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Taking people in United StatesPhase 2

Optimal Dosing For Low-Dose Aspirin Chemoprophylaxis For VTE Following Total Joint Arthroplasty

Key facts

Who runs it
University of Miami
Where
Miami, United StatesSee the site
Trial code
Status
Recruiting
Phase
Phase 2
People taking part
5,478 people, planned
Started
1 Mar 2021
Expected to end
1 Mar 2027
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • Aspirin
Record updated
11 March 2026

Who can take part

Age
19 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 10 criteriaShow less

Who can take part

  • > 18 years of age
  • Planning to undergo a primary total hip or knee arthroplasty

Who cannot take part

  • High risk patients for VTE as defined by:; History of venous thromboembolism; Active malignancy; Known pro thrombotic condition
  • Patients requiring anticoagulation for pre-existing conditions
  • Patients with the contraindication for use of aspirin or nonsteroidal antiinflammatory drugs for reasons such as peptic ulcer disease, intolerance, others
  • Reported to have mental illness or belonging to a vulnerable population
  • BMI > 40
  • Patients not fluent in the language of the informed consent form
  • Prisoners
  • Pregnancy

Where in United States

  • University of Miami HospitalMiami, United StatesContact: Ramakanth YakkantiTaking people

About the trial

What the trial wants to find out

This research study is attempting to answer the question of whether 81 mg aspirin once daily is as effective as 81 mg aspirin twice daily in preventing blood clots after total joint replacement surgery.

The 2 groups in the trial

  • Treatment Once DailyTreatment being tested

    Participant receives 81 mg aspirin taken once daily beginning the night before surgery and up to 28 days post surgery.

    Treatment: Aspirin

  • Treatment Twice DailyExisting treatment, for comparison

    Participant receives 81 mg aspirin taken twice daily (one in the morning and one at night) beginning at the night before surgery and up to 28 days post surgery.

    Treatment: Aspirin

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Optimal Dosing For Low-Dose Aspirin Chemoprophylaxis For Venous Thromboembolism (VTE) Following Total Joint Arthroplasty - A Multi-center Prospective Randomized Control Trial.
Record updated
11 March 2026
Optimal Dosing For Low-Dose Aspirin Chemoprophylaxis For VTE Following Total Joint Arthroplasty (NCT04295486) – Frontlight Research