage, Ankeny, Ann Arbor, Antigo, Appleton, Arroyo Grande, Ashland, Auburn, Augusta, Aurora, Baker City, Baldwin Park, Ballwin, Baltimore, Bardstown, Basking Ridge, Baton Rouge, Battle Creek, Beavercreek, Bellevue, Bellflower, Bellingham, Belpre, Bend, Bethesda, Bethlehem, Billings, Birmingham, Bloomington, Boardman, Boiling Springs, Boise, Bolivar, Boone, Boston, Boulder, Bozeman, Brighton, Bristol, Brownstown, Brunswick, Bryan, Burbank, Burien, Burnsville, Burr Ridge, Caldwell, Cambridge, Camden, Cameron Park, Camillus, Canton, Cape Girardeau, Carbondale, Carmichael, Caro, Carroll, Carterville, Carthage, Cedar Rapids, Centennial, Centerville, Centralia, Chadds Ford, Chapel Hill, Charleston, Chelsea, Chesterfield, Cheyenne, Chicago, Chico, Chillicothe, Cincinnati, City of Saint Peters, Clackamas, Clarkston, Cleveland, Clinton, Clinton Township, Clive, Cody, Coeur d'Alene, Collierville, Colorado Springs, Columbus, Commack, Coon Rapids, Coos Bay, Corbin, Costa Mesa, Council Bluffs, Creston, Creve Coeur, Crown Point, Dallas, Damariscotta, Danville, Dayton, Dearborn, Decatur, Deer River, DeKalb, Delaware, Denver, Des Moines, Detroit, Dixon, Duarte, Dublin, Duluth, Durango, Durham, Easley, East China Township, East Stroudsburg, East Syracuse, Eau Claire, Edina, Edinburg, Edmonds, Effingham, Elk Grove, Elmhurst, Emmett, Englewood, Enumclaw, Eureka, Evanston, Everett, Fairbanks, Farmington, Federal Way, Findlay, Flint, Fontana, Fort Dodge, Fort Lauderdale, Fort Smith, Franklin, Fridley, Fruitland, Gahanna, Galesburg, Garden City, Geneva, Glens Falls, Glenview, Golden, Goldsboro, Grand Island, Grand Junction, Grand Rapids, Grayslake, Great Bend, Great Falls, Greeley, Green Bay, Greenville, Greer, Grenada, Grosse Pointe Woods, Grove City, Harbor City, Harrison, Harvey, Hays, Hazleton, Hendersonville, Hibbing, Highland Park, Hillsborough, Homer Glen, Hot Springs, Huntington Beach, Indianapolis, Irvine, Issaquah, Jackson, Jacksonville, Jefferson, Jefferson City, Jersey City, Jonesboro, Joplin, Kalamazoo, Kalispell, Kansas City, Kearney, Kenansville, Kennewick, Kettering, Kewanee, Kingsport, Kinston, Kirkland, La Crosse, Lacey, Lafayette, Laguna Hills, Lake Forest, Lakewood, Lancaster, Lansing, Las Cruces, Las Vegas, Lawrence, Lebanon, Lee's Summit, Lewes, Lexington, Lima, Lincoln, Littleton, Livonia, London, Lone Tree, Long Beach, Long Branch, Longmont, Longview, Los Angeles, Louisville, Loveland, Macomb, Madison, Mansfield, Maple Grove, Maplewood, Marietta, Marion, Marlette, Marshalltown, Marshfield, Marysville, Mattoon, Mayfield Heights, Maywood, Medford, Melrose Park, Memphis, Meridian, Middletown, Millville, Milwaukee, Minneapolis, Minocqua, Missoula, Monroe, Monticello, Montvale, Mount Vernon, Muskegon, Nampa, Naperville, Nashville, New Albany, New Brunswick, New Lenox, New Orleans, New Richmond, New Ulm, New York, Newark, Newberg, Newport Beach, Niles, Norton, Norton Shores, Novi, O'Fallon, Oconto Falls, Oklahoma City, Olathe, Omaha, Ontario, Orange, Oregon City, Orland Park, Oswego, Ottawa, Overland Park, Oxford, Palo Alto, Panorama City, Papillion, Parker, Pekin, Pensacola, Peoria, Perrysburg, Peru, Philadelphia, Phoenix, Pittsburgh, Plainfield, Pontiac, Port Townsend, Portland, Portsmouth, Post Falls, Poulsbo, Princeton, Pueblo, Redmond, Reed City, Rehoboth Beach, Rhinelander, Rice Lake, Richardson, Richlands, Richmond, Rio Rancho, Riverside, Robbinsdale, Rochester, Rockford, Rocklin, Rolla, Sacramento, Saginaw, Saint Cloud, Saint Joseph, Saint Louis Park, Saint Paul, Sainte Genevieve, Salina, Salt Lake City, San Diego, San Luis Obispo, San Marcos, Sandpoint, Sandstone, Santa Maria, Scarborough, Seaford, Seattle, Sedro-Woolley, Seneca, Shakopee, Sheboygan, Shelby, Shelton, Shepherdsville, Sheridan, Shreveport, Silverdale, South Pasadena, South Portland, Southfield, Southhaven, Springfield, St Louis, Sterling Heights, Stevens Point, Stillwater, Stoneham, Sullivan, Sylvania, Syracuse, Tacoma, Tawas City, Thornton, Toledo, Toms River, Topeka, Torrance, Traverse City, Troy, Tucson, Twin Falls, Uniondale, Upland, Urbana, Vancouver, Verona, Virginia, Voorhees Township, Waconia, Walla Walla, Warren, Warrenville, Washington, Washington D.C., Waukee, Wausau, Webster, West Bloomfield, West Branch, West Chester, West Des Moines, Westerville, Weston, Westwood, Wilkes-Barre, Willmar, Willow Grove, Wilmington, Wisconsin Rapids, Woodbury, Woodland, Woodland Hills, Wright-Patterson Air Force Base, Wyandotte, Wyoming, Yakima, Yelm, Yorkville, Youngstown, Ypsilanti, and Zanesville, United StatesSee the 625 sites
- Phase
- Phase 3
Where in United States
- Providence Regional Cancer System-AberdeenAberdeen, United StatesNo longer taking part
- Hickman Cancer CenterAdrian, United StatesNo longer taking part
- Presbyterian Kaseman HospitalAlbuquerque, United StatesNo longer taking part
- University of New Mexico Cancer CenterAlbuquerque, United StatesNo longer taking part
- Lehigh Valley Hospital-Cedar CrestAllentown, United StatesTaking people
- OSF Saint Anthony's Health CenterAlton, United StatesNo longer taking part
- Mary Greeley Medical CenterAmes, United StatesTaking people
- McFarland Clinic - AmesAmes, United StatesTaking people
- Community Hospital of AnacondaAnaconda, United StatesTaking people
- Kaiser Permanente-AnaheimAnaheim, United StatesTaking people
- Alaska Breast Care and Surgery LLCAnchorage, United StatesNo longer taking part
- Alaska Oncology and Hematology LLCAnchorage, United StatesNo longer taking part
- Alaska Women's Cancer CareAnchorage, United StatesNo longer taking part
- Anchorage Associates in Radiation MedicineAnchorage, United StatesNo longer taking part
- Anchorage Oncology CentreAnchorage, United StatesNo longer taking part
- Anchorage Radiation Therapy CenterAnchorage, United StatesNo longer taking part
- Katmai Oncology GroupAnchorage, United StatesNo longer taking part
- Providence Alaska Medical CenterAnchorage, United StatesNo longer taking part
- UI Health Care Mission Cancer and Blood - Ankeny ClinicAnkeny, United StatesTaking people
- Trinity Health Saint Joseph Mercy Hospital Ann ArborAnn Arbor, United StatesTaking people
- Aspirus Cancer Care-Antigo-Volm Cancer CenterAntigo, United StatesTaking people
- ThedaCare Regional Cancer CenterAppleton, United StatesNo longer taking part
- Mission Hope Medical Oncology - Arroyo GrandeArroyo Grande, United StatesNo longer taking part
- Duluth Clinic AshlandAshland, United StatesTaking people
- Hematology Oncology Associates of Central New York-AuburnAuburn, United StatesNo longer taking part
- Harold Alfond Center for Cancer CareAugusta, United StatesTaking people
- Rocky Mountain Cancer Centers-AuroraAurora, United StatesNo longer taking part
- Rush-Copley Medical CenterAurora, United StatesNo longer taking part
- The Medical Center of AuroraAurora, United StatesNo longer taking part
- Saint Alphonsus Cancer Care Center-Baker CityBaker City, United StatesNo longer taking part
- Kaiser Permanente-Baldwin ParkBaldwin Park, United StatesTaking people
- Mercy Oncology and Hematology - Clayton-ClarksonBallwin, United StatesNo longer taking part
- Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimore, United StatesTaking people
- CommonSpirit Saint Joseph Hospital - BardstownBardstown, United StatesNo longer taking part
- Memorial Sloan Kettering Basking RidgeBasking Ridge, United StatesTaking people
- Hematology/Oncology Clinic PLLCBaton Rouge, United StatesNo longer taking part
- Bronson Battle CreekBattle Creek, United StatesTaking people
- Indu and Raj Soin Medical CenterBeavercreek, United StatesNo longer taking part
- FHCC OverlakeBellevue, United StatesTaking people
- Kaiser Permanente-BellflowerBellflower, United StatesTaking people
- PeaceHealth Saint Joseph Medical CenterBellingham, United StatesNo longer taking part
- Strecker Cancer Center-BelpreBelpre, United StatesNo longer taking part
- Saint Charles Health SystemBend, United StatesTaking people
- Walter Reed National Military Medical CenterBethesda, United StatesTaking people
- Lehigh Valley Hospital - MuhlenbergBethlehem, United StatesTaking people
- Billings Clinic Cancer CenterBillings, United StatesTaking people
- Saint Vincent Frontier Cancer CenterBillings, United StatesNo longer taking part
- Saint Vincent HealthcareBillings, United StatesNo longer taking part
- University of Alabama at Birmingham Cancer CenterBirmingham, United StatesNo longer taking part
- Illinois CancerCare-BloomingtonBloomington, United StatesNo longer taking part
- Saint Elizabeth Boardman HospitalBoardman, United StatesNo longer taking part
- Prisma Health Cancer Institute - SpartanburgBoiling Springs, United StatesTaking people
- Saint Alphonsus Cancer Care Center-BoiseBoise, United StatesTaking people
- Saint Luke's Cancer Institute - BoiseBoise, United StatesNo longer taking part
- Central Care Cancer Center - BolivarBolivar, United StatesNo longer taking part
- McFarland Clinic - BooneBoone, United StatesNo longer taking part
- Dana-Farber Cancer InstituteBoston, United StatesTaking people
- Tufts Medical CenterBoston, United StatesTaking people
- Boulder Community Foothills HospitalBoulder, United StatesNo longer taking part
- Rocky Mountain Cancer Centers-BoulderBoulder, United StatesNo longer taking part
- Bozeman Health Deaconess HospitalBozeman, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, United StatesTaking people
- Trinity Health Medical Center - BrightonBrighton, United StatesTaking people
- Ballad Health Cancer Care - BristolBristol, United StatesTaking people
- Bristol Regional Medical CenterBristol, United StatesNo longer taking part
- Henry Ford Cancer Institute-DownriverBrownstown, United StatesTaking people
- MaineHealth Cancer Care and IV Therapy - BrunswickBrunswick, United StatesTaking people
- Mid Coast HospitalBrunswick, United StatesTaking people
- Saint Joseph Regional Cancer CenterBryan, United StatesNo longer taking part
- Providence Saint Joseph Medical Center/Disney Family Cancer CenterBurbank, United StatesNo longer taking part
- Saint Anne HospitalBurien, United StatesNo longer taking part
- Fairview Ridges HospitalBurnsville, United StatesNo longer taking part
- Minnesota Oncology - BurnsvilleBurnsville, United StatesNo longer taking part
- Loyola Center for Health at Burr RidgeBurr Ridge, United StatesNo longer taking part
- Saint Alphonsus Cancer Care Center-CaldwellCaldwell, United StatesTaking people
- Cambridge Medical CenterCambridge, United StatesNo longer taking part
- Cooper Hospital University Medical CenterCamden, United StatesTaking people
- Marshall Cancer CenterCameron Park, United StatesTaking people
- Hematology Oncology Associates of CNY at CamillusCamillus, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, United StatesTaking people
- Trinity Health Medical Center - CantonCanton, United StatesTaking people
- Cleveland Clinic Mercy HospitalCanton, United StatesNo longer taking part
- Illinois CancerCare-CantonCanton, United StatesNo longer taking part
- Saint Francis Medical CenterCape Girardeau, United StatesTaking people
- Mercy Cancer Center - Cape GirardeauCape Girardeau, United StatesNo longer taking part
- Memorial Hospital of CarbondaleCarbondale, United StatesNo longer taking part
- Mercy Cancer Center - CarmichaelCarmichael, United StatesNo longer taking part
- Mercy San Juan Medical CenterCarmichael, United StatesNo longer taking part
- Caro Cancer CenterCaro, United StatesNo longer taking part
- Saint Anthony Regional HospitalCarroll, United StatesNo longer taking part
- SIH Cancer InstituteCarterville, United StatesNo longer taking part
- Illinois CancerCare-CarthageCarthage, United StatesNo longer taking part
- Physicians' Clinic of Iowa PCCedar Rapids, United StatesTaking people
- Rocky Mountain Cancer Centers - CentennialCentennial, United StatesNo longer taking part
- Dayton Physicians LLC-Miami Valley SouthCenterville, United StatesNo longer taking part
- Miami Valley Hospital SouthCenterville, United StatesNo longer taking part
- Centralia Oncology ClinicCentralia, United StatesNo longer taking part
- Providence Regional Cancer System-CentraliaCentralia, United StatesNo longer taking part
- Christiana Care Health System-Concord Health CenterChadds Ford, United StatesNo longer taking part
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, United StatesTaking people
- Medical University of South CarolinaCharleston, United StatesTaking people
- Ralph H. Johnson VA Medical CenterCharleston, United StatesTaking people
- Chelsea HospitalChelsea, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, United StatesTaking people
- Saint Luke's HospitalChesterfield, United StatesTaking people
- Cheyenne Regional Medical Center-WestCheyenne, United StatesNo longer taking part
- Northwestern UniversityChicago, United StatesTaking people
- University of Chicago Comprehensive Cancer CenterChicago, United StatesTaking people
- Enloe Medical CenterChico, United StatesTaking people
- Adena Regional Medical CenterChillicothe, United StatesNo longer taking part
- Bethesda North HospitalCincinnati, United StatesNo longer taking part
- Good Samaritan Hospital - CincinnatiCincinnati, United StatesNo longer taking part
- Oncology Hematology Care Inc-KenwoodCincinnati, United StatesNo longer taking part
- TriHealth Cancer Institute-AndersonCincinnati, United StatesNo longer taking part
- TriHealth Cancer Institute-WestsideCincinnati, United StatesNo longer taking part
- University of Cincinnati Cancer Center-UC Medical CenterCincinnati, United StatesNo longer taking part
- Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, United StatesNo longer taking part
- Clackamas Radiation Oncology CenterClackamas, United StatesTaking people
- Providence Cancer Institute Clackamas ClinicClackamas, United StatesNo longer taking part
- Hematology Oncology Consultants-ClarkstonClarkston, United StatesTaking people
- Newland Medical Associates-ClarkstonClarkston, United StatesNo longer taking part
- Cleveland Clinic Cancer Center/Fairview HospitalCleveland, United StatesTaking people
- Cleveland Clinic FoundationCleveland, United StatesTaking people
- Southeastern Medical Oncology Center-ClintonClinton, United StatesTaking people
- Henry Ford Macomb Hospital-Clinton TownshipClinton Township, United StatesTaking people
- UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, United StatesTaking people
- Mercy Cancer Center-West LakesClive, United StatesNo longer taking part
- Billings Clinic-CodyCody, United StatesNo longer taking part
- Kootenai Health - Coeur d'AleneCoeur d'Alene, United StatesTaking people
- Baptist Memorial Hospital and Cancer Center-ColliervilleCollierville, United StatesTaking people
- Penrose-Saint Francis HealthcareColorado Springs, United StatesNo longer taking part
- Rocky Mountain Cancer Centers-PenroseColorado Springs, United StatesNo longer taking part
- Baptist Memorial Hospital and Cancer Center-Golden TriangleColumbus, United StatesTaking people
- Ohio State University Comprehensive Cancer CenterColumbus, United StatesTaking people
- Columbus Oncology and Hematology Associates IncColumbus, United StatesNo longer taking part
- Doctors HospitalColumbus, United StatesNo longer taking part
- Grant Medical CenterColumbus, United StatesNo longer taking part
- Mount Carmel East HospitalColumbus, United StatesNo longer taking part
- Mount Carmel Health Center WestColumbus, United StatesNo longer taking part
- Riverside Methodist HospitalColumbus, United StatesNo longer taking part
- The Mark H Zangmeister CenterColumbus, United StatesNo longer taking part
- Memorial Sloan Kettering CommackCommack, United StatesTaking people
- Mercy HospitalCoon Rapids, United StatesTaking people
- Bay Area HospitalCoos Bay, United StatesNo longer taking part
- Commonwealth Cancer Center-CorbinCorbin, United StatesNo longer taking part
- UC Irvine Health Cancer Center-NewportCosta Mesa, United StatesTaking people
- Alegent Health Mercy HospitalCouncil Bluffs, United StatesNo longer taking part
- Greater Regional Medical CenterCreston, United StatesNo longer taking part
- Siteman Cancer Center at West County HospitalCreve Coeur, United StatesNo longer taking part
- UChicago Medicine Northwest IndianaCrown Point, United StatesTaking people
- UT Southwestern/Simmons Cancer Center-DallasDallas, United StatesNo longer taking part
- MaineHealth LincolnHealth HospitalDamariscotta, United StatesTaking people
- Carle at The RiverfrontDanville, United StatesTaking people
- Geisinger Medical CenterDanville, United StatesTaking people
- Dayton Physician LLC - EnglewoodDayton, United StatesNo longer taking part
- Miami Valley HospitalDayton, United StatesNo longer taking part
- Miami Valley Hospital NorthDayton, United StatesNo longer taking part
- Henry Ford Medical Center-FairlaneDearborn, United StatesTaking people
- Cancer Care Specialists of Illinois - DecaturDecatur, United StatesTaking people
- Decatur Memorial HospitalDecatur, United StatesNo longer taking part
- Essentia Health - Deer River ClinicDeer River, United StatesTaking people
- Northwestern Medicine Cancer Center KishwaukeeDeKalb, United StatesTaking people
- Delaware Health Center-Grady Cancer CenterDelaware, United StatesNo longer taking part
- Grady Memorial HospitalDelaware, United StatesNo longer taking part
- AdventHealth PorterDenver, United StatesNo longer taking part
- Cancer Center of Colorado at Sloan's LakeDenver, United StatesNo longer taking part
- Colorado Blood Cancer InstituteDenver, United StatesNo longer taking part
- National Jewish Health-Main CampusDenver, United StatesNo longer taking part
- Presbyterian - Saint Lukes Medical Center - Health OneDenver, United StatesNo longer taking part
- Rocky Mountain Cancer Centers-MidtownDenver, United StatesNo longer taking part
- Rocky Mountain Cancer Centers-RoseDenver, United StatesNo longer taking part
- Rose Medical CenterDenver, United StatesNo longer taking part
- Saint Joseph Hospital - Cancer Centers of ColoradoDenver, United StatesNo longer taking part
- The Women's Imaging CenterDenver, United StatesNo longer taking part
- Western Surgical CareDenver, United StatesNo longer taking part
- Broadlawns Medical CenterDes Moines, United StatesTaking people
- Iowa Methodist Medical CenterDes Moines, United StatesTaking people
- Mercy Medical Center - Des MoinesDes Moines, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Des Moines ClinicDes Moines, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, United StatesTaking people
- Iowa Lutheran HospitalDes Moines, United StatesNo longer taking part
- Henry Ford Health Saint John HospitalDetroit, United StatesTaking people
- Henry Ford HospitalDetroit, United StatesTaking people
- Illinois CancerCare-DixonDixon, United StatesNo longer taking part
- City of Hope Comprehensive Cancer CenterDuarte, United StatesTaking people
- Dublin Methodist HospitalDublin, United StatesNo longer taking part
- Essentia Health Cancer CenterDuluth, United StatesTaking people
- CommonSpirit Cancer Center MercyDurango, United StatesNo longer taking part
- Mercy Medical CenterDurango, United StatesNo longer taking part
- Duke University Medical CenterDurham, United StatesTaking people
- Durham VA Medical CenterDurham, United StatesNo longer taking part
- Prisma Health Cancer Institute - EasleyEasley, United StatesTaking people
- Henry Ford River District HospitalEast China Township, United StatesTaking people
- Pocono Medical CenterEast Stroudsburg, United StatesNo longer taking part
- Hematology Oncology Associates of Central New York-East SyracuseEast Syracuse, United StatesTaking people
- Marshfield Medical Center-EC Cancer CenterEau Claire, United StatesTaking people
- HSHS Sacred Heart HospitalEau Claire, United StatesNo longer taking part
- Fairview Southdale HospitalEdina, United StatesNo longer taking part
- STCC at DHR Health Institute for Research and DevelopmentEdinburg, United StatesNo longer taking part
- Swedish Cancer Institute-EdmondsEdmonds, United StatesTaking people
- Carle Physician Group-EffinghamEffingham, United StatesTaking people
- Crossroads Cancer CenterEffingham, United StatesTaking people
- Mercy Cancer Center - Elk GroveElk Grove, United StatesNo longer taking part
- Elmhurst Memorial HospitalElmhurst, United StatesTaking people
- Walter Knox Memorial HospitalEmmett, United StatesNo longer taking part
- Mountain Blue Cancer Care Center - SwedishEnglewood, United StatesNo longer taking part
- Rocky Mountain Cancer Centers - SwedishEnglewood, United StatesNo longer taking part
- Swedish Medical CenterEnglewood, United StatesNo longer taking part
- The Melanoma and Skin Cancer InstituteEnglewood, United StatesNo longer taking part
- Saint Elizabeth HospitalEnumclaw, United StatesNo longer taking part
- Illinois CancerCare-EurekaEureka, United StatesNo longer taking part
- NorthShore University HealthSystem-Evanston HospitalEvanston, United StatesTaking people
- Providence Regional Cancer PartnershipEverett, United StatesNo longer taking part
- Fairbanks Memorial HospitalFairbanks, United StatesNo longer taking part
- Parkland Health Center - FarmingtonFarmington, United StatesTaking people
- Saint Francis HospitalFederal Way, United StatesNo longer taking part
- Armes Family Cancer CenterFindlay, United StatesNo longer taking part
- Blanchard Valley HospitalFindlay, United StatesNo longer taking part
- Orion Cancer CareFindlay, United StatesNo longer taking part
- Cancer Hematology Centers - FlintFlint, United StatesTaking people
- Genesys Hurley Cancer InstituteFlint, United StatesTaking people
- Hurley Medical CenterFlint, United StatesTaking people
- Genesee Hematology Oncology PCFlint, United StatesNo longer taking part
- Kaiser Permanente-FontanaFontana, United StatesTaking people
- McFarland Clinic - Trinity Cancer CenterFort Dodge, United StatesTaking people
- UI Healthcare Mission Cancer and Blood - Fort DodgeFort Dodge, United StatesNo longer taking part
- Holy Cross HospitalFort Lauderdale, United StatesTaking people
- Mercy Hospital Fort SmithFort Smith, United StatesNo longer taking part
- Atrium Medical Center-Middletown Regional HospitalFranklin, United StatesNo longer taking part
- Dayton Physicians LLC-AtriumFranklin, United StatesNo longer taking part
- Unity HospitalFridley, United StatesNo longer taking part
- Saint Luke's Cancer Institute - FruitlandFruitland, United StatesNo longer taking part
- Central Ohio Breast and Endocrine SurgeryGahanna, United StatesNo longer taking part
- Illinois CancerCare-GalesburgGalesburg, United StatesNo longer taking part
- Western Illinois Cancer Treatment CenterGalesburg, United StatesNo longer taking part
- Central Care Cancer Center - Garden CityGarden City, United StatesNo longer taking part
- Northwestern Medicine Cancer Center DelnorGeneva, United StatesTaking people
- Glens Falls HospitalGlens Falls, United StatesTaking people
- NorthShore University HealthSystem-Glenbrook HospitalGlenview, United StatesTaking people
- Northwestern Medicine Glenview Outpatient CenterGlenview, United StatesTaking people
- National Jewish Health-Western Hematology OncologyGolden, United StatesNo longer taking part
- Southeastern Medical Oncology Center-GoldsboroGoldsboro, United StatesTaking people
- Nebraska Cancer Specialists/Oncology Hematology West PCGrand Island, United StatesNo longer taking part
- Grand Valley OncologyGrand Junction, United StatesTaking people
- Saint Mary's Hospital and Regional Medical CenterGrand Junction, United StatesNo longer taking part
- Corewell Health Grand Rapids Hospitals - Butterworth HospitalGrand Rapids, United StatesTaking people
- Trinity Health Grand Rapids HospitalGrand Rapids, United StatesTaking people
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's HospitalGrand Rapids, United StatesNo longer taking part
- Northwestern Medicine Grayslake Outpatient CenterGrayslake, United StatesTaking people
- Central Care Cancer Center - Great BendGreat Bend, United StatesNo longer taking part
- Benefis Sletten Cancer InstituteGreat Falls, United StatesTaking people
- Great Falls ClinicGreat Falls, United StatesNo longer taking part
- Banner North Colorado Medical CenterGreeley, United StatesNo longer taking part
- Bellin Memorial HospitalGreen Bay, United StatesTaking people
- Saint Vincent Hospital Cancer Center at Saint Mary'sGreen Bay, United StatesNo longer taking part
- Saint Vincent Hospital Cancer Center Green BayGreen Bay, United StatesNo longer taking part
- East Carolina UniversityGreenville, United StatesTaking people
- Prisma Health Cancer Institute - ButternutGreenville, United StatesTaking people
- Prisma Health Cancer Institute - EastsideGreenville, United StatesTaking people
- Prisma Health Cancer Institute - FarisGreenville, United StatesTaking people
- Dayton Physicians LLC-WayneGreenville, United StatesNo longer taking part
- Wayne HospitalGreenville, United StatesNo longer taking part
- Prisma Health Cancer Institute - GreerGreer, United StatesTaking people
- Baptist Cancer Center-GrenadaGrenada, United StatesTaking people
- Henry Ford Saint John Hospital - AcademicGrosse Pointe Woods, United StatesTaking people
- Henry Ford Saint John Hospital - Van ElslanderGrosse Pointe Woods, United StatesTaking people
- Henry Ford Saint John Hospital - BreastGrosse Pointe Woods, United StatesNo longer taking part
- Mount Carmel Grove City HospitalGrove City, United StatesNo longer taking part
- Kaiser Permanente South BayHarbor City, United StatesTaking people
- Memorial Sloan Kettering WestchesterHarrison, United StatesTaking people
- Ingalls Memorial HospitalHarvey, United StatesTaking people
- HaysMedHays, United StatesTaking people
- Lehigh Valley Hospital-HazletonHazleton, United StatesNo longer taking part
- Margaret R Pardee Memorial HospitalHendersonville, United StatesTaking people
- Essentia Health Hibbing ClinicHibbing, United StatesTaking people
- NorthShore University HealthSystem-Highland Park HospitalHighland Park, United StatesTaking people
- University of North Carolina-Hillsborough CampusHillsborough, United StatesTaking people
- Loyola Medicine Homer GlenHomer Glen, United StatesNo longer taking part
- CHI Saint Vincent Cancer Center Hot SpringsHot Springs, United StatesNo longer taking part
- City of Hope SeacliffHuntington Beach, United StatesTaking people
- Indiana University/Melvin and Bren Simon Cancer CenterIndianapolis, United StatesTaking people
- City of Hope at Irvine LennarIrvine, United StatesTaking people
- Kaiser Permanente-IrvineIrvine, United StatesTaking people
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory CareIrvine, United StatesTaking people
- Swedish Cancer Institute-IssaquahIssaquah, United StatesTaking people
- Allegiance HealthJackson, United StatesTaking people
- Southeastern Medical Oncology Center-JacksonvilleJacksonville, United StatesTaking people
- McFarland Clinic - JeffersonJefferson, United StatesNo longer taking part
- MU Health Care Goldschmidt Cancer CenterJefferson City, United StatesNo longer taking part
- Jersey City Medical CenterJersey City, United StatesTaking people
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - JonesboroJonesboro, United StatesTaking people
- Freeman Health SystemJoplin, United StatesNo longer taking part
- Mercy Hospital JoplinJoplin, United StatesNo longer taking part
- Beacon Kalamazoo Cancer CenterKalamazoo, United StatesTaking people
- Bronson Methodist HospitalKalamazoo, United StatesTaking people
- West Michigan Cancer CenterKalamazoo, United StatesTaking people
- Beacon KalamazooKalamazoo, United StatesNo longer taking part
- Logan Health Medical CenterKalispell, United StatesTaking people
- Kansas City Veterans Affairs Medical CenterKansas City, United StatesTaking people
- University Health Truman Medical CenterKansas City, United StatesTaking people
- University of Kansas Cancer CenterKansas City, United StatesTaking people
- University of Kansas Cancer Center - BriarcliffKansas City, United StatesTaking people
- University of Kansas Cancer Center - NorthKansas City, United StatesTaking people
- CHI Health Good SamaritanKearney, United StatesNo longer taking part
- ECU Health Oncology KenansvilleKenansville, United StatesNo longer taking part
- Kadlec Clinic Hematology and OncologyKennewick, United StatesTaking people
- Greater Dayton Cancer CenterKettering, United StatesNo longer taking part
- Kettering Medical CenterKettering, United StatesNo longer taking part
- Illinois CancerCare-Kewanee ClinicKewanee, United StatesNo longer taking part
- Ballad Health Cancer Care - KingsportKingsport, United StatesTaking people
- Wellmont Holston Valley Hospital and Medical CenterKingsport, United StatesNo longer taking part
- ECU Health Oncology KinstonKinston, United StatesNo longer taking part
- FHCC at EvergreenHealthKirkland, United StatesTaking people
- Gundersen Lutheran Medical CenterLa Crosse, United StatesNo longer taking part
- Providence Regional Cancer System-LaceyLacey, United StatesNo longer taking part
- Good Samaritan Hospital - Cancer Centers of ColoradoLafayette, United StatesNo longer taking part
- UCI Health - Laguna HillsLaguna Hills, United StatesTaking people
- Northwestern Medicine Lake Forest HospitalLake Forest, United StatesTaking people
- Monmouth Medical Center Southern CampusLakewood, United StatesTaking people
- CommonSpirit Saint Anthony Hospital Cancer CenterLakewood, United StatesNo longer taking part
- Rocky Mountain Cancer Centers-LakewoodLakewood, United StatesNo longer taking part
- Saint Clare HospitalLakewood, United StatesNo longer taking part
- City of Hope Antelope ValleyLancaster, United StatesTaking people
- Fairfield Medical CenterLancaster, United StatesNo longer taking part
- University of Michigan Health - Sparrow LansingLansing, United StatesTaking people
- Memorial Medical Center-Las CrucesLas Cruces, United StatesTaking people
- OptumCare Cancer Care at CharlestonLas Vegas, United StatesNo longer taking part
- OptumCare Cancer Care at Fort ApacheLas Vegas, United StatesNo longer taking part
- Lawrence Memorial HospitalLawrence, United StatesTaking people
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, United StatesTaking people
- University of Kansas Cancer Center - Lee's SummitLee's Summit, United StatesTaking people
- Beebe Medical CenterLewes, United StatesNo longer taking part
- CommonSpirit Saint Joseph Medical Center - East LexingtonLexington, United StatesNo longer taking part
- Saint Joseph Radiation Oncology Resource CenterLexington, United StatesNo longer taking part
- Saint Rita's Medical CenterLima, United StatesNo longer taking part
- Cancer Partners of NebraskaLincoln, United StatesNo longer taking part
- Saint Elizabeth Regional Medical CenterLincoln, United StatesNo longer taking part
- AdventHealth LittletonLittleton, United StatesNo longer taking part
- Rocky Mountain Cancer Centers-LittletonLittleton, United StatesNo longer taking part
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, United StatesTaking people
- Hope Cancer ClinicLivonia, United StatesNo longer taking part
- CommonSpirit Saint Joseph Hospital LondonLondon, United StatesNo longer taking part
- Rocky Mountain Cancer Centers-Sky RidgeLone Tree, United StatesNo longer taking part
- Sky Ridge Medical CenterLone Tree, United StatesNo longer taking part
- City of Hope at Long Beach ElmLong Beach, United StatesTaking people
- Tibor Rubin VA Medical CenterLong Beach, United StatesNo longer taking part
- Monmouth Medical CenterLong Branch, United StatesTaking people
- Longmont United HospitalLongmont, United StatesNo longer taking part
- Rocky Mountain Cancer Centers-LongmontLongmont, United StatesNo longer taking part
- PeaceHealth Saint John Medical CenterLongview, United StatesNo longer taking part
- Kaiser Permanente Los Angeles Medical CenterLos Angeles, United StatesTaking people
- Kaiser Permanente West Los AngelesLos Angeles, United StatesTaking people
- Jewish HospitalLouisville, United StatesNo longer taking part
- Saints Mary and Elizabeth HospitalLouisville, United StatesNo longer taking part
- UofL Health Medical Center NortheastLouisville, United StatesNo longer taking part
- Banner North Colorado Medical Center - Loveland CampusLoveland, United StatesNo longer taking part
- Henry Ford Saint John Hospital - Macomb MedicalMacomb, United StatesTaking people
- Henry Ford Warren Hospital - Breast MacombMacomb, United StatesNo longer taking part
- Illinois CancerCare-MacombMacomb, United StatesNo longer taking part
- University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterMadison, United StatesTaking people
- University of Wisconsin Carbone Cancer Center - University HospitalMadison, United StatesTaking people
- OhioHealth Mansfield HospitalMansfield, United StatesNo longer taking part
- Fairview Clinics and Surgery Center Maple GroveMaple Grove, United StatesNo longer taking part
- Saint John's Hospital - HealtheastMaplewood, United StatesTaking people
- Minnesota Oncology Hematology PA-MaplewoodMaplewood, United StatesNo longer taking part
- Marietta Memorial HospitalMarietta, United StatesNo longer taking part
- OhioHealth Marion General HospitalMarion, United StatesNo longer taking part
- Saint Mary's Oncology/Hematology Associates of MarletteMarlette, United StatesNo longer taking part
- McFarland Clinic - MarshalltownMarshalltown, United StatesTaking people
- Marshfield Medical Center-MarshfieldMarshfield, United StatesTaking people
- Fremont - Rideout Cancer CenterMarysville, United StatesTaking people
- Memorial HospitalMarysville, United StatesNo longer taking part
- Carle Physician Group-Mattoon/CharlestonMattoon, United StatesTaking people
- Hillcrest Hospital Cancer CenterMayfield Heights, United StatesTaking people
- Loyola University Medical CenterMaywood, United StatesTaking people
- Aspirus Medford HospitalMedford, United StatesTaking people
- Marjorie Weinberg Cancer Center at Loyola-GottliebMelrose Park, United StatesNo longer taking part
- Baptist Memorial Hospital and Cancer Center-MemphisMemphis, United StatesTaking people
- Idaho Urologic Institute-MeridianMeridian, United StatesNo longer taking part
- Saint Luke's Cancer Institute - MeridianMeridian, United StatesNo longer taking part
- Memorial Sloan Kettering MonmouthMiddletown, United StatesTaking people
- Beebe South Coastal Health CampusMillville, United StatesTaking people
- Zablocki Veterans Administration Medical CenterMilwaukee, United StatesNo longer taking part
- Minneapolis VA Medical CenterMinneapolis, United StatesTaking people
- Abbott-Northwestern HospitalMinneapolis, United StatesNo longer taking part
- Health Partners IncMinneapolis, United StatesNo longer taking part
- Hennepin County Medical CenterMinneapolis, United StatesNo longer taking part
- Marshfield Medical Center - MinocquaMinocqua, United StatesTaking people
- Community Medical CenterMissoula, United StatesTaking people
- Saint Patrick Hospital - Community HospitalMissoula, United StatesNo longer taking part
- Ochsner LSU Health Monroe Medical CenterMonroe, United StatesNo longer taking part
- Toledo Clinic Cancer Centers-MonroeMonroe, United StatesNo longer taking part
- Monticello Cancer CenterMonticello, United StatesNo longer taking part
- Memorial Sloan Kettering BergenMontvale, United StatesTaking people
- SSM Health Good SamaritanMount Vernon, United StatesTaking people
- Knox Community HospitalMount Vernon, United StatesNo longer taking part
- Trinity Health Muskegon HospitalMuskegon, United StatesNo longer taking part
- Saint Alphonsus Cancer Care Center-NampaNampa, United StatesTaking people
- Saint Luke's Cancer Institute - NampaNampa, United StatesNo longer taking part
- Edward Hospital/Cancer CenterNaperville, United StatesTaking people
- Vanderbilt University/Ingram Cancer CenterNashville, United StatesNo longer taking part
- Baptist Memorial Hospital and Cancer Center-Union CountyNew Albany, United StatesTaking people
- Rutgers Cancer Institute of New JerseyNew Brunswick, United StatesTaking people
- UC Comprehensive Cancer Center at Silver CrossNew Lenox, United StatesTaking people
- Tulane University School of MedicineNew Orleans, United StatesNo longer taking part
- Cancer Center of Western WisconsinNew Richmond, United StatesTaking people
- New Ulm Medical CenterNew Ulm, United StatesNo longer taking part
- Memorial Sloan-Kettering Cancer CenterNew York, United StatesTaking people
- Mount Sinai HospitalNew York, United StatesNo longer taking part
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterNew York, United StatesNo longer taking part
- Helen F Graham Cancer CenterNewark, United StatesTaking people
- Medical Oncology Hematology Consultants PANewark, United StatesTaking people
- Christiana Care Health System-Christiana HospitalNewark, United StatesNo longer taking part
- Delaware Clinical and Laboratory Physicians PANewark, United StatesNo longer taking part
- Licking Memorial HospitalNewark, United StatesNo longer taking part
- Newark Radiation OncologyNewark, United StatesNo longer taking part
- Providence Newberg Medical CenterNewberg, United StatesTaking people
- City of Hope Newport BeachNewport Beach, United StatesTaking people
- Corewell Health Lakeland Hospitals - Niles HospitalNiles, United StatesTaking people
- Ballad Health Cancer Care - NortonNorton, United StatesTaking people
- Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, United StatesNo longer taking part
- Henry Ford Health Providence Novi HospitalNovi, United StatesTaking people
- Henry Ford Medical Center-ColumbusNovi, United StatesTaking people
- Cancer Care Center of O'FallonO'Fallon, United StatesTaking people
- Saint Vincent Hospital Cancer Center at Oconto FallsOconto Falls, United StatesNo longer taking part
- University of Oklahoma Health Sciences CenterOklahoma City, United StatesTaking people
- Mercy Hospital Oklahoma CityOklahoma City, United StatesNo longer taking part
- The University of Kansas Cancer Center - OlatheOlathe, United StatesTaking people
- Alegent Health Bergan Mercy Medical CenterOmaha, United StatesNo longer taking part
- Alegent Health Immanuel Medical CenterOmaha, United StatesNo longer taking part
- Alegent Health Lakeside HospitalOmaha, United StatesNo longer taking part
- Kaiser Permanente-OntarioOntario, United StatesTaking people
- Saint Alphonsus Cancer Care Center-OntarioOntario, United StatesTaking people
- UC Irvine Health- Chao Family Comprehensive Cancer CenterOrange, United StatesTaking people
- Providence Willamette Falls Medical CenterOregon City, United StatesTaking people
- University of Chicago Medicine-Orland ParkOrland Park, United StatesTaking people
- Upstate Cancer Center at OswegoOswego, United StatesTaking people
- Illinois CancerCare-Ottawa ClinicOttawa, United StatesNo longer taking part
- University of Kansas Cancer Center-Overland ParkOverland Park, United StatesTaking people
- Baptist Memorial Hospital and Cancer Center-OxfordOxford, United StatesTaking people
- Stanford Cancer Institute Palo AltoPalo Alto, United StatesNo longer taking part
- Kaiser Permanente - Panorama CityPanorama City, United StatesTaking people
- Midlands Community HospitalPapillion, United StatesNo longer taking part
- AdventHealth ParkerParker, United StatesNo longer taking part
- Illinois CancerCare-PekinPekin, United StatesNo longer taking part
- Sacred Heart HospitalPensacola, United StatesNo longer taking part
- Illinois CancerCare-PeoriaPeoria, United StatesNo longer taking part
- Methodist Medical Center of IllinoisPeoria, United StatesNo longer taking part
- Mercy Health - Perrysburg HospitalPerrysburg, United StatesNo longer taking part
- Illinois CancerCare-PeruPeru, United StatesNo longer taking part
- Valley Radiation OncologyPeru, United StatesNo longer taking part
- Jefferson Torresdale HospitalPhiladelphia, United StatesTaking people
- Thomas Jefferson University HospitalPhiladelphia, United StatesTaking people
- Cancer Center at Saint Joseph'sPhoenix, United StatesNo longer taking part
- UPMC Hillman Cancer CenterPittsburgh, United StatesNo longer taking part
- Edward Hospital/Cancer Center?PlainfieldPlainfield, United StatesTaking people
- Michigan Healthcare Professionals PontiacPontiac, United StatesTaking people
- Trinity Health IHA Medical Group-Alice Gustafson CenterPontiac, United StatesTaking people
- Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, United StatesTaking people
- Hope Cancer CenterPontiac, United StatesNo longer taking part
- Jefferson HealthcarePort Townsend, United StatesNo longer taking part
- MaineHealth Maine Medical Center - PortlandPortland, United StatesTaking people
- Providence Portland Medical CenterPortland, United StatesTaking people
- Providence Saint Vincent Medical CenterPortland, United StatesTaking people
- Southern Ohio Medical CenterPortsmouth, United StatesNo longer taking part
- Kootenai Clinic Cancer Services - Post FallsPost Falls, United StatesTaking people
- Harrison HealthPartners Hematology and Oncology-PoulsboPoulsbo, United StatesNo longer taking part
- Fairview Northland Medical CenterPrinceton, United StatesNo longer taking part
- Illinois CancerCare-PrincetonPrinceton, United StatesNo longer taking part
- Saint Mary Corwin Medical CenterPueblo, United StatesNo longer taking part
- Saint Charles Health System-RedmondRedmond, United StatesNo longer taking part
- Corewell Health Reed City HospitalReed City, United StatesTaking people
- Beebe Health CampusRehoboth Beach, United StatesTaking people
- Aspirus Cancer Care-Rhinelander-James Beck Cancer CenterRhinelander, United StatesTaking people
- Marshfield Medical Center-Rice LakeRice Lake, United StatesTaking people
- UT Southwestern Clinical Center at Richardson/PlanoRichardson, United StatesNo longer taking part
- ECU Health Oncology RichlandsRichlands, United StatesNo longer taking part
- VCU Massey Cancer Center at Stony PointRichmond, United StatesTaking people
- VCU Massey Comprehensive Cancer CenterRichmond, United StatesTaking people
- Reid HealthRichmond, United StatesNo longer taking part
- Presbyterian Rust Medical Center/Jorgensen Cancer CenterRio Rancho, United StatesTaking people
- Kaiser Permanente-RiversideRiverside, United StatesTaking people
- North Memorial Medical Health CenterRobbinsdale, United StatesNo longer taking part
- University of RochesterRochester, United StatesTaking people
- Rochester General HospitalRochester, United StatesNo longer taking part
- UW Health Carbone Cancer Center RockfordRockford, United StatesTaking people
- Mercy Cancer Center - RocklinRocklin, United StatesNo longer taking part
- Phelps Health Delbert Day Cancer InstituteRolla, United StatesTaking people
- Mercy Clinic-Rolla-Cancer and HematologyRolla, United StatesNo longer taking part
- University of California Davis Comprehensive Cancer CenterSacramento, United StatesTaking people
- Mercy Cancer Center - SacramentoSacramento, United StatesNo longer taking part
- MyMichigan Medical Center SaginawSaginaw, United StatesTaking people
- Oncology Hematology Associates of Saginaw Valley PCSaginaw, United StatesNo longer taking part
- Coborn Cancer Center at Saint Cloud HospitalSaint Cloud, United StatesTaking people
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer CenterSaint Joseph, United StatesTaking people
- Corewell Health Lakeland Hospitals - Saint Joseph HospitalSaint Joseph, United StatesNo longer taking part
- Heartland Regional Medical CenterSaint Joseph, United StatesNo longer taking part
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, United StatesTaking people
- Regions HospitalSaint Paul, United StatesNo longer taking part
- United HospitalSaint Paul, United StatesNo longer taking part
- Sainte Genevieve County Memorial HospitalSainte Genevieve, United StatesTaking people
- Salina Regional Health CenterSalina, United StatesTaking people
- Huntsman Cancer Institute/University of UtahSalt Lake City, United StatesTaking people
- Kaiser Permanente-San Diego ZionSan Diego, United StatesTaking people
- Pacific Central Coast Health Center-San Luis ObispoSan Luis Obispo, United StatesNo longer taking part
- Kaiser Permanente-San MarcosSan Marcos, United StatesTaking people
- Kootenai Clinic Cancer Services - SandpointSandpoint, United StatesTaking people
- Essentia Health SandstoneSandstone, United StatesTaking people
- Mission Hope Medical Oncology - Santa MariaSanta Maria, United StatesNo longer taking part
- MaineHealth Maine Medical Center- ScarboroughScarborough, United StatesTaking people
- TidalHealth Nanticoke / Allen Cancer CenterSeaford, United StatesNo longer taking part
- FHCC at Northwest HospitalSeattle, United StatesTaking people
- Fred Hutchinson Cancer CenterSeattle, United StatesTaking people
- Swedish Medical Center-First HillSeattle, United StatesTaking people
- University of Washington Medical Center - MontlakeSeattle, United StatesTaking people
- Pacific Gynecology SpecialistsSeattle, United StatesNo longer taking part
- Swedish Medical Center-Ballard CampusSeattle, United StatesNo longer taking part
- Swedish Medical Center-Cherry HillSeattle, United StatesNo longer taking part
- PeaceHealth United General Medical CenterSedro-Woolley, United StatesNo longer taking part
- Prisma Health Cancer Institute - SenecaSeneca, United StatesTaking people
- Saint Francis Regional Medical CenterShakopee, United StatesTaking people
- Saint Vincent Hospital Cancer Center at SheboyganSheboygan, United StatesNo longer taking part
- Henry Ford Macomb Health Center - Shelby TownshipShelby, United StatesNo longer taking part
- Providence Regional Cancer System-SheltonShelton, United StatesNo longer taking part
- Jewish Hospital Medical Center SouthShepherdsville, United StatesNo longer taking part
- Welch Cancer CenterSheridan, United StatesNo longer taking part
- LSU Health Sciences Center at ShreveportShreveport, United StatesNo longer taking part
- Ochsner LSU Health Saint Mary's Medical CenterShreveport, United StatesNo longer taking part
- Saint Joseph Medical Center Hematology and Oncology - SilverdaleSilverdale, United StatesNo longer taking part
- City of Hope South PasadenaSouth Pasadena, United StatesTaking people
- MaineHealth Cancer Care and IV Therapy - South PortlandSouth Portland, United StatesTaking people
- Henry Ford Health Providence Southfield HospitalSouthfield, United StatesTaking people
- Baptist Memorial Hospital and Cancer Center-DesotoSouthhaven, United StatesTaking people
- Southern Illinois University School of MedicineSpringfield, United StatesTaking people
- Springfield ClinicSpringfield, United StatesTaking people
- CoxHealth South HospitalSpringfield, United StatesNo longer taking part
- Mercy Hospital SpringfieldSpringfield, United StatesNo longer taking part
- Springfield Memorial HospitalSpringfield, United StatesNo longer taking part
- Springfield Regional Cancer CenterSpringfield, United StatesNo longer taking part
- Springfield Regional Medical CenterSpringfield, United StatesNo longer taking part
- Mercy Hospital Saint LouisSt Louis, United StatesTaking people
- Mercy Hospital SouthSt Louis, United StatesTaking people
- Missouri Baptist Medical CenterSt Louis, United StatesTaking people
- Mercy Infusion Center - ChippewaSt Louis, United StatesNo longer taking part
- Siteman Cancer Center at Christian HospitalSt Louis, United StatesNo longer taking part
- Siteman Cancer Center-South CountySt Louis, United StatesNo longer taking part
- Washington University School of MedicineSt Louis, United StatesNo longer taking part
- Bhadresh Nayak MD PC-Sterling HeightsSterling Heights, United StatesNo longer taking part
- Aspirus Cancer Care - Stevens PointStevens Point, United StatesTaking people
- Marshfield Medical Center-River Region at Stevens PointStevens Point, United StatesTaking people
- Lakeview HospitalStillwater, United StatesNo longer taking part
- Tufts Medical Center Cancer Center StonehamStoneham, United StatesTaking people
- Missouri Baptist Sullivan HospitalSullivan, United StatesTaking people
- ProMedica Flower HospitalSylvania, United StatesTaking people
- State University of New York Upstate Medical UniversitySyracuse, United StatesTaking people
- SUNY Upstate Medical Center-Community CampusSyracuse, United StatesTaking people
- Franciscan Research Center-Northwest Medical PlazaTacoma, United StatesNo longer taking part
- Northwest Medical Specialties PLLCTacoma, United StatesNo longer taking part
- MyMichigan Medical Center TawasTawas City, United StatesTaking people
- National Jewish Health-Northern Hematology OncologyThornton, United StatesNo longer taking part
- Rocky Mountain Cancer Centers-ThorntonThornton, United StatesNo longer taking part
- Mercy Health - Saint Anne HospitalToledo, United StatesNo longer taking part
- Mercy Health - Saint Vincent HospitalToledo, United StatesNo longer taking part
- Toledo Clinic Cancer Centers-ToledoToledo, United StatesNo longer taking part
- Community Medical CenterToms River, United StatesTaking people
- University of Kansas Health System Saint Francis CampusTopeka, United StatesTaking people
- City of Hope South BayTorrance, United StatesTaking people
- Munson Medical CenterTraverse City, United StatesTaking people
- Dayton Physicians LLC - TroyTroy, United StatesNo longer taking part
- Upper Valley Medical CenterTroy, United StatesNo longer taking part
- Banner University Medical Center - TucsonTucson, United StatesTaking people
- University of Arizona Cancer Center-North CampusTucson, United StatesTaking people
- Saint Luke's Cancer Institute - Twin FallsTwin Falls, United StatesNo longer taking part
- Memorial Sloan Kettering NassauUniondale, United StatesTaking people
- City of Hope UplandUpland, United StatesTaking people
- Carle Cancer CenterUrbana, United StatesTaking people
- The Carle Foundation HospitalUrbana, United StatesNo longer taking part
- PeaceHealth Southwest Medical CenterVancouver, United StatesNo longer taking part
- Upstate Cancer Center at VeronaVerona, United StatesTaking people
- Essentia Health Virginia ClinicVirginia, United StatesTaking people
- MD Anderson Cancer Center at Cooper-VoorheesVoorhees Township, United StatesTaking people
- Ridgeview Medical CenterWaconia, United StatesTaking people
- Providence Saint Mary Regional Cancer CenterWalla Walla, United StatesNo longer taking part
- Henry Ford Health Warren HospitalWarren, United StatesTaking people
- Henry Ford Warren Hospital - GLCMSWarren, United StatesTaking people
- Advanced Breast Care Center PLLCWarren, United StatesNo longer taking part
- Henry Ford Madison Heights Hospital - BreastWarren, United StatesNo longer taking part
- Macomb Hematology Oncology PCWarren, United StatesNo longer taking part
- Saint Joseph Warren HospitalWarren, United StatesNo longer taking part
- Northwestern Medicine Cancer Center WarrenvilleWarrenville, United StatesTaking people
- Illinois CancerCare - WashingtonWashington, United StatesNo longer taking part
- Mercy Hospital WashingtonWashington, United StatesNo longer taking part
- Sibley Memorial HospitalWashington D.C., United StatesTaking people
- MedStar Georgetown University HospitalWashington D.C., United StatesNo longer taking part
- UI Health Care Mission Cancer and Blood - Waukee ClinicWaukee, United StatesTaking people
- Aspirus Cancer Care-WausauWausau, United StatesTaking people
- Wilmot Cancer Institute at WebsterWebster, United StatesTaking people
- Henry Ford West Bloomfield HospitalWest Bloomfield, United StatesTaking people
- Saint Mary's Oncology/Hematology Associates of West BranchWest Branch, United StatesNo longer taking part
- University of Cincinnati Cancer Center-West ChesterWest Chester, United StatesNo longer taking part
- Mercy Medical Center-West LakesWest Des Moines, United StatesNo longer taking part
- Methodist West HospitalWest Des Moines, United StatesNo longer taking part
- Saint Ann's HospitalWesterville, United StatesNo longer taking part
- Marshfield Medical Center - WestonWeston, United StatesTaking people
- University of Kansas Hospital-Westwood Cancer CenterWestwood, United StatesTaking people
- Geisinger Wyoming Valley/Henry Cancer CenterWilkes-Barre, United StatesTaking people
- Rice Memorial HospitalWillmar, United StatesNo longer taking part
- Asplundh Cancer PavilionWillow Grove, United StatesTaking people
- Christiana Care Health System-Wilmington HospitalWilmington, United StatesNo longer taking part
- Aspirus Cancer Care - Wisconsin RapidsWisconsin Rapids, United StatesTaking people
- Fairview Cancer Center - WoodburyWoodbury, United StatesTaking people
- Minnesota Oncology Hematology PA-WoodburyWoodbury, United StatesNo longer taking part
- Woodland Memorial HospitalWoodland, United StatesNo longer taking part
- Kaiser Permanente-Woodland HillsWoodland Hills, United StatesTaking people
- Wright-Patterson Medical CenterWright-Patterson Air Force Base, United StatesNo longer taking part
- Henry Ford Wyandotte HospitalWyandotte, United StatesTaking people
- University of Michigan Health - WestWyoming, United StatesTaking people
- Fairview Lakes Medical CenterWyoming, United StatesNo longer taking part
- North Star Lodge Cancer Center at Yakima Valley Memorial HospitalYakima, United StatesTaking people
- Providence Regional Cancer System-YelmYelm, United StatesNo longer taking part
- Rush-Copley Healthcare CenterYorkville, United StatesNo longer taking part
- Saint Elizabeth Youngstown HospitalYoungstown, United StatesNo longer taking part
- Huron Gastroenterology PCYpsilanti, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, United StatesTaking people
- Genesis Healthcare System Cancer Care CenterZanesville, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Cancer Institute (NCI)
- Trial code
- NCT04269902
- Record updated
- 5 November 2026
- Original description
This phase III trial compares early treatment with venetoclax and obinutuzumab versus delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Immunotherapy with monoclonal antibodies, such as obinutuzumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Starting treatment with the venetoclax and obinutuzumab early (before patients have symptoms) may have better outcomes for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma compared to starting treatment with the venetoclax and obinutuzumab after patients show symptoms.Read full original descriptionShow less
Randomized, Phase III Study of Early Intervention With Venetoclax and Obinutuzumab Versus Delayed Therapy With Venetoclax and Obinutuzumab in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): EVOLVE CLL/SLL Study
This phase III trial compares early treatment with venetoclax and obinutuzumab versus delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Immunotherapy with monoclonal antibodies, such as obinutuzumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Starting treatment with the venetoclax and obinutuzumab early (before patients have symptoms) may have better outcomes for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma compared to starting treatment with the venetoclax and obinutuzumab after patients show symptoms.
Inclusion: Participants must have a confirmed diagnosis of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) (collectively referred to as CLL throughout) according to the 2018 International Workshop on CLL. Participants must have been diagnosed within 18 months prior to registration; Participants must have CLL-International Prognostic Index (CLL-IPI) score >= 4 and/or complex cytogenetics (defined as 3+ chromosomal abnormalities); Cytogenetic AND/OR FISH analyses must be completed at a Clinical Laboratory Improvement Act (CLIA)-approved (or laboratories accredited under Accreditation Canada Diagnostics to conduct FISH analyses) laboratory within 18 months prior to registration. At minimum, FISH panel should use probes to detect for abnormalities in chromosomes 13q, 12, 11q, and 17p; TP53 gene mutation analysis performed at any CLIA-approved (or laboratories accredited under Accreditation Canada Diagnostics) lab (if completed) must be obtained within 18 months prior to registration. This sequencing test is distinct from FISH studies for del(17p); Note: TP53 gene mutation analysis is recommended but not required if the participant meets disease-related study criteria via a combination of risk factors that totals a score of 4 on the CLL-IPI score and/or has complex cytogenetics completed; Immunoglobulin heavy chain locus variable (IgVH) gene mutation analysis performed at any CLIA-approved lab (or laboratories accredited under Accreditation Canada Diagnostics) must be obtained prior to registration (at any time prior to registration); Serum beta-2 microglobulin level must be obtained within 28 days prior to registration; Participants must not meet any of the IWCLL specified criteria for active CLL therapy; Treatment with high dose corticosteroids and/or intravenous immunoglobulin for autoimmune complications of CLL must be complete at least 4 weeks prior to enrollment; Steroids used for treatment of conditions other than CLL/SLL must be at a dose of at most 20 mg/day of prednisone or equivalent corticosteroid at the time of registration; Prior therapy with anti CD20 monoclonal antibodies is not allowed; Participants must not have received or be currently receiving any prior CLL-directed therapy, including non-protocol-related therapy, anti-cancer immunotherapy, experimental therapy (with exception of agents approved for emergency access use for the prevention or treatment of coronavirus disease 2019 [COVID-19]), or radiotherapy; Participants must not be receiving or planning to receive any other investigational agents before completing protocol therapy; Participants must be >= 18 years of age; Participants must have Eastern Cooperative Oncology Group (ECOG) performance status =< 2; Platelet count >= 100,000/mm\^3 within 28 days prior to registration; Absolute neutrophil count (ANC) >= 1,000/mm\^3 within 28 days prior to registration; Creatinine clearance >= 30mL/min (by Cockcroft Gault) within 28 days prior to registration; Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3.0 x upper limit of normal (ULN) within 28 days prior to registration; Total bilirubin =< 2.0 x ULN (or 5.0 x ULN if the participant has a history of Gilbert's disease), within 28 days prior to registration; Participants must be able to take oral medications; Human immunodeficiency virus (HIV)-infected participants on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial; Participants with history of malignancy are allowed providing the cancer has not required active treatment within 2 years prior to registration (hormonal therapy is permissible). The following exceptions are permissible: basal cell, squamous cell skin, or non-melanomatous skin cancer, in situ cervical cancer, superficial bladder cancer not treated with intravesical chemotherapy or Bacillus Calmette-Guerin (BCG) within 6 months, localized prostate cancer treated with surgical resection and/or radiation only or requiring no more than chronic hormonal therapy, or prostate cancer with Gleason score ≤ 6, or localized breast cancer treated with surgical resection and/or radiation only or requiring no more than chronic hormonal therapy; Participants must not have current, clinically significant gastrointestinal malabsorption, in the opinion of treating doctor; Participants must not have cirrhosis; Obinutuzumab has been associated with hepatitis reactivation. Participants must not have uncontrolled active infection with hepatitis B or C. Participants with latent hepatitis B infection must agree to take prophylaxis during and for 6 months following active protocol therapy with V-O; Active infection with hepatitis B or C:; Active infection is defined as detectable hepatitis B deoxyribonucleic acid (DNA) or hepatitis C ribonucleic acid (RNA) by quantitative polymerase chain reaction (PCR); Latent infection with hepatitis B:; Latent infection is defined as meeting all of the following criteria:; Hepatitis B surface antigen positive; Anti-hepatitis B total core antibody positive; Anti-hepatitis IgM core antibody undetectable; Hepatitis B PCR undetectable; Participants with latent hepatitis B infection must agree to take prophylaxis with anti-hepatitis agents during and for 6 months following active protocol therapy with V-O; Participants who have received intravenous immunoglobulin (IVIG) therapy within 6 months who are hepatitis B core total antibody positive but PCR undetectable are not mandated to take prophylaxis; Participants must not have had major surgery within 30 days prior registration or minor surgery within 7 days prior to registration. Examples of major surgery include neurosurgical procedures, joint replacements, and surgeries that occur inside the thoracic or abdomino-pelvic cavities. Examples of minor surgery include dental surgery, insertion of a venous access device, skin biopsy, or aspiration of a joint. If a participant has had a bone marrow biopsy for diagnosis or evaluation of CLL, this will not exclude the participant from registration to the study. If there is a question about whether a surgery is major or minor, this should be discussed with the Study Chair; Participants must not have known bleeding disorders (e.g., von Willebrand's disease or hemophilia); Participants must not have a history of stroke or intracranial hemorrhage within 6 months prior to enrollment; Participants must not require continued therapy with a strong inhibitor or inducer of CYP3A4/5, as venetoclax is extensively metabolized by CYP3A4/5; Participants must not have uncontrolled autoimmune hemolytic anemia or idiopathic thrombocytopenia purpura; Participants must not have any currently active, clinically significant cardiovascular disease, such as uncontrolled arrhythmia or class 3 or 4 congestive heart failure as defined by the New York Heart Association Functional Classification; Participants must not have a history of myocardial infarction, unstable angina, or acute coronary syndrome within 6 months prior to enrollment; Participants must not be pregnant or nursing, as there are no safety data available for these drug regimens during pregnancy. Women/men of reproductive potential must have agreed to use an effective contraceptive method. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate participant chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures; Participants must agree to have specimens submitted for translational medicine (MRD) as outlined; Participants must be offered the opportunity to participate in specimen banking for future research as outlined; NOTE: With participant's consent, the site must follow through with specimen submission as outlined; Participants who are able to complete patient reported outcome (PRO) forms in English, Spanish, French, German, Russian or Mandarin must be offered the opportunity to participate in the quality of life assessments. (Those participants who are unable to read and write in English, Spanish, French, German, Russian or Mandarin may be registered to S1925 without contributing to the quality of life portion of the study.); Participants must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines; NOTE: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system.