NCT04290988Terminated
Circuitry Assessment and Reinforcement Training Effects on Recovery
Circuitry Assessment and Reinforcement Training Effects on Recovery (CARTER)
Source: ClinicalTrials.gov · Last updated 5 Feb 2026
Brief summary (registry, in English)
This study investigates if electroencephalography (EEG) neurofeedback training is more beneficial than sham feedback training for the improvement of communication, anxiety, and sleep quality in individuals with aphasia. Half of the participants will receive active EEG neurofeedback sessions first, followed by sham feedback sessions in a crossover design. The other half of participants will undergo sham feedback sessions first, followed by active neurofeedback.
- Status (registry)
- Terminated
- Study type
- Interventional
- Enrollment
- 7 (actual)
- First submitted
- 27 Feb 2020
- Start date
- 23 Sept 2020
- Primary completion date
- 1 Sept 2025
- Lead sponsor
- Johns Hopkins University
- Diseases
- Frontotemporal dementia, Stroke
- NCT number
- NCT04290988
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior history of neurologic disease affecting the brain (e.g., brain tumor, multiple sclerosis, traumatic brain injury) other than stroke or PPA and its underlying neurological pathologies: Alzheimer's Disease, Frontotemporal Lobar Degeneration or Dementia with Lewy bodies
- Prior history of severe psychiatric illness, developmental disorders or intellectual disability (e.g., PTSD, major depression, bipolar disorder, schizophrenia, obsessive compulsive disorder (OCD), autism spectrum disorders)
Other
- Lack of English proficiency
- Not medically stable
- Picture naming accuracy above 80% on the Philadelphia Naming Test (PNT)
- Uncorrected severe visual loss or hearing loss by self-report and medical records
Who the study is looking for
- Diagnosis of PPA or aphasia secondary to stroke and presence of naming deficits with confirmation of diagnosis by neurologist
- Capable of giving informed consent or indicating another to provide informed consent
- Age 18 or older.
- If aphasia is secondary to stroke, the stroke must have occurred between 6 months and 5 years prior to enrollment in the study.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins School of Medicine | Baltimore | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.