Intelligent Spine Interface, Clinical (ISI-C)

Who can take part

• • Adults (men or women) between the ages of 18 and 65 years old; Complete or Incomplete SCI with AIS grade of A or B between the levels of C7/T1 and T10 (level and degree of injury based on the international standards for neurological classification of SCI (ISNCSCI)); Focal area of SCI due to trauma; SCI date of injury > 1 year prior to enrollment; Completed prior SCI rehabilitation program; Ability to use both upper extremities to ambulate with a wheelchair or crutches; Distance between the conus medullaris and site of injury must be > 4 cm; The ability to participate in intensive physical therapy and research > 4 hours per day for 2 weeks; Must provide informed consent prior to study participation

Who cannot take part

• • Presence of co-existing lower extremity neuropathy or disorders of the cauda equina; Presence of non-traumatic spinal cord pathology; Significant cognitive impairment or decreased level of consciousness; Presence of an intrathecal baclofen or morphine pump; Presence of a cardiac defibrillator or pacemaker; Presence of a deep brain stimulator device; Patient who has any contraindication to having a MRI performed; Severe or disabling joint contractures in the lower extremities; Presence of hematologic disorder or medication related coagulopathy that would preclude surgery; Lower extremity congenital or acquired deformities; Women who are pregnant or who are unwilling to use contraception during the study period; Body mass index > 30; Cardiopulmonary comorbidities that preclude participation in intensive physical therapy; Known or suspected patient non-compliance during the study period and at follow up; Patient life expectancy < 12 months; Presence of patient comorbidities or spinal anatomy that would preclude participation in the study per investigators' recommendation