Pathogenic Study of Adult Immune Enteropathies
Key facts
- Who runs it
- Institut National de la Santé Et de la Recherche Médicale, France
- Where
- France4 sites in 1 countryChoose a country to see its sites
- Trial code
- Status
- Recruiting
- People taking part
- 200 people, planned
- Started
- 27 Feb 2020
- Expected to end
- 27 Feb 2033
- Type of study
- Observational, 7 groups
- Treatments tested
- Blood sample collection; gastrointestinal biopsy
- Record updated
- 27 October 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- 18 years or over
- affiliated to social insurance
- signed informed consent
Who cannot take part
- pregnancy
- under guardianship
- not able to sign informed consent
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced intestinal diseases. Mechanisms of transformation of lymphocytes leading to onset of lymphomatous complications of immune enteropathies will be investigated. Mechanisms of loss of hepatic lymphocytic homeostasis will also be assessed in liver associated diseases.
The 7 groups in the trial
- Active coeliac patients
Patients with active coeliac disease
Treatment: Blood sample collection; gastrointestinal biopsy
- Treated coeliac patients
Patients with coeliac disease on gluten free diet
Treatment: Blood sample collection; gastrointestinal biopsy
- Sprue type I
Patients with refractory coeliac disease of type I
Treatment: Blood sample collection; gastrointestinal biopsy
- Sprue type II
Patients with refractory coeliac disease of type II
Treatment: Blood sample collection; gastrointestinal biopsy
- Intestinal Lymphoproliferations
Patients with intestinal lymphoproliferations
Treatment: Blood sample collection; gastrointestinal biopsy
- Non coeliac enteropathies
Patients with non coeliac immune-mediated enteropathy
Treatment: Blood sample collection; gastrointestinal biopsy
- Patients without neoplastic or inflammatory intestinal disease
Treatment: Blood sample collection; gastrointestinal biopsy
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 27 October 2026