The DURATION Study: reDUcing sedentaRy behAviour to Maintain cogniTIve functiON.
Reason given: Principal investigator moved to a different role
Key facts
- Where
- London, CanadaSee the site
Where in Canada
- The University of Western OntarioLondon, CanadaNo longer taking part
Trial details
- Who runs it
- Western University, Canada
- Trial code
- NCT04323423
- Record updated
- 5 March 2024
- Original description
Rationale: Older adults spend the majority of their time in sedentary behaviours (SB). High amounts of SB have been correlated with reduced cognitive performance. Long periods of time spent sitting results in excessive glycemic variability, potentially contributing to cognitive decline. Reducing/replacing SB with short intermittent bouts of light physical activity have shown positive effects on glycemic variability. Thus, interrupting prolonged sitting with bouts of light physical activity may regulate blood glucose and thus mitigate cognitive decline.Read full original descriptionShow less
Determining the Optimal Reduction in Sedentary Behaviour to Reduce Glycemic Variability and Maintain Cognition: a Randomized Control Trial
Rationale: Older adults spend the majority of their time in sedentary behaviours (SB). High amounts of SB have been correlated with reduced cognitive performance. Long periods of time spent sitting results in excessive glycemic variability, potentially contributing to cognitive decline. Reducing/replacing SB with short intermittent bouts of light physical activity have shown positive effects on glycemic variability. Thus, interrupting prolonged sitting with bouts of light physical activity may regulate blood glucose and thus mitigate cognitive decline.
Purpose: This study intends to investigate the appropriate interval frequency of post-prandial SB reduction, by light physical activity needed to optimize total and incremental area under the curve for glucose response in overweight older adults at risk for glucose intolerance with mild cognitive impairment in both lab and free-living environments. Second, this study aims to investigate the acute impact of reducing SB on glycemic variability and its relationship with cognition.
Hypothesis: First, there will be a dose-dependent response of more frequent interruptions of SB (more frequent intervals of light physical activity) with better glycemic control. Second, reducing SB will result in less glycemic variability, which will translate into better levels of cognitive performance.
Methods: Generalized linear mixed models with random intercepts will be used to evaluate the differential effects of the experimental conditions on the selected outcomes.
Inclusion: Age ≥ 65 years; Have a caregiver that works with you at least 20 hours a week (needs to be present for the familiarization session (explained below) and drop-off and pick-up from lab sessions); Diagnosis of diabetes by a healthcare provider (e.g. family doctor); Diagnosis of MCI by a healthcare provider; Self-report being physically inactive (not meeting the current PA guidelines of 150 min MVPA/week); Self-report being sedentary- (defined as self-reported sedentary time ≥ 7 h/day); Able to walk one block without an assistive device; Own a smartphone with unlimited outgoing text messages and access to internet connection. The smartphone must be either iphone 7 (with iOS of 12.2 or higher) or Android operating system 5 or higher to allow for Libre View mobile application compatibility; Able to read, write and understand English.
Exclusion: Medication: hypoglycemics; antilipidemics; antidepressants; beta blockers; anti-anxiety agents; Excessive alcohol consumption (> 8 points on the Alcohol Use Disorders Identification Test); Uncontrolled hypertension (measured systolic > 140 mmHg or diastolic > 90 mmHg); Currently smoke; Depression (Geriatric Depression Score short-form > 6 (GDS)) (Yesavage, Brink, Rose, \& et al, 1983); Peri-menopausal or menopausal women (must be post-menopausal).