Exercise, Creatine and Coenzyme Q10 for Childhood Myositis
Key facts
- Who runs it
- The Hospital for Sick Children
- Where
- Canada1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 15 people enrolled
- Started
- 6 Apr 2021
- Ended
- 5 Mar 2024
- Type of study
- Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
- Treatments tested
- creatine monohydrate
- ubiquinol
- glucose tablet
- gel capsule
- Exercise
- Record updated
- 28 April 2026
Who can take part
- Age
- 7 years to 18 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Ages 7 to 18 years
- Diagnosis of juvenile idiopathic inflammatory myopathy (JIIM) according to the 2017 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) criteria: ≥90% probability, age of onset <18 years
- Subjects on a stable course of medication (unlikely to change over study treatment period as determined by treating physician)
- Minimum height of 132.5cm (required to fit on the cycle ergometer)
Who cannot take part
- Subjects with newly diagnosed JIIM within the previous 6 months
- Subjects currently taking anti-hypertensive drugs or blood thinners
- Subjects with impaired kidney function as determined from pre-baseline visit screening lab values (eGFR <90 ml/min/1.73m\^2)
- Subjects unable to cooperate with study procedures, or too weak to participate in the exercise testing
- Subjects who are currently pregnant or planning to become pregnant within the study period
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Children with Juvenile Idiopathic Inflammatory Myopathies (JIIM) are weak and get tired because their muscles aren't able to work like healthy muscles. This can make it hard for them to do normal everyday things and can make them less happy about their lives compared to children without the disease. There are two nutritional supplements that help muscles use energy and recover after exercise: creatine and coenzyme Q10. If the muscle has more energy, it may not be as weak and may not feel as tired or sore after exercise. Because of this we want to see if having children with JIIM take creatine and coenzyme Q10 can make them stronger and less tired. If this works, we hope it will let them be able to do the things that healthy children can do, and make them feel better about their lives.
The 2 groups in the trial
- TreatmentTreatment being tested
patients in this arm will be treated with creatine and coenzyme Q10 supplements
Treatment: creatine monohydrate, ubiquinol, and Exercise
- PlaceboPlacebo, for comparison
patients in this arm will be given placebo supplements that look and taste identical to the active supplements
Treatment: glucose tablet, gel capsule, and Exercise
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Effects of Exercise, Creatine, and Coenzyme Q10 Supplementation on Muscle Function in Children With Myositis
- Publications
- Creatine and CoQ10 with physical activity on muscle function in children with myositis: a proof-of-concept trial.Rheumatology (Oxford, England), 2026
- Record updated
- 28 April 2026