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Taking people in United StatesPhase 2

UCSD Image-Guided Cognitive-Sparing Radiosurgery for Intracranial Lesions

Key facts

Who runs it
Jona Hattangadi-Gluth
Where
San Diego, United StatesSee the site
Trial code
Status
Recruiting
Phase
Phase 2
People taking part
90 people, planned
Started
1 May 2019
Expected to end
31 Dec 2028
Type of study
Interventional
Treatments tested
  • Cognitive Sparing Brain Stereotactic Radiosurgery (SRS)
Record updated
8 September 2026

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 16 criteriaShow less

Who can take part

  • Patients 18 years or older
  • Eligible for intracranial SRS: Limited brain metastases targets geometrically feasible for SRS (intact or resected tumor bed), meningioma, or cerebral AVM
  • Eastern cooperative Oncology Group (ECOG) performance status 0-2 (score of 0, no symptoms; 1, mild symptoms; 2, symptomatic, <50% in bed during the day)
  • Ability to answer questions and follow commands via neurocognitive testing
  • Estimated life expectancy greater than 6 months
  • Pathologic confirmation of extracerebral tumor site (eg, lung, breast, prostate) from either the primary site or a metastatic lesion if brain metastasis
  • Willingness/Ability to undergo brain MRI scans
  • Able to give informed consent

Who cannot take part

  • Planned chemotherapy during SRS (on the day of SRS)
  • Previous whole brain radiation therapy
  • Pregnant or nursing women
  • Women of childbearing potential unwilling to use adequate contraception
  • Inability to complete a magnetic resonance imaging scan with contrast
  • Tumor directly invading the critical area to be spared (for example a patient with tumor invading a critical white matter tract; ineligible for cognitive-sparing)
  • Leptomeningeal metastases (ineligible for SRS)
  • Metastases from primary germ cell tumor, small cell carcinoma, or primary CNS lymphoma (ineligible for SRS)

Where in United States

  • Moores Cancer CenterSan Diego, United StatesContact: Sheila MedinaTaking people

About the trial

What the trial wants to find out

In this proposal, the investigators introduce advanced diffusion and volumetric imaging techniques along with innovative, automated image parcellation methods to identify critical brain regions, incorporate into cognitive-sparing SRS for intracranial lesions, and analyze biomarkers of radiation response. This work will advance the investigators' understanding of neurocognitive changes after brain SRS and help create interventions that preserve cognitive-function in patients with intracranial lesions.

The group in the trial

  • Image-guided cognitive sparing brain SRSTreatment being tested

    This is a single arm phase II study where enrolled subjects will receive intracranial SRS will performed identically to standard of care, except for implementing additional imaging techniques and software for additional regional avoidance for cognitive sparing (specifically sparing white matter and the bilateral hippocampus)

    Treatment: Cognitive Sparing Brain Stereotactic Radiosurgery (SRS)

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
UCSD Image-Guided Cognitive-Sparing Radiosurgery for Intracranial Lesions: Avoidance of Eloquent White Matter and Hippocampal Regions
Record updated
8 September 2026