Brain Stimulation During Arm Reaching in People Recovering From Stroke
Tests magnetic brain stimulation during robot-guided arm reaching in adults with stroke.
Plain-language title generated from the registry record
Registry title: Brain Connections for Arm Movement After Stroke
Key facts
- Where
- Pittsburgh, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 45 and 90 years old?
Source: NCT04286516, who can take part
Where in United States
- VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PAPittsburgh, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- VA Office of Research and Development
- Trial code
- NCT04286516
- Record updated
- 2 June 2026
- Original description
The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to discover how different brain areas control movement before and after stroke and when these brain areas are most sensitive to TMS.Read full original descriptionShow less
Brain Areas That Control Reaching Movements After Stroke: Task-relevant Connectivity and Movement-synchronized Brain Stimulation
The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to discover how different brain areas control movement before and after stroke and when these brain areas are most sensitive to TMS.
Inclusion: Be 45-90 years of age; Have adequate language and neurocognitive function to participate in training and testing; Be medically stable to participate in the study; Be English speaking; Be 45-90 years of age; Clinically defined, unilateral, hemiparetic stroke with radiologic exclusion of other possible diagnosis; Stroke onset at least 6 months before enrollment; Subcortical stroke (ex: internal capsule, deep white matter of posterior frontal lobe); Present with mild to moderate arm dysfunction; Be medically stable to participate in the study; Be English speaking.
Exclusion: Have a serious complicating medical illness that would preclude participation; Presence of medical condition or implant that prevents safe administration of TMS or MRI; (for both groups); Unable to give informed consent; Contractures or orthopedic problems limiting range of joint motion in the potential study arm or other impairments that would interfere with the study activities; Visual loss such that the subject would not be able to see the test patterns on the robot computer monitor; Unable to comply with requirements of the study; Enrollment in another greater-than-minimal risk study; Pregnancy.